ENSMUSG00000067199


Mus musculus

Features
Gene ID: ENSMUSG00000067199
  
Biological name :Frat1
  
Synonyms : Frat1 / P70339 / Proto-onco FRAT1
  
Possible biological names infered from orthology : FRAT1, WNT signaling pathway regulator / Q92837
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: C3
Gene start: 41829970
Gene end: 41832583
  
Corresponding Affymetrix probe sets: 10463164 (MoGene1.0st)   1449814_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000147726
NCBI entrez gene - 14296     See in Manteia.
MGI - MGI:109450
RefSeq - NM_008043
RefSeq Peptide - NP_032069
swissprot - B2RU64
swissprot - P70339
Ensembl - ENSMUSG00000067199
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FRAT1ENSG00000165879Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Peg12 / FRAT1* / Q92837* / FRAT1, WNT signaling pathway regulator*ENSMUSG0000007052680
Frat2 / Q8K025 / GSK-3-binding protein FRAT2 / O75474* / FRAT2, WNT signaling pathway regulator*ENSMUSG0000004760463


Protein motifs (from Interpro)
Interpro ID Name
 IPR008014  Glycogen synthase kinase-3 binding protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000578 embryonic axis specification IDA
 biological_processGO:0006611 protein export from nucleus IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Beta-catenin phosphorylation cascade
Disassembly of the destruction complex and recruitment of AXIN to the membrane


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fgf8tm1Mrc/Fgf8tm2Mrc,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Frat1tm1Brn/Frat1tm1Brn,Frat2tm2Brn/Frat2tm2Brn,Peg12tm1Brn/Peg12tm1Brn
Genetic Background: involves: 129P2/OlaHsd * FVB

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022812 Gsk3b / Q9WV60 / glycogen synthase kinase 3 beta / P49841*  / complex / reaction






 

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