ENSMUSG00000078810


Mus musculus

Features
Gene ID: ENSMUSG00000078810
  
Biological name :Gp6
  
Synonyms : Gp6 / P0C191 / Platelet glycoprotein VI
  
Possible biological names infered from orthology : glycoprotein VI platelet / Q9HCN6
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: A1
Gene start: 4363965
Gene end: 4397744
  
Corresponding Affymetrix probe sets: 1446554_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000104231
Ensembl peptide - ENSMUSP00000145740
NCBI entrez gene - 243816     See in Manteia.
MGI - MGI:1889810
RefSeq - XM_006539910
RefSeq - NM_001163014
RefSeq - XM_006539909
RefSeq Peptide - NP_001156486
swissprot - P0C191
swissprot - A0A140T8Q7
Ensembl - ENSMUSG00000078810
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GP6ENSG00000088053Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ncr1 / natural cytotoxicity triggering receptor 1 / O76036*ENSMUSG0000006252429
Lilra5 / Q6PI73* / LILRB5* / O75022* / O75023* / P59901* / A6NI73* / LILRA4* / LILRA6* / LILRB3* / leukocyte immunoglobulin like receptor A5* / leukocyte immunoglobulin like receptor A6* / ...ENSMUSG0000007087328
Pirb / P97484 / Leukocyte immunoglobulin-like receptor subfamily B member 3 / Q6PI73* / LILRB5* / O75022* / O75023* / P59901* / A6NI73* / LILRA4* / LILRA5* / LILRA6* / LILRB3* / leukocyte ...ENSMUSG0000005881828
Gm14548 / Mus musculus paired-Ig-like receptor A11 (Pira11), mRNA. / Q6PI73* / LILRB5* / O75022* / O75023* / P59901* / A6NI73* / LILRA4* / LILRA5* / LILRA6* / LILRB3* / leukocyte immunoglob...ENSMUSG0000007441727
Pira2 / Q6PI73* / LILRB5* / O75022* / O75023* / P59901* / A6NI73* / LILRA4* / LILRA5* / LILRA6* / LILRB3* / leukocyte immunoglobulin like receptor A5* / leukocyte immunoglobulin like recept...ENSMUSG0000008994227
Gm15922 / predicted gene 15922 / Q6PI73* / LILRB5* / O75022* / O75023* / P59901* / A6NI73* / LILRA4* / LILRA5* / LILRA6* / LILRB3* / leukocyte immunoglobulin like receptor A5* / leukocyte i...ENSMUSG0000008166527
Gm15448 / Q6PI73* / LILRB5* / O75022* / O75023* / P59901* / A6NI73* / LILRA4* / LILRA5* / LILRA6* / LILRB3* / leukocyte immunoglobulin like receptor A4* / leukocyte immunoglobulin like rece...ENSMUSG0000007441927
Lilra6 / leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 / Q6PI73* / LILRB5* / O75022* / O75023* / P59901* / A6NI73* / LILRA4* / LILRA5* / LILRB3* / leukocyte...ENSMUSG0000003042726
Q64281 / Lilrb4 / Leukocyte immunoglobulin-like receptor subfamily B member 4 / Q6PI73* / LILRB5* / O75022* / O75023* / P59901* / A6NI73* / LILRA4* / LILRA5* / LILRA6* / LILRB3* / leukocyt...ENSMUSG0000011214825
Lilr4b / Q61450 / Mast cell surface glycoprotein Gp49A / Q6PI73* / LILRB5* / O75022* / O75023* / P59901* / A6NI73* / LILRA4* / LILRA5* / LILRA6* / LILRB3* / leukocyte immunoglobulin like r...ENSMUSG0000011202325
Q64281 / Lilrb4a / Leukocyte immunoglobulin-like receptor subfamily B member 4 / Q6PI73* / LILRB5* / O75022* / O75023* / P59901* / A6NI73* / LILRA4* / LILRA5* / LILRA6* / LILRB3* / leukocy...ENSMUSG0000006259325
Kir3dl1 / Q99706* / P43626* / P43628* / P43629* / P43630* / KIR3DL2* / KIR2DL1* / KIR2DL3* / KIR2DL4* / KIR2DS4* / KIR3DL3* / killer cell immunoglobulin like receptor, two Ig domains and lo...ENSMUSG0000003142423
Kir3dl2 / Q99706* / P43626* / P43628* / P43629* / P43630* / KIR2DL1* / KIR3DL3* / KIR2DL3* / KIR2DL4* / KIR2DS4* / KIR3DL1* / killer cell immunoglobulin like receptor, two Ig domains and lo...ENSMUSG0000005743923


Protein motifs (from Interpro)
Interpro ID Name
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007596 blood coagulation IEA
 biological_processGO:0007599 hemostasis IEA
 biological_processGO:0038063 collagen-activated tyrosine kinase receptor signaling pathway IMP
 biological_processGO:0038065 collagen-activated signaling pathway IMP
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0097197 tetraspanin-enriched microdomain ISO
 molecular_functionGO:0005518 collagen binding IDA
 molecular_functionGO:0038064 collagen receptor activity IMP


Pathways (from Reactome)
Pathway description
GPVI-mediated activation cascade
Cell surface interactions at the vascular wall
Platelet Adhesion to exposed collagen


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gna11tm1b(EUCOMM)Wtsi/Gna11tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Gna11tm1b(EUCOMM)Wtsi/H

 MP:0001879 abnormal lymphatic vessel morphology "malformation of the network of vessels which carries lymph around the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gp6tm1Beni/Gp6tm1Beni,Clec1btm1.1Arte/Clec1btm1.1Arte,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: 129 * C57BL/6

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gp6tm1Beni/Gp6tm1Beni,Clec1btm1.1Arte/Clec1btm1.1Arte,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: 129 * C57BL/6

 MP:0002098 abnormal vibrissae morphology "irregular or unusual structure, appearance, or alignment of the vibrissae" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gna11tm1b(EUCOMM)Wtsi/Gna11tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Gna11tm1b(EUCOMM)Wtsi/H

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002551 abnormal blood coagulation "altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Gp6tm1Beni/Gp6tm1Beni
Genetic Background: involves: 129 * C57BL/6

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Tg(CAG-Lyn*)#Paau/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gna11tm1b(EUCOMM)Wtsi/Gna11tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Gna11tm1b(EUCOMM)Wtsi/H

 MP:0005464 abnormal platelet physiology "atypical response of the non-nucleated cells found in the blood and involved in blood coagulation" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005606 increased bleeding time "greater than the normal duration of blood flow after skin puncture; indicative of platelet and capillary function" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Gp6tm1Beni/Gp6tm1Beni
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Gp6tm1Beni/Gp6tm1Beni,Clec1btm1.1Arte/Clec1btm1.1Arte,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: 129 * C57BL/6

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Kmt2dtm1.1Kaig/Kmt2dtm1.1Kaig,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0011898 abnormal platelet cell number "anomaly in the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation" [MGI:csmith]
Show

Allelic Composition: Gp6tm1Beni/Gp6tm1Beni,Clec1btm1.1Arte/Clec1btm1.1Arte,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: 129 * C57BL/6

 MP:0011960 abnormal eye anterior chamber depth "anomaly in the distance between the iris and the cornea at the center plane (maximum distance) of the anterior chamber, compared to controls" [MGI:csmith]
Show

Allelic Composition: Gna11tm1b(EUCOMM)Wtsi/Gna11tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Gna11tm1b(EUCOMM)Wtsi/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000058715 Fcer1g / P20491 / High affinity immunoglobulin epsilon receptor subunit gamma / P30273* / Fc fragment of IgE receptor Ig*  / reaction / complex
 ENSMUSG00000042228 Lyn / P25911 / LYN proto-oncogene, Src family tyrosine kinase / P07948*  / complex / reaction
 ENSMUSG00000021457 Syk / P48025 / spleen tyrosine kinase / P43405* / spleen associated tyrosine kinase*  / complex / reaction
 ENSMUSG00000019843 Fyn / P39688 / Tyrosine-protein kinase Fyn / P06241* / FYN proto-oncogene, Src family tyrosine kinase*  / complex / reaction






 

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