ENSMUSG00000032064


Mus musculus

Features
Gene ID: ENSMUSG00000032064
  
Biological name :Dixdc1
  
Synonyms : Dixdc1 / Dixin / Q80Y83
  
Possible biological names infered from orthology : DIX domain containing 1 / Q155Q3
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: A5.3
Gene start: 50662752
Gene end: 50739517
  
Corresponding Affymetrix probe sets: 10593384 (MoGene1.0st)   1425256_a_at (Mouse Genome 430 2.0 Array)   1435207_at (Mouse Genome 430 2.0 Array)   1443957_at (Mouse Genome 430 2.0 Array)   1444395_at (Mouse Genome 430 2.0 Array)   1459716_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000113934
Ensembl peptide - ENSMUSP00000034566
Ensembl peptide - ENSMUSP00000112431
Ensembl peptide - ENSMUSP00000112654
Ensembl peptide - ENSMUSP00000113089
Ensembl peptide - ENSMUSP00000113907
NCBI entrez gene - 330938     See in Manteia.
MGI - MGI:2679721
RefSeq - XM_017313441
RefSeq - NM_001311069
RefSeq - NM_178118
RefSeq - XM_006510456
RefSeq - XM_006510457
RefSeq - XM_017313439
RefSeq - XM_017313440
RefSeq - XM_006510451
RefSeq - XM_006510454
RefSeq - XM_006510455
RefSeq Peptide - NP_001297998
RefSeq Peptide - NP_835219
swissprot - Q80Y83
swissprot - F2Z453
Ensembl - ENSMUSG00000032064
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dixdc1aENSDARG00000025302Danio rerio
 dixdc1bENSDARG00000056267Danio rerio
 DIXDC1ENSGALG00000007929Gallus gallus
 DIXDC1ENSG00000150764Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dvl1 / P51141 / Segment polarity DVL-1 / O14640* / dishevelled segment polarity protein 1*ENSMUSG0000002907112
Dvl3 / Q61062 / Segment polarity DVL-3 / Q92997* / dishevelled segment polarity protein 3*ENSMUSG0000000323312
Dvl2 / Q60838 / Segment polarity DVL-2 / O14641* / dishevelled segment polarity protein 2*ENSMUSG0000002088811


Protein motifs (from Interpro)
Interpro ID Name
 IPR001158  DIX domain
 IPR001715  Calponin homology domain
 IPR015506  Dishevelled-related protein
 IPR029071  Ubiquitin-like domain superfamily
 IPR036872  CH domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007049 cell cycle IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0021795 cerebral cortex cell migration IMP
 biological_processGO:0021799 cerebral cortex radially oriented cell migration IMP
 biological_processGO:0021846 cell proliferation in forebrain IMP
 biological_processGO:0021869 forebrain ventricular zone progenitor cell division IMP
 biological_processGO:0030177 positive regulation of Wnt signaling pathway IMP
 biological_processGO:0032956 regulation of actin cytoskeleton organization IMP
 biological_processGO:0045665 negative regulation of neuron differentiation IMP
 biological_processGO:0060070 canonical Wnt signaling pathway IMP
 biological_processGO:0070507 regulation of microtubule cytoskeleton organization IMP
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0030054 cell junction IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0043015 gamma-tubulin binding ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Mcutm1.1Jmol/Mcutm1.1Jmol,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Mcutm1.1Jmol/Mcutm1.1Jmol,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Mcutm1.1Jmol/Mcutm1.1Jmol,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Macrod2tm1.1(KOMP)Vlcg/Macrod2tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Macrod2tm1.1(KOMP)Vlcg/J

Allelic Composition: Dixdc1tm1Bnrc/Dixdc1tm1Bnrc
Genetic Background: involves: 129 * C57BL/6

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Macrod2tm1.1(KOMP)Vlcg/Macrod2tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Macrod2tm1.1(KOMP)Vlcg/J

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Macrod2tm1.1(KOMP)Vlcg/Macrod2tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Macrod2tm1.1(KOMP)Vlcg/J

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Dixdc1tm1Bnrc/Dixdc1tm1Bnrc
Genetic Background: involves: 129 * C57BL/6

 MP:0005103 abnormal retinal pigmentation "anomalous coloring of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Macrod2tm1.1(KOMP)Vlcg/Macrod2tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Macrod2tm1.1(KOMP)Vlcg/J

Allelic Composition: Dixdc1tm1.1(KOMP)Vlcg/Dixdc1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Dixdc1tm1.1(KOMP)Vlcg/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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