ENSMUSG00000062593


Mus musculus

Features
Gene ID: ENSMUSG00000062593
  
Biological name :Lilrb4a
  
Synonyms : Leukocyte immunoglobulin-like receptor subfamily B member 4 / Lilrb4a / Q64281
  
Possible biological names infered from orthology : A6NI73 / leukocyte immunoglobulin like receptor A4 / leukocyte immunoglobulin like receptor A5 / leukocyte immunoglobulin like receptor A6 / leukocyte immunoglobulin like receptor B3 / leukocyte immunoglobulin like receptor B5 / LILRA4 / LILRA5 / LILRA6 / LILRB3 / LILRB5 / O75022 / O75023 / P59901 / Q6PI73
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: B3
Gene start: 51480612
Gene end: 51496613
  
Corresponding Affymetrix probe sets: 10363082 (MoGene1.0st)   1420394_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000151978
Ensembl peptide - ENSMUSP00000151486
Ensembl peptide - ENSMUSP00000151827
MGI - MGI:102701
MGI - MGI:6121530
swissprot - A0A1W2P7X1
swissprot - Q64281
Ensembl - ENSMUSG00000062593
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 A6NI73ENSG00000187116Homo sapiens
 LILRA4ENSG00000239961Homo sapiens
 LILRA6ENSG00000244482Homo sapiens
 LILRB3ENSG00000204577Homo sapiens
 LILRB5ENSG00000105609Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q64281 / Lilrb4 / Leukocyte immunoglobulin-like receptor subfamily B member 4 / Q6PI73* / LILRB5* / O75022* / O75023* / P59901* / A6NI73* / LILRA4* / LILRA5* / LILRA6* / LILRB3* / leukocyt...ENSMUSG00000112148100
Lilr4b / Q61450 / Mast cell surface glycoprotein Gp49A / Q6PI73* / LILRB5* / O75022* / O75023* / P59901* / A6NI73* / LILRA4* / LILRA5* / LILRA6* / LILRB3* / leukocyte immunoglobulin like r...ENSMUSG0000011202381
Pirb / P97484 / Leukocyte immunoglobulin-like receptor subfamily B member 3 / Q6PI73* / LILRB5* / O75022* / O75023* / P59901* / A6NI73* / LILRA4* / LILRA5* / LILRA6* / LILRB3* / leukocyte ...ENSMUSG0000005881843
Pira2 / Q6PI73* / LILRB5* / O75022* / O75023* / P59901* / A6NI73* / LILRA4* / LILRA5* / LILRA6* / LILRB3* / leukocyte immunoglobulin like receptor A5* / leukocyte immunoglobulin like recept...ENSMUSG0000008994232
Gm15922 / predicted gene 15922 / Q6PI73* / LILRB5* / O75022* / O75023* / P59901* / A6NI73* / LILRA4* / LILRA5* / LILRA6* / LILRB3* / leukocyte immunoglobulin like receptor A5* / leukocyte i...ENSMUSG0000008166532
Gm14548 / Mus musculus paired-Ig-like receptor A11 (Pira11), mRNA. / Q6PI73* / LILRB5* / O75022* / O75023* / P59901* / A6NI73* / LILRA4* / LILRA5* / LILRA6* / LILRB3* / leukocyte immunoglob...ENSMUSG0000007441732
Lilra5 / Q6PI73* / LILRB5* / O75022* / O75023* / P59901* / A6NI73* / LILRA4* / LILRA6* / LILRB3* / leukocyte immunoglobulin like receptor A5* / leukocyte immunoglobulin like receptor A6* / ...ENSMUSG0000007087331
Gm15448 / Q6PI73* / LILRB5* / O75022* / O75023* / P59901* / A6NI73* / LILRA4* / LILRA5* / LILRA6* / LILRB3* / leukocyte immunoglobulin like receptor A4* / leukocyte immunoglobulin like rece...ENSMUSG0000007441931
Lilra6 / leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 / Q6PI73* / LILRB5* / O75022* / O75023* / P59901* / A6NI73* / LILRA4* / LILRA5* / LILRB3* / leukocyte...ENSMUSG0000003042730
Ncr1 / natural cytotoxicity triggering receptor 1 / O76036*ENSMUSG0000006252427
Gp6 / P0C191 / Platelet glycoprotein VI / Q9HCN6* / glycoprotein VI platelet*ENSMUSG0000007881024
Kir3dl2 / Q99706* / P43626* / P43628* / P43629* / P43630* / KIR2DL1* / KIR3DL3* / KIR2DL3* / KIR2DL4* / KIR2DS4* / KIR3DL1* / killer cell immunoglobulin like receptor, two Ig domains and lo...ENSMUSG0000005743920
Kir3dl1 / Q99706* / P43626* / P43628* / P43629* / P43630* / KIR3DL2* / KIR2DL1* / KIR2DL3* / KIR2DL4* / KIR2DS4* / KIR3DL3* / killer cell immunoglobulin like receptor, two Ig domains and lo...ENSMUSG0000003142420


Protein motifs (from Interpro)
Interpro ID Name
 IPR007110  Immunoglobulin-like domain
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000716 abnormal immune system cell morphology "anomalous structure, development, or number of immune cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Capgtm1Djk/Capgtm1Djk,Gsntm1Djk/Gsntm1Djk
Genetic Background: involves: 129S4/SvJae

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Capgtm1Djk/Capgtm1Djk,Gsntm1Djk/Gsntm1Djk
Genetic Background: involves: 129S4/SvJae

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Capgtm1Djk/Capgtm1Djk,Gsntm1Djk/Gsntm1Djk
Genetic Background: involves: 129S4/SvJae

 MP:0002133 abnormal respiratory system physiology "anomalous function of the pulmonary system; inability or reduced ability to intake and exchange oxygen and carbon dioxide with the environment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Capgtm1Djk/Capgtm1Djk,Gsntm1Djk/Gsntm1Djk
Genetic Background: involves: 129S4/SvJae

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Capgtm1Djk/Capgtm1Djk,Gsntm1Djk/Gsntm1Djk
Genetic Background: involves: 129S4/SvJae

 MP:0002423 abnormal mast cell physiology "anomalous response of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ndntm1Stw/Ndn+
Genetic Background: involves: 129S1/Sv * FVB

 MP:0002442 abnormal leukocyte physiology "abnormal function of any of the white blood cells (basophils, eosinophils, neutrophils, lymphocytes, or monocytes) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Capgtm1Djk/Capgtm1Djk,Gsntm1Djk/Gsntm1Djk
Genetic Background: involves: 129S4/SvJae

 MP:0002455 abnormal dendritic cell antigen presentation "impairment of these specialized cells to process and present antigen to T lymphoytes" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Scn8amed-TgA4Bs/Scn8amed-TgA4Bs
Genetic Background: B6.Cg-Scn8amed-TgA4Bs

 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Capgtm1Djk/Capgtm1Djk,Gsntm1Djk/Gsntm1Djk
Genetic Background: involves: 129S4/SvJae

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
Show

Allelic Composition: Capgtm1Djk/Capgtm1Djk,Gsntm1Djk/Gsntm1Djk
Genetic Background: involves: 129S4/SvJae

 MP:0005596 increased susceptibility to type I hypersensitvity reaction "greater likelihood of developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ndntm1Stw/Ndn+
Genetic Background: involves: 129S1/Sv * FVB

 MP:0005672 increased susceptibility to graft versus host disease "greater likelihood of developing clinical symptoms of anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the a graft versus host reaction, which is an immunological attack mounted by a graft against the host because of tissue incompatibility when immunologically competent cells are transplanted to an immunologically incompetent host" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:52834]
Show

Allelic Composition: Scn8amed-TgA4Bs/Scn8amed-TgA4Bs
Genetic Background: B6.Cg-Scn8amed-TgA4Bs

 MP:0008097 increased plasma cell number "greater number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Capgtm1Djk/Capgtm1Djk,Gsntm1Djk/Gsntm1Djk
Genetic Background: involves: 129S4/SvJae

 MP:0008713 abnormal cytokine level "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Capgtm1Djk/Capgtm1Djk,Gsntm1Djk/Gsntm1Djk
Genetic Background: involves: 129S4/SvJae

 MP:0008750 abnormal interferon level "deviation from the normal levels of proteins secreted by vertebrate cells in response to a wide variety of inducers; they confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions" [MESH:D12.644.276.374.440]
Show

Allelic Composition: Capgtm1Djk/Capgtm1Djk,Gsntm1Djk/Gsntm1Djk
Genetic Background: involves: 129S4/SvJae

 MP:0008751 abnormal interleukin level "deviation from the normal levels of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
Show

Allelic Composition: Capgtm1Djk/Capgtm1Djk,Gsntm1Djk/Gsntm1Djk
Genetic Background: involves: 129S4/SvJae

 MP:0008764 increased mast cell degranulation "increase in the exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell" [GO:0043303, MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ndntm1Stw/Ndn+
Genetic Background: involves: 129S1/Sv * FVB

Allelic Composition: Lilrb4atm1Eol/Lilrb4atm1Eol
Genetic Background: B6.129P2-Lilrb4atm1Eol

 MP:0009858 abnormal cellular extravasation "any anomaly in the migration of leukocytes from the blood vessels into the surrounding tissue" [GO:0045123]
Show

Allelic Composition: Lilrb4atm1Eol/Lilrb4atm1Eol
Genetic Background: B6.129P2-Lilrb4atm1Eol

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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