ENSMUSG00000038175


Mus musculus

Features
Gene ID: ENSMUSG00000038175
  
Biological name :Mylip
  
Synonyms : E3 ubiquitin-protein ligase MYLIP / Mylip / Q8BM54
  
Possible biological names infered from orthology : myosin regulatory light chain interacting protein / Q8WY64
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: A5
Gene start: 45389742
Gene end: 45412022
  
Corresponding Affymetrix probe sets: 10404874 (MoGene1.0st)   1424988_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000047403
Ensembl peptide - ENSMUSP00000152597
NCBI entrez gene - 218203     See in Manteia.
MGI - MGI:2388271
RefSeq - NM_153789
RefSeq Peptide - NP_722484
swissprot - Q8BM54
Ensembl - ENSMUSG00000038175
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mylipaENSDARG00000008859Danio rerio
 mylipbENSDARG00000055118Danio rerio
 MYLIPENSGALG00000012704Gallus gallus
 MYLIPENSG00000007944Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Farp2 / Q91VS8 / FERM, ARHGEF and pleckstrin domain-containing protein 2 / O94887* / FERM, ARH/RhoGEF and pleckstrin domain protein 2*ENSMUSG0000003406626
Farp1 / F8VPU2 / FERM, ARHGEF and pleckstrin domain-containing protein 1 / Q9Y4F1* / FERM, ARH/RhoGEF and pleckstrin domain protein 1*ENSMUSG0000002555524
Rdx / P26043 / radixin / P35241*ENSMUSG0000003205022
Msn / P26041 / Moesin / P26038*ENSMUSG0000003120721
Ezr / Ezrin / P26040 / P15311*ENSMUSG0000005239721
Frmd7 / A2AD83 / FERM domain-containing protein 7 / Q6ZUT3* / FERM domain containing 7*ENSMUSG0000003613120
Nf2 / P46662 / Merlin / P35240* / neurofibromin 2*ENSMUSG0000000907319


Protein motifs (from Interpro)
Interpro ID Name
 IPR000299  FERM domain
 IPR000798  Ezrin/radixin/moesin-like
 IPR001841  Zinc finger, RING-type
 IPR011993  PH-like domain superfamily
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR014352  FERM/acyl-CoA-binding protein superfamily
 IPR018979  FERM, N-terminal
 IPR018980  FERM, C-terminal PH-like domain
 IPR019748  FERM central domain
 IPR019749  Band 4.1 domain
 IPR029071  Ubiquitin-like domain superfamily
 IPR035963  FERM superfamily, second domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IDA
 biological_processGO:0007399 nervous system development ISO
 biological_processGO:0010977 negative regulation of neuron projection development IEA
 biological_processGO:0010989 negative regulation of low-density lipoprotein particle clearance IDA
 biological_processGO:0016567 protein ubiquitination ISO
 biological_processGO:0031648 protein destabilization IDA
 biological_processGO:0032803 regulation of low-density lipoprotein particle receptor catabolic process IMP
 biological_processGO:0042632 cholesterol homeostasis IMP
 biological_processGO:0045732 positive regulation of protein catabolic process IDA
 biological_processGO:0071404 cellular response to low-density lipoprotein particle stimulus IC
 cellular_componentGO:0005622 intracellular ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IMP
 molecular_functionGO:0008092 cytoskeletal protein binding ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity ISO


Pathways (from Reactome)
Pathway description
VLDLR internalisation and degradation
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Myh1tm1b(KOMP)Wtsi/Myh1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Myh1tm1b(KOMP)Wtsi/J

 MP:0001415 increased exploration in new environment "greater amount of time spent investigating new location" [J:28825]
Show

Allelic Composition: Myh1tm1b(KOMP)Wtsi/Myh1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Myh1tm1b(KOMP)Wtsi/J

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myh1tm1b(KOMP)Wtsi/Myh1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Myh1tm1b(KOMP)Wtsi/J

 MP:0011396 abnormal sleep behavior "any anomaly in the actions, reactions, or performance of an organism during a periodic, readily reversible state of reduced awareness and metabolic activity" [MGI:smb]
Show

Allelic Composition: Myh1tm1b(KOMP)Wtsi/Myh1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Myh1tm1b(KOMP)Wtsi/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024924 Vldlr / P98156 / very low density lipoprotein receptor / P98155*  / reaction
 ENSMUSG00000038175 Mylip / Q8BM54 / E3 ubiquitin-protein ligase MYLIP / Q8WY64* / myosin regulatory light chain interacting protein*  / complex






 

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