ENSMUSG00000023349


Mus musculus

Features
Gene ID: ENSMUSG00000023349
  
Biological name :Clec4n
  
Synonyms : Clec4n / C-type lectin domain family 6 member A / Q9JKF4
  
Possible biological names infered from orthology : CLEC6A / C-type lectin domain containing 6A / Q6EIG7
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: F2
Gene start: 123229843
Gene end: 123247021
  
Corresponding Affymetrix probe sets: 10541605 (MoGene1.0st)   1419627_s_at (Mouse Genome 430 2.0 Array)   1425951_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000024118
Ensembl peptide - ENSMUSP00000113733
Ensembl peptide - ENSMUSP00000120043
Ensembl peptide - ENSMUSP00000145023
Ensembl peptide - ENSMUSP00000108173
NCBI entrez gene - 56620     See in Manteia.
MGI - MGI:1861231
RefSeq - NM_001190320
RefSeq - NM_001190321
RefSeq - NM_020001
RefSeq Peptide - NP_001177249
RefSeq Peptide - NP_001177250
RefSeq Peptide - NP_064385
swissprot - D6RJL3
swissprot - Q3V2N1
swissprot - A0A0N4SVA9
swissprot - Q9JKF4
swissprot - Q3U3M9
Ensembl - ENSMUSG00000023349
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 illr1ENSDARG00000059254Danio rerio
 illr2ENSDARG00000094882Danio rerio
 illr3ENSDARG00000018327Danio rerio
 illr4ENSDARG00000008075Danio rerio
 si:ch211-133n4.11ENSDARG00000094796Danio rerio
 si:ch211-133n4.12ENSDARG00000092749Danio rerio
 si:ch211-133n4.7ENSDARG00000095424Danio rerio
 si:ch211-232p21.6ENSDARG00000089377Danio rerio
 si:ch73-86n18.1ENSDARG00000056379Danio rerio
 CLEC6AENSG00000205846Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Clec4b1 / C-type lectin domain family 4, member b1 / CLEC4A* / Q9UMR7* / C-type lectin domain family 4 member A*ENSMUSG0000003014758
Clec4b2 / C-type lectin domain family 4, member b2 / CLEC4A* / Q9UMR7* / C-type lectin domain family 4 member A*ENSMUSG0000006776754
Clec4d / Q9Z2H6 / C-type lectin domain family 4 member D / Q8WXI8*ENSMUSG0000003014439
Clec4a3 / C-type lectin domain family 4, member a3 / CLEC4A* / Q9UMR7* / C-type lectin domain family 4 member A*ENSMUSG0000004383239
Clec4a4 / C-type lectin domain family 4, member a4 / CLEC4A* / Q9UMR7* / C-type lectin domain family 4 member A*ENSMUSG0000005963938
Q9QZ15 / Clec4a2 / C-type lectin domain family 4 member A / CLEC4A* / Q9UMR7*ENSMUSG0000003014837
Clec4a1 / C-type lectin domain family 4, member a1 / CLEC4A* / Q9UMR7* / C-type lectin domain family 4 member A*ENSMUSG0000004903736


Protein motifs (from Interpro)
Interpro ID Name
 IPR001304  C-type lectin-like
 IPR016186  C-type lectin-like/link domain superfamily
 IPR016187  C-type lectin fold
 IPR018378  C-type lectin, conserved site
 IPR033989  CD209-like, C-type lectin-like domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0050715 positive regulation of cytokine secretion IDA
 biological_processGO:0050832 defense response to fungus IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030246 carbohydrate binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000519 hydronephrosis "dilation of the pelvis and calices of one or both kidneys" [J:56641]
Show

Allelic Composition: ArTfm/Ar+,EdaTa-25H/Eda+
Genetic Background: involves: 101/H * C3H/HeH

 MP:0001798 impaired macrophage phagocytosis "reduced ability of these phagocytic cells to internalize particulate matter" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Prkralear-3J/Prkralear-3J
Genetic Background: B6.Cg-Prkralear-3J/GrsrJ

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Prkralear-3J/Prkralear-3J
Genetic Background: B6.Cg-Prkralear-3J/GrsrJ

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Prkralear-3J/Prkralear-3J
Genetic Background: B6.Cg-Prkralear-3J/GrsrJ

 MP:0002467 impaired neutrophil phagocytosis "reduced ability of these leukocytes to internalize particulate matter" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Prkralear-3J/Prkralear-3J
Genetic Background: B6.Cg-Prkralear-3J/GrsrJ

 MP:0004194 abnormal kidney pelvis morphology "any structural anomaly of the funnel shaped proximal portion of the ureter that is formed by convergence of the major calices" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: ArTfm/Ar+,EdaTa-25H/Eda+
Genetic Background: involves: 101/H * C3H/HeH

 MP:0005399 increased susceptibility to fungal infection "greater likelihood that an organism will develop ill effects from infection by a yeast or mold, or from components of, or toxins produced by, these organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Prkralear-3J/Prkralear-3J
Genetic Background: B6.Cg-Prkralear-3J/GrsrJ

Allelic Composition: Clec4ntm1Yiw/Clec4ntm1Yiw
Genetic Background: involves: 129P2/OlaHsd

 MP:0008076 abnormal CD4-positive T cell differentiation "atypical production of or inability to produce the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: ArTfm/Ar+,EdaTa-25H/Eda+
Genetic Background: involves: 101/H * C3H/HeH

 MP:0008555 abnormal interferon secretion "anomaly in the production or release of proteins secreted by vertebrate cells in response to a wide variety of inducers; they confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions" [MESH:D12.644.276.374.440]
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Allelic Composition: Prkralear-3J/Prkralear-3J
Genetic Background: B6.Cg-Prkralear-3J/GrsrJ

 MP:0008556 abnormal tumor necrosis factor secretion "anomaly in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Prkralear-3J/Prkralear-3J
Genetic Background: B6.Cg-Prkralear-3J/GrsrJ

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Prkralear-3J/Prkralear-3J
Genetic Background: B6.Cg-Prkralear-3J/GrsrJ

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: ArTfm/Ar+,EdaTa-25H/Eda+
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Clec4ntm1.2Mgne/Clec4ntm1.2Mgne
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Clec4ntm1.2Mgne/Clec4ntm1.2Mgne
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: ArTfm/Ar+,EdaTa-25H/Eda+
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Clec4ntm1.2Mgne/Clec4ntm1.2Mgne
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0008568 abnormal interleukin secretion "anomaly in the production or cellular release of soluble factors which stimulate growth-related activities of leukocytes and other cell types, that can act to enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
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Allelic Composition: Clec4ntm1.2Mgne/Clec4ntm1.2Mgne
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0008654 increased interleukin-1 alpha secretion "increase in the production or release of an interleukin-1 subtype that occurs as a membrane-bound pro-protein form that is cleaved by proteases to form a secreted mature form; both membrane-bound and secreted forms of interleukin-1alpha are biologically active" [MESH:D12.644.276.374.465.501.300]
Show

Allelic Composition: Clec4ntm1.2Mgne/Clec4ntm1.2Mgne
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0008657 increased interleukin-1 beta secretion "increase in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
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Allelic Composition: Clec4ntm1.2Mgne/Clec4ntm1.2Mgne
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0008661 decreased interleukin-10 secretion "reduction in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
Show

Allelic Composition: ArTfm/Ar+,EdaTa-25H/Eda+
Genetic Background: involves: 101/H * C3H/HeH

 MP:0008670 decreased interleukin-12b secretion "reduction in the production or release of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23" [MESH:D12.644.276.374.465.512.500]
Show

Allelic Composition: ArTfm/Ar+,EdaTa-25H/Eda+
Genetic Background: involves: 101/H * C3H/HeH

 MP:0008681 increased interleukin-17 secretion "increase in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
Show

Allelic Composition: Clec4ntm1.2Mgne/Clec4ntm1.2Mgne
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0008682 decreased interleukin-17 secretion "reduction in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
Show

Allelic Composition: ArTfm/Ar+,EdaTa-25H/Eda+
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Clec4ntm1.2Mgne/Clec4ntm1.2Mgne
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0008691 decreased interleukin-23 secretion "reduction in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells" [MESH:D12.644.276.374.465.759]
Show

Allelic Composition: ArTfm/Ar+,EdaTa-25H/Eda+
Genetic Background: involves: 101/H * C3H/HeH

 MP:0008705 increased interleukin-6 secretion "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Clec4ntm1.2Mgne/Clec4ntm1.2Mgne
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: ArTfm/Ar+,EdaTa-25H/Eda+
Genetic Background: involves: 101/H * C3H/HeH

 MP:0008722 abnormal chemokine secretion "anomaly in the production or cellular release of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
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Allelic Composition: Clec4ntm1.2Mgne/Clec4ntm1.2Mgne
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0009787 increased susceptibility to infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a pathogenic invasion or from components of or toxins produced by pathogens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: ArTfm/Ar+,EdaTa-25H/Eda+
Genetic Background: involves: 101/H * C3H/HeH

 MP:0020183 altered susceptibility to fungal infection "a change in the likelihood that an organism will develop ill effects from a fungal infection or from components of or toxins produced by a fungi" [GOC:NV]
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Allelic Composition: Clec4ntm1.2Mgne/Clec4ntm1.2Mgne
Genetic Background: involves: C57BL/6 * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000058715 Fcer1g / P20491 / High affinity immunoglobulin epsilon receptor subunit gamma / P30273* / Fc fragment of IgE receptor Ig*  / complex






 

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