ENSMUSG00000026167


Mus musculus

Features
Gene ID: ENSMUSG00000026167
  
Biological name :Wnt10a
  
Synonyms : P70701 / wingless-type MMTV integration site family, member 10A / Wnt10a
  
Possible biological names infered from orthology : Q9GZT5 / Wnt family member 10A
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: C4
Gene start: 74791516
Gene end: 74804179
  
Corresponding Affymetrix probe sets: 10347497 (MoGene1.0st)   1460657_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000139656
Ensembl peptide - ENSMUSP00000006718
NCBI entrez gene - 22409     See in Manteia.
MGI - MGI:108071
RefSeq - NM_009518
RefSeq Peptide - NP_033544
swissprot - A0A087WP71
swissprot - P70701
Ensembl - ENSMUSG00000026167
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 wnt10aENSDARG00000017155Danio rerio
 WNT10AENSGALG00000011355Gallus gallus
 Q9GZT5ENSG00000135925Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P48614 / Wnt10b / wingless-type MMTV integration site family, member 10B / O00744* / Wnt family member 10B*ENSMUSG0000002299657
Wnt9b / O35468 / wingless-type MMTV integration site family, member 9B / O14905* / Wnt family member 9B*ENSMUSG0000001848630
Wnt8b / wingless-type MMTV integration site family, member 8B / Q93098* / Wnt family member 8B*ENSMUSG0000003696130
Wnt9a / Q8R5M2 / wingless-type MMTV integration site family, member 9A / O14904* / Wnt family member 9A*ENSMUSG0000000012629
Wnt8a / Q64527 / wingless-type MMTV integration site family, member 8A / Q9H1J5* / Wnt family member 8A*ENSMUSG0000001228229


Protein motifs (from Interpro)
Interpro ID Name
 IPR005817  Wnt
 IPR013302  Wnt-10 protein
 IPR018161  Wnt protein, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001942 hair follicle development IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0009887 animal organ morphogenesis TAS
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0014033 neural crest cell differentiation IDA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0030182 neuron differentiation IBA
 biological_processGO:0031069 hair follicle morphogenesis IEA
 biological_processGO:0042476 odontogenesis IEA
 biological_processGO:0042487 regulation of odontogenesis of dentin-containing tooth IDA
 biological_processGO:0043586 tongue development IEA
 biological_processGO:0043588 skin development IEA
 biological_processGO:0045165 cell fate commitment IBA
 biological_processGO:0048730 epidermis morphogenesis IEA
 biological_processGO:0048733 sebaceous gland development IEA
 biological_processGO:0060070 canonical Wnt signaling pathway IEA
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005109 frizzled binding IBA
 molecular_functionGO:0048018 receptor ligand activity IEA


Pathways (from Reactome)
Pathway description
WNT ligand biogenesis and trafficking


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tg(KRT5-rtTA)#Glk/0,Tg(tetO-cre)1Jaw/0,Wnt10atm1Smr/Wnt10atm1Smr
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

 MP:0000380 small hair follicles "reduced size of the invagination of the epidermis from which the hair shaft develops" [J:56777]
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Allelic Composition: Tg(KRT5-rtTA)#Glk/0,Tg(tetO-cre)1Jaw/0,Wnt10atm1Smr/Wnt10atm1Smr
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

 MP:0000392 accelerated hair follicle regression "quicker than average length of time for onset of catagen phase of the cyclic transformation of the hair follicle" [J:65034]
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Allelic Composition: Tg(KRT5-rtTA)#Glk/0,Tg(tetO-cre)1Jaw/0,Wnt10atm1Smr/Wnt10atm1Smr
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

 MP:0000579 abnormal nail morphology "structural or developmental anomaly of any of the thin, horny, translucent plates covering the dorsal surface of the distal end of each terminal phalanx of the digits" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tg(Myh6-2A)#Know/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: BALB/c * C57BL/6 * FVB/N

 MP:0000652 enlarged sebaceous gland "increased size of the sebum secreting glands of the hair shaft" [J:30249]
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Allelic Composition: Tg(KRT5-rtTA)#Glk/0,Tg(tetO-cre)1Jaw/0,Wnt10atm1Smr/Wnt10atm1Smr
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

 MP:0000674 abnormal sweat gland morphology "anomalous structure of any of the coil glands of the skin that secrete sweat" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tg(Myh6-2A)#Know/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: BALB/c * C57BL/6 * FVB/N

Allelic Composition: Tg(KRT5-rtTA)#Glk/0,Tg(tetO-cre)1Jaw/0,Wnt10atm1Smr/Wnt10atm1Smr
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

 MP:0000762 abnormal tongue morphology "anomalous structure or development of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tg(Myh6-2A)#Know/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: BALB/c * C57BL/6 * FVB/N

Allelic Composition: Tg(KRT5-rtTA)#Glk/0,Tg(tetO-cre)1Jaw/0,Wnt10atm1Smr/Wnt10atm1Smr
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

 MP:0000763 abnormal filiform papillae "malformed keratinized projections on the dorsal surface of the tongue" [J:45400]
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Allelic Composition: Tg(Myh6-2A)#Know/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: BALB/c * C57BL/6 * FVB/N

Allelic Composition: Tg(KRT5-rtTA)#Glk/0,Tg(tetO-cre)1Jaw/0,Wnt10atm1Smr/Wnt10atm1Smr
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

 MP:0001002 abnormal taste bud morphology "anomalous structure of the small sensory organs located in the tongue that contain gustatory receptor cells, basal cells, and supporting cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tg(Myh6-2A)#Know/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: BALB/c * C57BL/6 * FVB/N

Allelic Composition: Tg(KRT5-rtTA)#Glk/0,Tg(tetO-cre)1Jaw/0,Wnt10atm1Smr/Wnt10atm1Smr
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

 MP:0001539 decreased number of caudal vertebrae "reduced number of the bony segments of the tail" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Trip13tm1.1(KOMP)Vlcg/Trip13tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Trip13tm1.1(KOMP)Vlcg/Ucd

 MP:0002689 abnormal molar morphology "structural defect of the most posterior teeth located on either side of the jaw, and characterized by a large crown and broad chewing surface" [il:Ira Lu , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tg(Myh6-2A)#Know/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: BALB/c * C57BL/6 * FVB/N

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Trip13tm1.1(KOMP)Vlcg/Trip13tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Trip13tm1.1(KOMP)Vlcg/Ucd

 MP:0002818 abnormal dentin morphology "defects in the hard portion of the tooth surrounding the pulp, covered by enamel on the crown and cementum on the root" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Adktm2Bois/Adktm2Bois,Adora1tm1Bbf/Adora1tm1Bbf,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0002992 abnormal sebaceous lipid secretion "abnormal function of the sebaceous gland resulting in changes to the lipid profile secreted onto the hair and skin" [smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Tg(KRT5-rtTA)#Glk/0,Tg(tetO-cre)1Jaw/0,Wnt10atm1Smr/Wnt10atm1Smr
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

 MP:0003931 absent molars "missing the most posterior teeth located on either side of the jaw, and characterized by a large crown and broad chewing surface" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tg(Myh6-2A)#Know/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: BALB/c * C57BL/6 * FVB/N

 MP:0003932 abnormal molar crown morphology "defects in the upper part of the molar, which is normally covered with enamel " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Adktm2Bois/Adktm2Bois,Adora1tm1Bbf/Adora1tm1Bbf,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0004189 abnormal alveolar process "any structural anomaly of the thickened ridge of bone in the mandible and maxilla that holds the tooth sockets" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tg(Myh6-2A)#Know/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: BALB/c * C57BL/6 * FVB/N

 MP:0005358 abnormal incisor morphology "structural defect of the long pointed teeth; most anterior and prominent in the jaw" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85574]
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Allelic Composition: Adktm2Bois/Adktm2Bois,Adora1tm1Bbf/Adora1tm1Bbf,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0006257 abnormal fungiform papillae "malformation, absence, or atypical size or shape of the mushroom-shaped papillae, which have a single tase bud at the tip, located mostly on the dorsal anterior portion of the tongue " [smb:Susan M Bello, Mouse Genome Informatics Curator, J:55127]
Show

Allelic Composition: Tg(Myh6-2A)#Know/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: BALB/c * C57BL/6 * FVB/N

Allelic Composition: Tg(KRT5-rtTA)#Glk/0,Tg(tetO-cre)1Jaw/0,Wnt10atm1Smr/Wnt10atm1Smr
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

 MP:0006402 small molars "reduced size of the most posterior teeth located on either side of the jaw, and characterized by a large crown and broad chewing surface" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adktm2Bois/Adktm2Bois,Adora1tm1Bbf/Adora1tm1Bbf,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Wnt10atm1.1Smr/Wnt10atm1.1Smr
Genetic Background: involves: 129X1/SvJ * BALB/cJ

 MP:0008858 abnormal hair cycle anagen phase "anomaly in the growth phase of the hair cycle" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tg(KRT5-rtTA)#Glk/0,Tg(tetO-cre)1Jaw/0,Wnt10atm1Smr/Wnt10atm1Smr
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

 MP:0010773 supernumerary molars "increased number of the most posterior teeth located on either side of the jaw, and characterized by a large crown and broad chewing surface" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Adktm2Bois/Adktm2Bois,Adora1tm1Bbf/Adora1tm1Bbf,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Wnt10atm1.1Smr/Wnt10atm1.1Smr
Genetic Background: involves: 129X1/SvJ * BALB/cJ

Allelic Composition: Wnt10atm1Smr/Wnt10atm1Smr,Tg(KRT14-cre)#Smr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * SJL/J

 MP:0011194 abnormal hair follicle physiology "any functional anomaly of the invagination of the epidermis from which the hair shaft develops" [MESH:A10.272.497.500, MGI:mnk]
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Allelic Composition: Tg(KRT5-rtTA)#Glk/0,Tg(tetO-cre)1Jaw/0,Wnt10atm1Smr/Wnt10atm1Smr
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

 MP:0011941 increased fluid intake "increase in the total amount of fluid taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Wnt10atm1.1Smr/Wnt10atm1.1Smr
Genetic Background: involves: 129X1/SvJ * BALB/cJ

 MP:0013371 hypohidrosis "decreased sweating in response to appropriate stimuli" [MGI:Anna]
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Allelic Composition: Tg(KRT5-rtTA)#Glk/0,Tg(tetO-cre)1Jaw/0,Wnt10atm1Smr/Wnt10atm1Smr
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

 MP:0030451 abnormal dentin mineralization "anomaly in the process by which calcium salts are deposited into dentin" [GO:0097188]
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Allelic Composition: Adktm2Bois/Adktm2Bois,Adora1tm1Bbf/Adora1tm1Bbf,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0030457 abnormal molar cusp morphology "any structural anomaly of an elevation or mound on the crown of a molar tooth making up a part of the occlusal (masticatory) surface" [https://medical-dictionary.thefreedictionary.com/cusp+of+tooth, MGI:anna]
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Allelic Composition: Adktm2Bois/Adktm2Bois,Adora1tm1Bbf/Adora1tm1Bbf,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Wnt10atm1.1Smr/Wnt10atm1.1Smr
Genetic Background: involves: 129X1/SvJ * BALB/cJ

Allelic Composition: Wnt10atm1Smr/Wnt10atm1Smr,Tg(KRT14-cre)#Smr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * SJL/J

 MP:0030491 dental pulp stones "nodular, calcified masses appearing in either or both the coronal and root portion of the pulp organ in teeth" [HP:0003771, https://en.wikipedia.org/wiki/Pulp_stone]
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Allelic Composition: Adktm2Bois/Adktm2Bois,Adora1tm1Bbf/Adora1tm1Bbf,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0030494 abnormal molar root morphology "any structural anomaly of the part of a molar tooth that is implanted in the gum" [MGI:anna]
Show

Allelic Composition: Wnt10atm1.1Smr/Wnt10atm1.1Smr
Genetic Background: involves: 129X1/SvJ * BALB/cJ

Allelic Composition: Wnt10atm1Smr/Wnt10atm1Smr,Tg(KRT14-cre)#Smr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * SJL/J

 MP:0030496 taurodontia "a developmental anomaly involving molar teeth, whereby the body of the tooth and pulp chamber is enlarged vertically at the expense of the roots and the root canal length; characteristic features include an enlarged pulp chamber, absence of the usual constriction at the cemento-enamel junction, and apical shift of the pulp chamber floor and furcation area down the root" [https://en.wikipedia.org/wiki/Taurodontism, PMID:24574680]
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Allelic Composition: Adktm2Bois/Adktm2Bois,Adora1tm1Bbf/Adora1tm1Bbf,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0030524 abnormal tooth root resorption "pathologic resorption in which cementum or dentin is lost from the root of a tooth owing to cementoclastic or osteoclastic activity in conditions such as trauma of occlusion or neoplasms" [MESH:D012391]
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Allelic Composition: Adktm2Bois/Adktm2Bois,Adora1tm1Bbf/Adora1tm1Bbf,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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