ENSMUSG00000056055


Mus musculus

Features
Gene ID: ENSMUSG00000056055
  
Biological name :Sag
  
Synonyms : P20443 / Sag / S-antigen, retina and pineal gland (arrestin)
  
Possible biological names infered from orthology : P10523 / S-antigen visual arrestin
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: D
Gene start: 87803680
Gene end: 87845158
  
Corresponding Affymetrix probe sets: 10348301 (MoGene1.0st)   1419025_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000076948
Ensembl peptide - ENSMUSP00000136729
NCBI entrez gene - 20215     See in Manteia.
MGI - MGI:98227
RefSeq - XM_017319397
RefSeq - NM_009118
RefSeq - XM_006529274
RefSeq - XM_011247944
RefSeq - XM_017319395
RefSeq - XM_017319396
RefSeq Peptide - NP_033144
swissprot - P20443
swissprot - Q3UPX6
swissprot - J3QNF6
Ensembl - ENSMUSG00000056055
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sagaENSDARG00000012610Danio rerio
 sagbENSDARG00000038378Danio rerio
 SAGENSGALG00000001696Gallus gallus
 SAGENSG00000130561Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Arrb1 / Q8BWG8 / Beta-arrestin-1 / P49407* / arrestin beta 1*ENSMUSG0000001890956
Arrb2 / Q91YI4 / Beta-arrestin-2 / P32121* / arrestin beta 2*ENSMUSG0000006021652
Arr3 / Q9EQP6 / Arrestin-C / P36575* / arrestin 3*ENSMUSG0000006089048


Protein motifs (from Interpro)
Interpro ID Name
 IPR000698  Arrestin
 IPR011021  Arrestin-like, N-terminal
 IPR011022  Arrestin C-terminal-like domain
 IPR014753  Arrestin, N-terminal
 IPR014756  Immunoglobulin E-set
 IPR017864  Arrestin, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 cellular_componentGO:0001750 photoreceptor outer segment ISS
 cellular_componentGO:0001917 photoreceptor inner segment IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0002046 opsin binding IDA
 molecular_functionGO:0030507 spectrin binding ISO
 molecular_functionGO:0051219 phosphoprotein binding IDA


Pathways (from Reactome)
Pathway description
Inactivation, recovery and regulation of the phototransduction cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000195 hypocalcemia "subnormal concentrations of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ush1ctm1a(KOMP)Wtsi/Ush1ctm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Ush1ctm1a(KOMP)Wtsi/Wtsi

 MP:0004021 abnormal rod electrophysiology "anomaly in the function of dark adapted vision mediated by the rods" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Neurod2tm1Tap/Neurod2+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Sagtm1Jnc/Sagtm1Jnc,Rhotm1Shda/Rhotm1Shda
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0004022 abnormal cone electrophysiology "anomaly in the function of light adapted vision mediated by the cones" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gjd2tm1Paul/Gjd2tm1Paul
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008456 abnormal retinal rod cell outer segment morphology "any strucutral anomaly of the retinal rod cell region which contains stacks of membranous discs separate from the outer cell membrane that are rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Neurod2tm1Tap/Neurod2+
Genetic Background: involves: 129/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000030324 Rho / P15409 / Rhodopsin / P08100*  / complex






 

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