ENSMUSG00000003308


Mus musculus

Features
Gene ID: ENSMUSG00000003308
  
Biological name :Keap1
  
Synonyms : Keap1 / Kelch-like ECH-associated protein 1 / Q9Z2X8
  
Possible biological names infered from orthology : Q14145
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: A3
Gene start: 21229730
Gene end: 21239361
  
Corresponding Affymetrix probe sets: 10591482 (MoGene1.0st)   1450746_at (Mouse Genome 430 2.0 Array)   1450747_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000131029
Ensembl peptide - ENSMUSP00000141840
Ensembl peptide - ENSMUSP00000149705
Ensembl peptide - ENSMUSP00000062467
Ensembl peptide - ENSMUSP00000141807
NCBI entrez gene - 50868     See in Manteia.
MGI - MGI:1858732
RefSeq - NM_001110305
RefSeq - NM_001110306
RefSeq - NM_001110307
RefSeq - NM_016679
RefSeq Peptide - NP_001103775
RefSeq Peptide - NP_001103776
RefSeq Peptide - NP_001103777
RefSeq Peptide - NP_057888
swissprot - Q9Z2X8
swissprot - A0A1L1SS10
Ensembl - ENSMUSG00000003308
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 keap1bENSDARG00000074634Danio rerio
 KEAP1ENSG00000079999Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Klhl20 / Q8VCK5 / Kelch-like protein 20 / Q9Y2M5* / kelch like family member 20*ENSMUSG0000002670535
Q6TDP3 / Plekhn1 / Kelch-like protein 17 / KLHL17* / Q6TDP4* / kelch like family member 17*ENSMUSG0000007848535
Klhl3 / E0CZ16 / Kelch-like protein 3 / Q9UH77* / kelch like family member 3*ENSMUSG0000001416434
Klhl2 / Q8JZP3 / Kelch-like protein 2 / O95198* / kelch like family member 2*ENSMUSG0000003160534
Klhl5 / Mus musculus kelch-like 5 (Klhl5), transcript variant 2, mRNA. / Q96PQ7* / kelch like family member 5*ENSMUSG0000005492033
Klhl1 / Q9JI74 / Kelch-like protein 1 / Q9NR64* / kelch like family member 1*ENSMUSG0000002207633
Klhl12 / Q8BZM0 / Kelch-like protein 12 / Q53G59* / kelch like family member 12*ENSMUSG0000002645533
Klhl4 / kelch-like protein 4 isoform 3 / Q9C0H6* / kelch like family member 4*ENSMUSG0000002559732
Klhl28 / Q9CR40 / Kelch-like protein 28 / Q9NXS3* / kelch like family member 28*ENSMUSG0000002094832
Klhl18 / kelch like family member 18 / O94889*ENSMUSG0000005479231
Klhl8 / P59280 / Kelch-like protein 8 / Q9P2G9* / kelch like family member 8*ENSMUSG0000002931229
Klhl10 / Q9D5V2 / kelch-like 10 / Q6JEL2* / kelch like family member 10*ENSMUSG0000000155828


Protein motifs (from Interpro)
Interpro ID Name
 IPR000210  BTB/POZ domain
 IPR006652  Kelch repeat type 1
 IPR011333  SKP1/BTB/POZ domain superfamily
 IPR011705  BTB/Kelch-associated
 IPR015915  Kelch-type beta propeller
 IPR017096  BTB-kelch protein
 IPR030563  Kelch-like ECH-associated protein 1
 IPR037293  Galactose oxidase, central domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IMP
 biological_processGO:0010499 proteasomal ubiquitin-independent protein catabolic process ISO
 biological_processGO:0016567 protein ubiquitination ISO
 biological_processGO:0042994 cytoplasmic sequestering of transcription factor IBA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IBA
 biological_processGO:0045604 regulation of epidermal cell differentiation IMP
 biological_processGO:0071353 cellular response to interleukin-4 IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005815 microtubule organizing center ISO
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005884 actin filament IDA
 cellular_componentGO:0030496 midbody ISO
 cellular_componentGO:0031463 Cul3-RING ubiquitin ligase complex ISO
 cellular_componentGO:0032991 protein-containing complex IMP
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IBA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IMP
 molecular_functionGO:0097718 disordered domain specific binding IPI


Pathways (from Reactome)
Pathway description
Ub-specific processing proteases
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000468 abnormal esophageal epithelium morphology "malformation of the epithelial layer of the esophagus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
Show

Allelic Composition: Prkntm1Shn/Prkntm1Shn
Genetic Background: involves: 129S4/SvJae

 MP:0000472 abnormal stomach squamous epithelium morphology "malformation of the scaly epithelial layer of the stomach" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc, J:54637]
Show

Allelic Composition: Prkntm1Shn/Prkntm1Shn
Genetic Background: involves: 129S4/SvJae

 MP:0000473 abnormal stomach glandular epithelium morphology "malformation of the gland-containing epithelial layer of the stomach" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc, J:54637]
Show

Allelic Composition: Prkntm1Shn/Prkntm1Shn
Genetic Background: involves: 129S4/SvJae

 MP:0001192 scaly skin "skin covered with shedding scales or flakes" [J:65146]
Show

Allelic Composition: Prkntm1Shn/Prkntm1Shn
Genetic Background: involves: 129S4/SvJae

 MP:0001242 hyperkeratosis "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]
Show

Allelic Composition: Prkntm1Shn/Prkntm1Shn
Genetic Background: involves: 129S4/SvJae

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Prkntm1Shn/Prkntm1Shn
Genetic Background: involves: 129S4/SvJae

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Prkntm1Shn/Prkntm1Shn
Genetic Background: involves: 129S4/SvJae

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Prkntm1Shn/Prkntm1Shn
Genetic Background: involves: 129S4/SvJae

 MP:0002691 small stomach "reduced size of the stomach" [J:77398, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prkntm1Shn/Prkntm1Shn
Genetic Background: involves: 129S4/SvJae

 MP:0005166 decreased susceptiblity to injury "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rbpjtm1Hon/Rbpjtm1.1Hon,Shhtm2(cre/ERT2)Cjt/Shh+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0005211 increased thickness of gastric mucosa "greater than the normal depth or width of the epithelial layer of the stomach" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:77398]
Show

Allelic Composition: Prkntm1Shn/Prkntm1Shn
Genetic Background: involves: 129S4/SvJae

 MP:0006382 abnormal lung epithelium morphology "any structural anomaly of the epithelial layer of the lung" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rbpjtm1Hon/Rbpjtm1.1Hon,Shhtm2(cre/ERT2)Cjt/Shh+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Keap1tm1Mym/Keap1tm2Mym,Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0009767 decreased sensitivity to xenobiotic induced morbidity/mortality "increase in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Keap1tm1Mym/Keap1tm2Mym,Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0010809 abnormal Clara cell morphology "any structural anomaly of the rounded, club-shaped, nonciliated cell protruding between ciliated cells in bronchiolar epithelium, believed to be secretory in function" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Rbpjtm1Hon/Rbpjtm1.1Hon,Shhtm2(cre/ERT2)Cjt/Shh+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Prkntm1Shn/Prkntm1Shn
Genetic Background: involves: 129S4/SvJae

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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