ENSG00000180914


Homo sapiens

Features
Gene ID: ENSG00000180914
  
Biological name :OXTR
  
Synonyms : OXTR / oxytocin receptor / P30559
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: p25.3
Gene start: 8750408
Gene end: 8769628
  
Corresponding Affymetrix probe sets: 206825_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000324270
Ensembl peptide - ENSP00000414828
Ensembl peptide - ENSP00000389587
NCBI entrez gene - 5021     See in Manteia.
OMIM - 167055
RefSeq - XM_011533762
RefSeq - NM_000916
RefSeq - NM_001354653
RefSeq - NM_001354654
RefSeq - NM_001354655
RefSeq - NM_001354656
RefSeq Peptide - NP_001341582
RefSeq Peptide - NP_001341583
RefSeq Peptide - NP_001341584
RefSeq Peptide - NP_001341585
RefSeq Peptide - NP_000907
swissprot - C9JQC4
swissprot - B2R9L7
swissprot - P30559
swissprot - C9JN09
Ensembl - ENSG00000180914
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 oxtrENSDARG00000033956Danio rerio
 oxtrlENSDARG00000044175Danio rerio
 OXTRENSGALG00000003138Gallus gallus
 OxtrENSMUSG00000049112Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AVPR1B / P47901 / arginine vasopressin receptor 1BENSG0000019804951
AVPR1A / P37288 / arginine vasopressin receptor 1AENSG0000016614848
AVPR2 / P30518 / arginine vasopressin receptor 2ENSG0000012689537
NPSR1 / Q6W5P4 / neuropeptide S receptor 1ENSG0000018725825
GNRHR / P30968 / gonadotropin releasing hormone receptorENSG0000010916321
GPR19 / Q15760 / G protein-coupled receptor 19ENSG0000018315020


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR001817  Vasopressin receptor
 IPR002062  Oxytocin receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001967 suckling behavior IEA
 biological_processGO:0001975 response to amphetamine IEA
 biological_processGO:0001992 regulation of systemic arterial blood pressure by vasopressin IBA
 biological_processGO:0006936 muscle contraction TAS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway TAS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0007565 female pregnancy IBA
 biological_processGO:0007595 lactation TAS
 biological_processGO:0007613 memory IEA
 biological_processGO:0010701 positive regulation of norepinephrine secretion IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0021537 telencephalon development IEA
 biological_processGO:0030431 sleep IEA
 biological_processGO:0032230 positive regulation of synaptic transmission, GABAergic IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0032570 response to progesterone IEA
 biological_processGO:0032870 cellular response to hormone stimulus IBA
 biological_processGO:0034059 response to anoxia IEA
 biological_processGO:0034097 response to cytokine IEA
 biological_processGO:0035176 social behavior IBA
 biological_processGO:0042220 response to cocaine IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042711 maternal behavior IBA
 biological_processGO:0042713 sperm ejaculation IEA
 biological_processGO:0042755 eating behavior IEA
 biological_processGO:0043434 response to peptide hormone IEA
 biological_processGO:0044058 regulation of digestive system process IEA
 biological_processGO:0044849 estrous cycle IEA
 biological_processGO:0045777 positive regulation of blood pressure IEA
 biological_processGO:0045907 positive regulation of vasoconstriction IBA
 biological_processGO:0048545 response to steroid hormone IEA
 biological_processGO:0048565 digestive tract development IEA
 biological_processGO:0051965 positive regulation of synapse assembly IEA
 biological_processGO:0051968 positive regulation of synaptic transmission, glutamatergic IEA
 biological_processGO:0060137 maternal process involved in parturition IEA
 biological_processGO:0060406 positive regulation of penile erection IEA
 biological_processGO:0060455 negative regulation of gastric acid secretion IEA
 biological_processGO:0070371 ERK1 and ERK2 cascade IEA
 biological_processGO:0070474 positive regulation of uterine smooth muscle contraction IEA
 biological_processGO:1901652 response to peptide IBA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0005902 microvillus IEA
 cellular_componentGO:0005913 cell-cell adherens junction IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004990 oxytocin receptor activity IEA
 molecular_functionGO:0005000 vasopressin receptor activity IEA
 molecular_functionGO:0017046 peptide hormone binding IEA
 molecular_functionGO:0042277 peptide binding IBA


Pathways (from Reactome)
Pathway description
Vasopressin-like receptors
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000101405 OXT / P01178 / oxytocin/neurophysin I prepropeptide  / reaction / complex






 

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