ENSMUSG00000018486


Mus musculus

Features
Gene ID: ENSMUSG00000018486
  
Biological name :Wnt9b
  
Synonyms : O35468 / wingless-type MMTV integration site family, member 9B / Wnt9b
  
Possible biological names infered from orthology : O14905 / Wnt family member 9B
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: E1
Gene start: 103727364
Gene end: 103749821
  
Corresponding Affymetrix probe sets: 10391957 (MoGene1.0st)   1443197_at (Mouse Genome 430 2.0 Array)   1451711_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000018630
NCBI entrez gene - 22412     See in Manteia.
MGI - MGI:1197020
RefSeq - NM_011719
RefSeq Peptide - NP_035849
swissprot - O35468
swissprot - Q2TBA6
Ensembl - ENSMUSG00000018486
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 wnt9bENSDARG00000037889Danio rerio
 WNT9BENSGALG00000001097Gallus gallus
 WNT9BENSG00000158955Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Wnt9a / Q8R5M2 / wingless-type MMTV integration site family, member 9A / O14904* / Wnt family member 9A*ENSMUSG0000000012661
P48614 / Wnt10b / wingless-type MMTV integration site family, member 10B / O00744* / Wnt family member 10B*ENSMUSG0000002299635
P70701 / Wnt10a / wingless-type MMTV integration site family, member 10A / Q9GZT5* / Wnt family member 10A*ENSMUSG0000002616735
Wnt8b / wingless-type MMTV integration site family, member 8B / Q93098* / Wnt family member 8B*ENSMUSG0000003696133
Wnt8a / Q64527 / wingless-type MMTV integration site family, member 8A / Q9H1J5* / Wnt family member 8A*ENSMUSG0000001228231


Protein motifs (from Interpro)
Interpro ID Name
 IPR005817  Wnt
 IPR018161  Wnt protein, conserved site
 IPR026535  Wnt-9b protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001658 branching involved in ureteric bud morphogenesis IMP
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0001822 kidney development IMP
 biological_processGO:0001932 regulation of protein phosphorylation IMP
 biological_processGO:0003339 regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis IMP
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0009267 cellular response to starvation IEP
 biological_processGO:0009786 regulation of asymmetric cell division IMP
 biological_processGO:0009887 animal organ morphogenesis TAS
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0016055 Wnt signaling pathway IMP
 biological_processGO:0030182 neuron differentiation IBA
 biological_processGO:0030539 male genitalia development IMP
 biological_processGO:0035150 regulation of tube size IMP
 biological_processGO:0043085 positive regulation of catalytic activity IMP
 biological_processGO:0045165 cell fate commitment IBA
 biological_processGO:0048701 embryonic cranial skeleton morphogenesis IMP
 biological_processGO:0048754 branching morphogenesis of an epithelial tube IMP
 biological_processGO:0060021 roof of mouth development IMP
 biological_processGO:0060070 canonical Wnt signaling pathway IEA
 biological_processGO:0060071 Wnt signaling pathway, planar cell polarity pathway IMP
 biological_processGO:0060993 kidney morphogenesis IMP
 biological_processGO:0061038 uterus morphogenesis IMP
 biological_processGO:0072003 kidney rudiment formation IMP
 biological_processGO:0072038 mesenchymal stem cell maintenance involved in nephron morphogenesis IMP
 biological_processGO:0072044 collecting duct development IMP
 biological_processGO:0072046 establishment of planar polarity involved in nephron morphogenesis IMP
 biological_processGO:0072078 nephron tubule morphogenesis IMP
 biological_processGO:0072164 mesonephric tubule development IMP
 biological_processGO:0072170 metanephric tubule development IMP
 biological_processGO:0072174 metanephric tubule formation IMP
 biological_processGO:0072181 mesonephric duct formation IMP
 biological_processGO:1902455 negative regulation of stem cell population maintenance IEA
 biological_processGO:1904948 midbrain dopaminergic neuron differentiation IEA
 biological_processGO:1905438 non-canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:1990851 Wnt-Frizzled-LRP5/6 complex IC
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005109 frizzled binding IBA
 molecular_functionGO:0039706 co-receptor binding IPI
 molecular_functionGO:0048018 receptor ligand activity IEA


Pathways (from Reactome)
Pathway description
WNT ligand biogenesis and trafficking


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Dicer1tm1.1Bdh/Dicer1tm1.1Bdh
Genetic Background: involves: 129

Allelic Composition: Wnt9btm1Amc/Wnt9btm1Amc,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

Allelic Composition: Pbx1tm1Mlc/Pbx1+,Wnt9btm1Amc/Wnt9btm1Amc,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129X1/SvJ

 MP:0000527 abnormal kidney development "anomalous differentiation of the paired organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dicer1tm1.1Bdh/Dicer1tm1.1Bdh
Genetic Background: involves: 129

Allelic Composition: Gt(ROSA)26Sortm2(Wnt1/GFP)Amc/Gt(ROSA)26Sor+,Wnt9btm1.1Amc/Wnt9btm1.1Amc
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Six2tm1Gco/Six2tm1Gco,Wnt9btm1.1Amc/Wnt9btm1.1Amc
Genetic Background: involves: 129X1/SvJ * C57BL/6J * NMRI

Allelic Composition: Wnt9btm1.1Amc/Wnt9btm1.1Amc
Genetic Background: involves: 129X1/SvJ * C57BL/6J * NMRI

Allelic Composition: Six2tm1Gco/Six2tm1Gco,Wnt9btm1.1Amc/Wnt9btm1.1Amc
Genetic Background: involves: 129/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Wnt9btm1.1Amc/Wnt9btm1.1Amc
Genetic Background: involves: 129/Sv * 129X1/SvJ * C57BL/6J

 MP:0000528 delayed kidney development "late onset of the induction and/or differentiation of the kidney" [J:18048]
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Allelic Composition: Six2tm1Gco/Six2tm1Gco,Wnt9btm1.1Amc/Wnt9btm1.1Amc
Genetic Background: involves: 129/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Wnt9btm1.1Amc/Wnt9btm1.1Amc
Genetic Background: involves: 129/Sv * 129X1/SvJ * C57BL/6J

 MP:0002058 neonatal lethality "death of animal within one day after birth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dicer1tm1.1Bdh/Dicer1tm1.1Bdh
Genetic Background: involves: 129

Allelic Composition: Gt(ROSA)26Sortm2(Wnt1/GFP)Amc/Gt(ROSA)26Sor+,Wnt9btm1.1Amc/Wnt9btm1.1Amc
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Wnt9btm1.1Amc/Wnt9btm1.1Amc
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Wnt9btm1.1Amc/Wnt9btm1.2Amc,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129X1/SvJ * ICR

Allelic Composition: Wnt9btm1.1Amc/Wnt9btm1.2Amc,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0002703 abnormal renal tubules "anomalous structure or development of the loops of Henle and collecting ducts in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Wnt9btm1.1Amc/Wnt9btm1.1Amc
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0002705 dilated renal tubules "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Wnt9btm1.1Amc/Wnt9btm1.1Amc
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Wnt9btm1.1Amc/Wnt9btm1.2Amc,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129X1/SvJ * ICR

 MP:0002989 small kidney "reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Wnt9btm1.1Amc/Wnt9btm1.1Amc
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Wnt9btm1Amc/Wnt9btm1Amc
Genetic Background: involves: 129X1/SvJ

 MP:0003557 absent vas deferens "absence of the secretory duct of the testicle that carries spermatozoa, running from the epididymis, of which it is the continuation, to the prostatic urethra where it terminates to form ejaculatory duct" [ncbi:Matthew Mailman, NCBI request, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Wnt9btm1.1Amc/Wnt9btm1.1Amc
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0003558 absent uterus "absence of the female muscular organ of gestation" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Wnt9btm1.1Amc/Wnt9btm1.1Amc
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0003576 oviduct hypoplasia "reduced size of the tube through which the ova pass from the ovary to the uterus due to decreased cell number" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Wnt9btm1.1Amc/Wnt9btm1.1Amc
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0003675 kidney cysts "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Wnt9btm1Amc/Wnt9btm1Amc
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Wnt9btm1.1Amc/Wnt9btm1.2Amc,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129X1/SvJ * ICR

Allelic Composition: Wnt9btm1.1Amc/Wnt9btm1.2Amc,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Wnt9btm1.1Amc/Wnt9btm1.2Amc,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129X1/SvJ * ICR

 MP:0003826 abnormal Mullerian duct morphology "malformation of the transient embryonic tubes that empty into the cloaca and in the female develop into the oviducts, uterus, and vagina" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Wnt9btm1.1Amc/Wnt9btm1.1Amc
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Gt(ROSA)26Sortm2(Wnt1/GFP)Amc/Gt(ROSA)26Sor+,Wnt9btm1.1Amc/Wnt9btm1.1Amc
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0004727 absent epididymis "absence of the elongated structure connected to the posterior surface of the testis, consisting of the head, body, and tail, which turns sharply on itself to become the ductus deferens (vas deferens)" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Wnt9btm1.1Amc/Wnt9btm1.1Amc
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0004754 abnormal kidney collecting duct "any structural anomaly of the duct that drains fluid from the nephron and either allows bodily reabsorbtion of water or allows the fluid to drain to the bladder via the ureter; the collecting duct system also maintains acid-base homeostasis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Wnt9btm1.1Amc/Wnt9btm1.1Amc
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Gt(ROSA)26Sortm2(Wnt1/GFP)Amc/Gt(ROSA)26Sor+,Wnt9btm1.1Amc/Wnt9btm1.1Amc
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0004936 abnormal ureteric bud branching morphogenesis "partial or complete failure of the ureteric bud to repeatedly divide into lobules during development of the kidney" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Wnt9btm1.1Amc/Wnt9btm1.1Amc
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0005170 cleft lip "defect in the upper lip where the maxillary prominence fails to merge with the merged medial nasal prominences" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ercc8tm1Jhjh/Ercc8tm1Jhjh,Xpctm1Ecf/Xpc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Wnt9bclf1/Wnt9bclf1,clf2/clf2
Genetic Background: AEJ.A/Jur

Allelic Composition: Wnt9bclf1/Wnt9bclf1,clf2/clf2+
Genetic Background: AEJ.A/Jur

Allelic Composition: Wnt9btm1.1Amc/Wnt9btm1.1Amc
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Wnt9btm1Amc/Wnt9btm1Amc,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

Allelic Composition: Pbx1tm1Mlc/Pbx1+,Wnt9btm1Amc/Wnt9btm1Amc,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129X1/SvJ

 MP:0006032 abnormal ureteric bud morphology "anomaly in the formation or development of the ureteric bud that with the metanephric mesenchyme gives rise to the kidneys " [smb:Susan M Bello, Mouse Genome Informatics Curator, J:57313:]
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Allelic Composition: Wnt9btm1.1Amc/Wnt9btm1.1Amc
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0009072 absent cranial vagina "absence of the upper third of the female reproductive canal located between the uterus and the vulva, usually due to a developmental arrest or agenesis of the caudal Mullerian ducts" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Wnt9btm1.1Amc/Wnt9btm1.1Amc
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0009073 absent Wolffian ducts "absence of the transient embryonic drainage tubes of the embryonic kidney (mesonephric tubules) that empty into the cloaca and later develop into the ductus deferens in the male" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Wnt9btm1.1Amc/Wnt9btm1.1Amc
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0009640 abnormal renal tubule epithelium morphology "any structural anomaly of the cellular avascular layer of the renal tubule luminar surfaces" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Wnt9btm1.1Amc/Wnt9btm1.2Amc,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129X1/SvJ * ICR

 MP:0011682 renal glomerulus cysts "abnormal membranous sacs in any portion of the renal glomerulus" [MGI:csmith]
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Allelic Composition: Wnt9btm1Amc/Wnt9btm1Amc
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Wnt9btm1.1Amc/Wnt9btm1.2Amc,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129X1/SvJ * ICR

 MP:0011843 abnormal kidney collecting duct epithelium morphology "any structural anomaly of the simple cuboidal epithelium lining the lumen of kidney collecting ducts; the mature and differentiated CD epithelium comprises two unique cells types with principal cells responsible for vasopressin-regulated water reabsorption, and intercalated cells regulating acid-base homeostasis; injury to the epithelium is believed to cause epithelial cells to acquire mesenchymal characteristics via epithelial-mesenchymal transition (EMT), a process through which tubular epithelial cells may transform into interstitial fibroblasts and promote renal fibrosis" [MGI:anna]
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Allelic Composition: Wnt9btm1Amc/Wnt9btm1Amc
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Wnt9btm1.1Amc/Wnt9btm1.2Amc,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129X1/SvJ * ICR

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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