ENSMUSG00000006007


Mus musculus

Features
Gene ID: ENSMUSG00000006007
  
Biological name :Pdc
  
Synonyms : Pdc / Phosducin / Q9QW08
  
Possible biological names infered from orthology : P20941
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: G1
Gene start: 150319417
Gene end: 150333906
  
Corresponding Affymetrix probe sets: 10350530 (MoGene1.0st)   1449179_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000140669
Ensembl peptide - ENSMUSP00000141136
Ensembl peptide - ENSMUSP00000140843
Ensembl peptide - ENSMUSP00000131631
NCBI entrez gene - 20028     See in Manteia.
MGI - MGI:98090
RefSeq - NM_001159730
RefSeq - NM_024458
RefSeq Peptide - NP_001153202
RefSeq Peptide - NP_077778
swissprot - Q9QW08
swissprot - A0A087WRK4
swissprot - A0A087WS02
Ensembl - ENSMUSG00000006007
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pdcaENSDARG00000011886Danio rerio
 pdcbENSDARG00000017634Danio rerio
 PDCENSGALG00000030417Gallus gallus
 PDCENSG00000116703Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pdcl / Q9DBX2 / Phosducin-like protein / Q13371* / phosducin like*ENSMUSG0000000903045


Protein motifs (from Interpro)
Interpro ID Name
 IPR001200  Phosducin
 IPR023196  Phosducin, N-terminal domain superfamily
 IPR024253  Phosducin, thioredoxin-like domain
 IPR036249  Thioredoxin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007601 visual perception IEA
 biological_processGO:0008616 queuosine biosynthetic process IBA
 biological_processGO:0050896 response to stimulus IEA
 cellular_componentGO:0001750 photoreceptor outer segment IEA
 cellular_componentGO:0001917 photoreceptor inner segment IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0008479 queuine tRNA-ribosyltransferase activity IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000230 abnormal blood pressure "altered tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cav1tm1Mls/Cav1+,Tg(MMTV-PyVT)634Mul/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL

 MP:0000231 hypertension "sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cav1tm1Mls/Cav1+,Tg(MMTV-PyVT)634Mul/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL

Allelic Composition: Pdctm1Luhe/Pdctm1Luhe
Genetic Background: involves: 129P2/OlaHsd * C3H/HeN * C57BL/6J

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cav1tm1Mls/Cav1+,Tg(MMTV-PyVT)634Mul/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL

 MP:0002127 abnormal cardiovascular system morphology "abnormal development of the heart or vascular tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cav1tm1Mls/Cav1+,Tg(MMTV-PyVT)634Mul/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL

 MP:0002546 mydriasis "dilation of one or both pupils" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cav1tm1Mls/Cav1+,Tg(MMTV-PyVT)634Mul/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL

 MP:0002626 increased heart rate "greater than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Cav1tm1Mls/Cav1+,Tg(MMTV-PyVT)634Mul/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL

 MP:0002975 vascular smooth muscle hypertrophy "increase in size or thickness of the smooth muscle of the vascular wall" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Cav1tm1Mls/Cav1+,Tg(MMTV-PyVT)634Mul/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL

 MP:0003025 increased vascular smooth muscle contraction "greater ability to constrict the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Cav1tm1Mls/Cav1+,Tg(MMTV-PyVT)634Mul/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cav1tm1Mls/Cav1+,Tg(MMTV-PyVT)634Mul/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL

 MP:0005253 abnormal eye physiology "anomalous function and/or activity of the ocular system or any of its parts" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Amhtm1Bhr/Amh+,Amhr2tm1Bhr/Amhr2tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
Show

Allelic Composition: Cav1tm1Mls/Cav1+,Tg(MMTV-PyVT)634Mul/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL

 MP:0005402 abnormal action potential "change in the electric response of a nerve or other excitable tissue to its stimulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cav1tm1Mls/Cav1+,Tg(MMTV-PyVT)634Mul/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL

 MP:0005591 decreased vasodilation "less than the expected or normal widening of the lumen of the blood vessels" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cav1tm1Mls/Cav1+,Tg(MMTV-PyVT)634Mul/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL

 MP:0005600 increased ventricle muscle contractility "greater thant the normal ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Cav1tm1Mls/Cav1+,Tg(MMTV-PyVT)634Mul/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL

 MP:0005665 increased circulating noradrenaline level "greater than the normal blood concentration of this precursor of epinephrine that is a widespread central and autonomic neurotransmitter" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Cav1tm1Mls/Cav1+,Tg(MMTV-PyVT)634Mul/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL

 MP:0006143 increased diastolic blood pressure "abnormal increase in the pressure in the arteries between heart beats when the heart is relaxed" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cav1tm1Mls/Cav1+,Tg(MMTV-PyVT)634Mul/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL

Allelic Composition: Pdctm1Luhe/Pdctm1Luhe
Genetic Background: involves: 129P2/OlaHsd * C3H/HeN * C57BL/6J

 MP:0006144 increased systolic blood pressure "abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cav1tm1Mls/Cav1+,Tg(MMTV-PyVT)634Mul/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL

Allelic Composition: Pdctm1Luhe/Pdctm1Luhe
Genetic Background: involves: 129P2/OlaHsd * C3H/HeN * C57BL/6J

 MP:0006264 decreased systolic blood pressure "abnormal decrease in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:21887]
Show

Allelic Composition: Cav1tm1Mls/Cav1+,Tg(MMTV-PyVT)634Mul/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL

 MP:0008450 retinal photoreceptor degeneration "a retrogressive impairment of function or destruction of a cell specialized to detect and transduce light, including rods and cones of the retina" [MESH:A08.663.650.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gngt1tm1Dgen/Gngt1tm1Dgen,Pdctm1Vya/Pdctm1Vya
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

 MP:0008772 enlarged heart ventricle "increased average size of the heart ventricles compared to the average for a particular population" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cav1tm1Mls/Cav1+,Tg(MMTV-PyVT)634Mul/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cav1tm1Mls/Cav1+,Tg(MMTV-PyVT)634Mul/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL

 MP:0011478 abnormal urine catecholamine level "any anomaly in the urinary amount of catecholamines, including adrenaline, noradrenaline and L-dopamine; catecholamines are act as hormones or neurotransmitters and are derived from the amino acid tyrosine" [MGI:csmith]
Show

Allelic Composition: Cav1tm1Mls/Cav1+,Tg(MMTV-PyVT)634Mul/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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