ENSMUSG00000074698


Mus musculus

Features
Gene ID: ENSMUSG00000074698
  
Biological name :Csnk2a1
  
Synonyms : Casein kinase II subunit alpha / Csnk2a1 / Q60737
  
Possible biological names infered from orthology : casein kinase 2 alpha 1 / casein kinase 2 alpha 3 / CSNK2A3 / P68400 / Q8NEV1
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: G3
Gene start: 152226839
Gene end: 152281852
  
Corresponding Affymetrix probe sets: 10350819 (MoGene1.0st)   10477073 (MoGene1.0st)   1419034_at (Mouse Genome 430 2.0 Array)   1419035_s_at (Mouse Genome 430 2.0 Array)   1419036_at (Mouse Genome 430 2.0 Array)   1419037_at (Mouse Genome 430 2.0 Array)   1419038_a_at (Mouse Genome 430 2.0 Array)   1453427_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000096829
Ensembl peptide - ENSMUSP00000116853
Ensembl peptide - ENSMUSP00000122505
NCBI entrez gene - 12995     See in Manteia.
MGI - MGI:88543
RefSeq - XM_011239272
RefSeq - NM_007788
RefSeq - XM_006498657
RefSeq Peptide - NP_031814
swissprot - Q60737
swissprot - Q6NSS6
swissprot - A2ANR6
Ensembl - ENSMUSG00000074698
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 P21868ENSGALG00000006197Gallus gallus
 P68400ENSG00000101266Homo sapiens
 Q8NEV1ENSG00000254598Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q60737 / Gm10031 / predicted pseudogene 10031 / Q8NEV1* / P68400* / CSNK2A1* / CSNK2A3* / casein kinase 2 alpha 1* / casein kinase 2 alpha 3*ENSMUSG00000101523100
O54833 / Csnk2a2 / Casein kinase II subunit alpha / P19784* / casein kinase 2 alpha 2*ENSMUSG0000004670773


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0008284 positive regulation of cell proliferation ISS
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018107 peptidyl-threonine phosphorylation ISO
 biological_processGO:0030177 positive regulation of Wnt signaling pathway ISS
 biological_processGO:0030307 positive regulation of cell growth ISS
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISS
 biological_processGO:0043666 regulation of phosphoprotein phosphatase activity IEA
 biological_processGO:0045732 positive regulation of protein catabolic process ISS
 biological_processGO:0046777 protein autophosphorylation IDA
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:1905818 regulation of chromosome separation ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005956 protein kinase CK2 complex TAS
 cellular_componentGO:0016580 Sin3 complex ISO
 cellular_componentGO:0016581 NuRD complex ISO
 cellular_componentGO:0031519 PcG protein complex ISS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008013 beta-catenin binding IDA
 molecular_functionGO:0016301 kinase activity ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019888 protein phosphatase regulator activity IDA
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0047485 protein N-terminus binding ISO


Pathways (from Reactome)
Pathway description
Synthesis of PC
WNT mediated activation of DVL
Condensation of Prometaphase Chromosomes
Signal transduction by L1
Regulation of TP53 Activity through Phosphorylation
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Receptor Mediated Mitophagy
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Regulation of PTEN stability and activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000270 abnormal heart tube morphology "malformed embryonic heart " [J:37888]
Show

Allelic Composition: Nck1tm1Paw/Nck1tm1Paw,Nck2tm1Paw/Nck2tm3Paw,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Nck1tm1Paw/Nck1tm1Paw,Nck2tm1Paw/Nck2tm3Paw,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0000288 abnormal pericardium morphology "malformation of the fibroserous membrane covering the heart and beginning of the great vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cml, J:54408]
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Allelic Composition: Nck1tm1Paw/Nck1tm1Paw,Nck2tm1Paw/Nck2tm3Paw,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0000295 poorly developed ventricular trabeculae "retarded differentation of the supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [J:29971]
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Allelic Composition: Nck1tm1Paw/Nck1tm1Paw,Nck2tm1Paw/Nck2tm3Paw,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0000453 absent mouth "missing oral cavity" [J:35802]
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Allelic Composition: Nck1tm1Paw/Nck1tm1Paw,Nck2tm1Paw/Nck2tm3Paw,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0000928 incomplete cephalic closure "arrest of the fusion of the cephalic neural folds" [J:12622]
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Allelic Composition: Nck1tm1Paw/Nck1tm1Paw,Nck2tm1Paw/Nck2tm3Paw,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0000934 abnormal telencephalon development "malformed or incomplete differentiation of the anterior division of the embryonic prosencephalon " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]
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Allelic Composition: Nck1tm1Paw/Nck1tm1Paw,Nck2tm1Paw/Nck2tm3Paw,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Nck1tm1Paw/Nck1tm1Paw,Nck2tm1Paw/Nck2tm3Paw,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Nck1tm1Paw/Nck1tm1Paw,Nck2tm1Paw/Nck2tm3Paw,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0001286 abnormal eye development "malformation or arrest of differentiation of the visual organ" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840]
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Allelic Composition: Nck1tm1Paw/Nck1tm1Paw,Nck2tm1Paw/Nck2tm3Paw,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0001787 pericardial edema "accumulation of watery fluid in the pericardial sac of the heart" [J:52597]
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Allelic Composition: Nck1tm1Paw/Nck1tm1Paw,Nck2tm1Paw/Nck2tm3Paw,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nck1tm1Paw/Nck1tm1Paw,Nck2tm1Paw/Nck2tm3Paw,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0002192 hydrops fetalis "an abnormal accumulation of serous fluid in fetal tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nck1tm1Paw/Nck1tm1Paw,Nck2tm1Paw/Nck2tm3Paw,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0002884 abnormal branchial arches "malformation or anomaly in the transient structures of the embryo that develop into regions of the head, neck and ears" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nck1tm1Paw/Nck1tm1Paw,Nck2tm1Paw/Nck2tm3Paw,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0003425 abnormal optic vesicle formation "anomalous formation of the hollow outgrowth from the lateral aspects of the embryonic forebrain from which the retina and optic nerve develop" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94391]
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Allelic Composition: Nck1tm1Paw/Nck1tm1Paw,Nck2tm1Paw/Nck2tm3Paw,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0003720 abnormal neural tube closure "abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]
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Allelic Composition: Nck1tm1Paw/Nck1tm1Paw,Nck2tm1Paw/Nck2tm3Paw,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0004086 absent heartbeat "lack of a spontaneously beating heart (usually due to defects in the calcium delivery mechanism or loss of a functional contractile apparatus)" [J:69362, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nck1tm1Paw/Nck1tm1Paw,Nck2tm1Paw/Nck2tm3Paw,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0004268 abnormal optic stalk morphology "any structural anomaly of the narrow, proximal portion of the optic vesicle which connects the embryonic eye and forebrain" [ISBN:0-914294-08-3 "Gray s Anatomy"]
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Allelic Composition: Nck1tm1Paw/Nck1tm1Paw,Nck2tm1Paw/Nck2tm3Paw,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0004838 abnormal neural fold elevation formation "any anomaly in the process by which the lateral borders of the neural plate begin to migrate upwards to form the neural folds, caused by the proliferation of the underlying mesoderm" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nck1tm1Paw/Nck1tm1Paw,Nck2tm1Paw/Nck2tm3Paw,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0004937 dilated heart "stretched or widened aperture of the luminal spaces of the heart, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nck1tm1Paw/Nck1tm1Paw,Nck2tm1Paw/Nck2tm3Paw,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0005103 abnormal retinal pigmentation "anomalous coloring of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nck1tm1Paw/Nck1tm1Paw,Nck2tm1Paw/Nck2tm3Paw,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0005650 abnormal limb bud morphology "aberrant structure or development of any of the swellings on the trunk of the embryo that become limbs" [hdene:Howard Dene , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:61460]
Show

Allelic Composition: Nck1tm1Paw/Nck1tm1Paw,Nck2tm1Paw/Nck2tm3Paw,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0006030 abnormal otic vesicle formation "anomalous formation of the simple epithelial sac formed from the otic placode that gives rise to the structures of the inner ear" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:57313:]
Show

Allelic Composition: Nck1tm1Paw/Nck1tm1Paw,Nck2tm1Paw/Nck2tm3Paw,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0006344 small second branchial arch "reduced size of the second branchial arch" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nck1tm1Paw/Nck1tm1Paw,Nck2tm1Paw/Nck2tm3Paw,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0008784 craniorachischisis "congenital fissure of the skull and vertebral column" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Nck1tm1Paw/Nck1tm1Paw,Nck2tm1Paw/Nck2tm3Paw,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Nck1tm1Paw/Nck1tm1Paw,Nck2tm1Paw/Nck2tm3Paw,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0011495 abnormal head shape "any anomaly in the characteristic surface outline or contour of a head of an organism" [MGI:csmith]
Show

Allelic Composition: Nck1tm1Paw/Nck1tm1Paw,Nck2tm1Paw/Nck2tm3Paw,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0012089 decreased midbrain size "size reduction or truncation of the brain region derived from the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions in the adult, including eye movement and coordination of auditory and visual reflexes" [MGI:anna, MGI:csmith]
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Allelic Composition: Nck1tm1Paw/Nck1tm1Paw,Nck2tm1Paw/Nck2tm3Paw,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0012138 decreased forebrain size "size reduction or truncation of the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)" [GO:0048853]
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Allelic Composition: Nck1tm1Paw/Nck1tm1Paw,Nck2tm1Paw/Nck2tm3Paw,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0012263 decreased hindbrain size "size reduction or truncation of the part of the brain developed from the posterior of the three primary brain vesicles of the embryonic neural tube from which the metencephalon and myelencephalon are derived" [MGI:anna]
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Allelic Composition: Nck1tm1Paw/Nck1tm1Paw,Nck2tm1Paw/Nck2tm3Paw,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0012532 abnorrmal surface ectoderm morphology "any structural anomaly of the surface (external) layer of ectoderm which begins to proliferate shortly after separation from the neuroectoderm; cells from the surface ectoderm differentiate to form the epidermis; epithelia lining the mouth and nasal cavities; hair follicles and nails; the lacrimal, tarsal, salivary, sebaceous, sweat, and mammary glands, and anterior pituitary gland (adenohypophysis); inner and outer ear structures; the lens, and conjunctival and corneal epithelia; dental enamel; and the apical ectodermal ridge inducing development of the limb buds" [MGI:anna, UBERON:0000076]
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Allelic Composition: Nck1tm1Paw/Nck1tm1Paw,Nck2tm1Paw/Nck2tm3Paw,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0013180 truncated tail bud "shortened tail bud that terminates in a blunt end (instead of a tapered end)" [MGI:anna]
Show

Allelic Composition: Nck1tm1Paw/Nck1tm1Paw,Nck2tm1Paw/Nck2tm3Paw,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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