ENSMUSG00000062524


Mus musculus

Features
Gene ID: ENSMUSG00000062524
  
Biological name :Ncr1
  
Synonyms : natural cytotoxicity triggering receptor 1 / Ncr1
  
Possible biological names infered from orthology : O76036
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: A1
Gene start: 4337724
Gene end: 4345164
  
Corresponding Affymetrix probe sets: 10549647 (MoGene1.0st)   1422089_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000006792
Ensembl peptide - ENSMUSP00000145847
NCBI entrez gene - 17086     See in Manteia.
MGI - MGI:1336212
RefSeq - NM_010746
RefSeq - XM_006539585
RefSeq Peptide - NP_034876
swissprot - A0A0U1RP63
swissprot - A0A0R4IZY7
Ensembl - ENSMUSG00000062524
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NCR1ENSG00000189430Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pirb / P97484 / Leukocyte immunoglobulin-like receptor subfamily B member 3 / Q6PI73* / LILRB5* / O75022* / O75023* / P59901* / A6NI73* / LILRA4* / LILRA5* / LILRA6* / LILRB3* / leukocyte ...ENSMUSG0000005881830
Gm15448 / Q6PI73* / LILRB5* / O75022* / O75023* / P59901* / A6NI73* / LILRA4* / LILRA5* / LILRA6* / LILRB3* / leukocyte immunoglobulin like receptor A4* / leukocyte immunoglobulin like rece...ENSMUSG0000007441929
Gm14548 / Mus musculus paired-Ig-like receptor A11 (Pira11), mRNA. / Q6PI73* / LILRB5* / O75022* / O75023* / P59901* / A6NI73* / LILRA4* / LILRA5* / LILRA6* / LILRB3* / leukocyte immunoglob...ENSMUSG0000007441729
Pira2 / Q6PI73* / LILRB5* / O75022* / O75023* / P59901* / A6NI73* / LILRA4* / LILRA5* / LILRA6* / LILRB3* / leukocyte immunoglobulin like receptor A5* / leukocyte immunoglobulin like recept...ENSMUSG0000008994229
Q64281 / Lilrb4a / Leukocyte immunoglobulin-like receptor subfamily B member 4 / Q6PI73* / LILRB5* / O75022* / O75023* / P59901* / A6NI73* / LILRA4* / LILRA5* / LILRA6* / LILRB3* / leukocy...ENSMUSG0000006259328
Gp6 / P0C191 / Platelet glycoprotein VI / Q9HCN6* / glycoprotein VI platelet*ENSMUSG0000007881028
Q64281 / Lilrb4 / Leukocyte immunoglobulin-like receptor subfamily B member 4 / Q6PI73* / LILRB5* / O75022* / O75023* / P59901* / A6NI73* / LILRA4* / LILRA5* / LILRA6* / LILRB3* / leukocyt...ENSMUSG0000011214828
Gm15922 / predicted gene 15922 / Q6PI73* / LILRB5* / O75022* / O75023* / P59901* / A6NI73* / LILRA4* / LILRA5* / LILRA6* / LILRB3* / leukocyte immunoglobulin like receptor A5* / leukocyte i...ENSMUSG0000008166528
Lilra5 / Q6PI73* / LILRB5* / O75022* / O75023* / P59901* / A6NI73* / LILRA4* / LILRA6* / LILRB3* / leukocyte immunoglobulin like receptor A5* / leukocyte immunoglobulin like receptor A6* / ...ENSMUSG0000007087326
Lilra6 / leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 / Q6PI73* / LILRB5* / O75022* / O75023* / P59901* / A6NI73* / LILRA4* / LILRA5* / LILRB3* / leukocyte...ENSMUSG0000003042726
Lilr4b / Q61450 / Mast cell surface glycoprotein Gp49A / Q6PI73* / LILRB5* / O75022* / O75023* / P59901* / A6NI73* / LILRA4* / LILRA5* / LILRA6* / LILRB3* / leukocyte immunoglobulin like r...ENSMUSG0000011202326
Kir3dl2 / Q99706* / P43626* / P43628* / P43629* / P43630* / KIR2DL1* / KIR3DL3* / KIR2DL3* / KIR2DL4* / KIR2DS4* / KIR3DL1* / killer cell immunoglobulin like receptor, two Ig domains and lo...ENSMUSG0000005743922
Kir3dl1 / Q99706* / P43626* / P43628* / P43629* / P43630* / KIR3DL2* / KIR2DL1* / KIR2DL3* / KIR2DL4* / KIR2DS4* / KIR3DL3* / killer cell immunoglobulin like receptor, two Ig domains and lo...ENSMUSG0000003142422


Protein motifs (from Interpro)
Interpro ID Name
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013151  Immunoglobulin
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tnni3tm1Jdp/Tnni3tm1Jdp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002410 decreased susceptibility to viral infection "reduced likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Asltm1Brle/Asltm1Brle
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Asltm1Brle/Asltm1Brle
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005070 defective NK cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:6213]
Show

Allelic Composition: Erap1tm1Nsha/Erap1tm1Nsha,Tap1tm1Arp/Tap1tm1Arp
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/10 * DBA/2

 MP:0008044 increased NK cell number "greater number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
Show

Allelic Composition: Asltm1Brle/Asltm1Brle
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008045 decreased NK cell number "reduction in the number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
Show

Allelic Composition: Erap1tm1Nsha/Erap1tm1Nsha,Tap1tm1Arp/Tap1tm1Arp
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/10 * DBA/2

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Asltm1Brle/Asltm1Brle
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Asltm1Brle/Asltm1Brle
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008750 abnormal interferon level "deviation from the normal levels of proteins secreted by vertebrate cells in response to a wide variety of inducers; they confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions" [MESH:D12.644.276.374.440]
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Allelic Composition: ApcMin/Apc+,Spata18tm1.2Hifa/Spata18+
Genetic Background: involves: C57BL/6J

 MP:0009785 altered susceptibility to infection induced morbidity/mortality "differences from the expected moribund state caused by a pathogenic invasion or from components of or toxins produced by pathogens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ApcMin/Apc+,Spata18tm1.2Hifa/Spata18+
Genetic Background: involves: C57BL/6J

 MP:0009790 decreased susceptibility to viral infection induced morbidity/mortality "reduced likelihood that an organism will display the expected moribund state caused by a viral invasion or from components of or toxins produced by a virus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Asltm1Brle/Asltm1Brle
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Ncr1tm1.1(icre)Viv/Ncr1tm1.1(icre)Viv
Genetic Background: involves: C57BL/6

Allelic Composition: Ncr1m1J/Ncr1m1J,Pepcb/Pepcb,Ptprca/Ptprca
Genetic Background: B6.SJL-Ptprca Pepcb/BoyJ

 MP:0009791 increased susceptibility to viral infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a viral invasion or from components of or toxins produced by a virus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Erap1tm1Nsha/Erap1tm1Nsha,Tap1tm1Arp/Tap1tm1Arp
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/10 * DBA/2

Allelic Composition: Ncr1m1J/Ncr1m1J,Pepcb/Pepcb,Ptprca/Ptprca
Genetic Background: B6.SJL-Ptprca Pepcb/BoyJ

 MP:0010766 abnormal NK cell physiology "any functional anomaly of a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells" [GOC:add, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15771571]
Show

Allelic Composition: Asltm1Brle/Asltm1Brle
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Ncr1tm1.1(icre)Viv/Ncr1tm1.1(icre)Viv
Genetic Background: involves: C57BL/6

Allelic Composition: Ncr1m1J/Ncr1m1J,Pepcb/Pepcb,Ptprca/Ptprca
Genetic Background: B6.SJL-Ptprca Pepcb/BoyJ

 MP:0010839 decreased CD8-positive, alpha-beta memory T cell number "decreased number of CD8-positive, alpha-beta T cells with memory phenotype indicated by being CD45RO and CD127-positive, or also described as being CD25-negative, CD44-high, and CD122- high" [CL:0000909, GO_REF:0000031, GOC:tfm, PMID:20146720]
Show

Allelic Composition: Asltm1Brle/Asltm1Brle
Genetic Background: involves: 129S7/SvEvBrd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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