ENSMUSG00000046707


Mus musculus

Features
Gene ID: ENSMUSG00000046707
  
Biological name :Csnk2a2
  
Synonyms : Casein kinase II subunit alpha / Csnk2a2 / O54833
  
Possible biological names infered from orthology : casein kinase 2 alpha 2 / P19784
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: C5
Gene start: 95446096
Gene end: 95490039
  
Corresponding Affymetrix probe sets: 10580885 (MoGene1.0st)   1419935_s_at (Mouse Genome 430 2.0 Array)   1429301_at (Mouse Genome 430 2.0 Array)   1429302_at (Mouse Genome 430 2.0 Array)   1453099_at (Mouse Genome 430 2.0 Array)   1453100_at (Mouse Genome 430 2.0 Array)   1460646_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000148333
Ensembl peptide - ENSMUSP00000148660
Ensembl peptide - ENSMUSP00000148633
Ensembl peptide - ENSMUSP00000148460
Ensembl peptide - ENSMUSP00000148404
Ensembl peptide - ENSMUSP00000055919
NCBI entrez gene - 13000     See in Manteia.
MGI - MGI:88547
RefSeq - XM_006530641
RefSeq - XM_017312556
RefSeq - XM_006530643
RefSeq - XM_006530642
RefSeq - NM_009974
RefSeq Peptide - NP_034104
swissprot - O54833
swissprot - Q545V8
swissprot - A0A1D5RM74
swissprot - A0A1D5RLE4
swissprot - A0A1D5RLQ2
swissprot - A0A1D5RM55
Ensembl - ENSMUSG00000046707
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 csnk2a2aENSDARG00000012818Danio rerio
 csnk2a2bENSDARG00000013582Danio rerio
 P21869ENSGALG00000031718Gallus gallus
 P19784ENSG00000070770Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q60737 / Csnk2a1 / Casein kinase II subunit alpha / P68400* / Q8NEV1* / CSNK2A3* / casein kinase 2 alpha 1* / casein kinase 2 alpha 3*ENSMUSG0000007469881
Q60737 / Gm10031 / predicted pseudogene 10031 / Q8NEV1* / P68400* / CSNK2A1* / CSNK2A3* / casein kinase 2 alpha 1* / casein kinase 2 alpha 3*ENSMUSG0000010152381


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0021987 cerebral cortex development IEA
 biological_processGO:0051726 regulation of cell cycle IDA
 biological_processGO:0097421 liver regeneration IEA
 biological_processGO:1903146 regulation of autophagy of mitochondrion IEA
 biological_processGO:1903955 positive regulation of protein targeting to mitochondrion IEA
 biological_processGO:1905818 regulation of chromosome separation IEA
 cellular_componentGO:0000785 chromatin IEA
 cellular_componentGO:0001669 acrosomal vesicle IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005956 protein kinase CK2 complex TAS
 cellular_componentGO:0031519 PcG protein complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0047485 protein N-terminus binding IEA


Pathways (from Reactome)
Pathway description
Synthesis of PC
WNT mediated activation of DVL
Condensation of Prometaphase Chromosomes
Signal transduction by L1
Regulation of TP53 Activity through Phosphorylation
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Receptor Mediated Mitophagy
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Regulation of PTEN stability and activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002674 abnormal sperm motility "anomalies in the mobility of the spermatozoa" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002686 globozoospermia "malformation of the acrosome resulting in a round sperm head" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005578 teratozoospermia "presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0009230 abnormal sperm head morphology "any structural abnormality of the head segment of the sperm cell which contains the nucleus with densely coiled chromatin fibers, and is surrounded anteriorly by the acrosome which contains enzymes used for penetrating the female egg" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0009231 detached acrosome "detachment or loss of adhesion of the acrosome cap from the sperm head nucleus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0009232 abnormal sperm nucleus morphology "any structural abnormality of the sperm head nucleus, including an abnormal nuclear shape or defects in the compaction of nuclear chromatin" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0009237 kinked sperm flagellum "a sharp bend or zigzag in the sperm tail" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027067 Ssrp1 / Q08943 / FACT complex subunit SSRP1 / Q08945* / structure specific recognition protein 1*  / reaction / complex
 ENSMUSG00000025040 Fundc1 / Q9DB70 / FUN14 domain-containing protein 1 / Q8IVP5* / FUN14 domain containing 1*  / reaction
 ENSMUSG00000101523 Q60737 / Gm10031 / predicted pseudogene 10031 / Q8NEV1* / P68400* / CSNK2A1* / CSNK2A3* / casein kinase 2 alpha 1* / casein kinase 2 alpha 3*  / complex
 ENSMUSG00000035726 Supt16 / suppressor of Ty 16 / Q9Y5B9* / SUPT16H* / SPT16 homolog, facilitates chromatin remodeling subunit*  / reaction / complex
 ENSMUSG00000059552 Trp53 / P02340 / transformation related protein 53 / TP53* / P04637* / tumor protein p53*  / reaction
 ENSMUSG00000013663 Pten / O08586 / phosphatase and tensin homolog / P60484*  / reaction
 ENSMUSG00000009030 Pdcl / Q9DBX2 / Phosducin-like protein / Q13371* / phosducin like*  / reaction
 ENSMUSG00000029071 Dvl1 / P51141 / Segment polarity DVL-1 / O14640* / dishevelled segment polarity protein 1*  / reaction
 ENSMUSG00000020888 Dvl2 / Q60838 / Segment polarity DVL-2 / O14641* / dishevelled segment polarity protein 2*  / reaction
 ENSMUSG00000046707 O54833 / Csnk2a2 / Casein kinase II subunit alpha / P19784* / casein kinase 2 alpha 2*  / complex
 ENSMUSG00000024387 Csnk2b / P67871 / Casein kinase II subunit beta / P67870* / casein kinase 2 beta*  / complex
 ENSMUSG00000003233 Dvl3 / Q61062 / Segment polarity DVL-3 / Q92997* / dishevelled segment polarity protein 3*  / reaction
 ENSMUSG00000030688 Q9JMD3 / Stard10 / START domain containing 10 / Q9Y365* / StAR related lipid transfer domain containing 10*  / reaction






 

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