ENSG00000070770


Homo sapiens

Features
Gene ID: ENSG00000070770
  
Biological name :CSNK2A2
  
Synonyms : casein kinase 2 alpha 2 / CSNK2A2 / P19784
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: -1
Band: q21
Gene start: 58157907
Gene end: 58197920
  
Corresponding Affymetrix probe sets: 203575_at (Human Genome U133 Plus 2.0 Array)   224922_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000262506
Ensembl peptide - ENSP00000454874
Ensembl peptide - ENSP00000456606
Ensembl peptide - ENSP00000457911
NCBI entrez gene - 1459     See in Manteia.
OMIM - 115442
RefSeq - XM_017022945
RefSeq - NM_001896
RefSeq - XM_005255800
RefSeq - XM_005255801
RefSeq Peptide - NP_001887
swissprot - P19784
swissprot - H3BSA1
swissprot - H3BV19
swissprot - H3BNI9
Ensembl - ENSG00000070770
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 csnk2a2aENSDARG00000012818Danio rerio
 csnk2a2bENSDARG00000013582Danio rerio
 P21869ENSGALG00000031718Gallus gallus
 O54833ENSMUSG00000046707Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P68400 / CSNK2A1 / casein kinase 2 alpha 1ENSG0000010126682
Q8NEV1 / CSNK2A3 / casein kinase 2 alpha 3ENSG0000025459882


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006457 protein folding TAS
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006656 phosphatidylcholine biosynthetic process TAS
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0016236 macroautophagy TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0021987 cerebral cortex development IEA
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:0097421 liver regeneration IEA
 biological_processGO:1901796 regulation of signal transduction by p53 class mediator TAS
 biological_processGO:1903146 regulation of autophagy of mitochondrion IMP
 biological_processGO:1903955 positive regulation of protein targeting to mitochondrion IMP
 biological_processGO:1905818 regulation of chromosome separation IMP
 cellular_componentGO:0000785 chromatin IEA
 cellular_componentGO:0001669 acrosomal vesicle IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0031519 PcG protein complex IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0047485 protein N-terminus binding IPI


Pathways (from Reactome)
Pathway description
Synthesis of PC
WNT mediated activation of DVL
Condensation of Prometaphase Chromosomes
Signal transduction by L1
Regulation of TP53 Activity through Phosphorylation
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Receptor Mediated Mitophagy
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Regulation of PTEN stability and activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000092201 Q9Y5B9 / SUPT16H / SPT16 homolog, facilitates chromatin remodeling subunit  / complex / reaction
 ENSG00000101266 P68400 / CSNK2A1 / casein kinase 2 alpha 1  / complex
 ENSG00000141510 TP53 / P04637 / tumor protein p53  / reaction
 ENSG00000171862 PTEN / P60484 / phosphatase and tensin homolog  / reaction
 ENSG00000069509 FUNDC1 / Q8IVP5 / FUN14 domain containing 1  / reaction
 ENSG00000004975 DVL2 / O14641 / dishevelled segment polarity protein 2  / reaction
 ENSG00000136940 PDCL / Q13371 / phosducin like  / reaction
 ENSG00000198910 L1CAM / P32004 / L1 cell adhesion molecule  / reaction / complex
 ENSG00000070770 P19784 / CSNK2A2 / casein kinase 2 alpha 2  / complex
 ENSG00000204435 CSNK2B / P67870 / casein kinase 2 beta  / complex
 ENSG00000161202 DVL3 / Q92997 / dishevelled segment polarity protein 3  / reaction
 ENSG00000107404 DVL1 / O14640 / dishevelled segment polarity protein 1  / reaction
 ENSG00000214530 Q9Y365 / STARD10 / StAR related lipid transfer domain containing 10  / reaction
 ENSG00000149136 SSRP1 / Q08945 / structure specific recognition protein 1  / reaction / complex






 

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