ENSMUSG00000030144


Mus musculus

Features
Gene ID: ENSMUSG00000030144
  
Biological name :Clec4d
  
Synonyms : Clec4d / C-type lectin domain family 4 member D / Q9Z2H6
  
Possible biological names infered from orthology : Q8WXI8
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: F2
Gene start: 123262111
Gene end: 123275265
  
Corresponding Affymetrix probe sets: 10541614 (MoGene1.0st)   1420804_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000032240
Ensembl peptide - ENSMUSP00000145134
NCBI entrez gene - 17474     See in Manteia.
MGI - MGI:1298389
RefSeq - NM_001163161
RefSeq - NM_010819
RefSeq Peptide - NP_001156633
RefSeq Peptide - NP_034949
swissprot - Q9Z2H6
swissprot - Q4KL29
swissprot - A0A0N4SVJ7
Ensembl - ENSMUSG00000030144
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 illr1ENSDARG00000059254Danio rerio
 illr2ENSDARG00000094882Danio rerio
 illr3ENSDARG00000018327Danio rerio
 illr4ENSDARG00000008075Danio rerio
 si:ch211-133n4.11ENSDARG00000094796Danio rerio
 si:ch211-133n4.12ENSDARG00000092749Danio rerio
 si:ch211-133n4.7ENSDARG00000095424Danio rerio
 si:ch211-232p21.6ENSDARG00000089377Danio rerio
 si:ch73-86n18.1ENSDARG00000056379Danio rerio
 CLEC4DENSG00000166527Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Clec4n / Q9JKF4 / C-type lectin domain family 6 member A / Q6EIG7* / CLEC6A* / C-type lectin domain containing 6A*ENSMUSG0000002334937
Clec4b2 / C-type lectin domain family 4, member b2 / CLEC4A* / Q9UMR7* / C-type lectin domain family 4 member A*ENSMUSG0000006776734
Clec4b1 / C-type lectin domain family 4, member b1 / CLEC4A* / Q9UMR7* / C-type lectin domain family 4 member A*ENSMUSG0000003014733
Clec4a4 / C-type lectin domain family 4, member a4 / CLEC4A* / Q9UMR7* / C-type lectin domain family 4 member A*ENSMUSG0000005963931
Clec4a1 / C-type lectin domain family 4, member a1 / CLEC4A* / Q9UMR7* / C-type lectin domain family 4 member A*ENSMUSG0000004903728
Clec4a3 / C-type lectin domain family 4, member a3 / CLEC4A* / Q9UMR7* / C-type lectin domain family 4 member A*ENSMUSG0000004383228
Q9QZ15 / Clec4a2 / C-type lectin domain family 4 member A / CLEC4A* / Q9UMR7*ENSMUSG0000003014826


Protein motifs (from Interpro)
Interpro ID Name
 IPR001304  C-type lectin-like
 IPR016186  C-type lectin-like/link domain superfamily
 IPR016187  C-type lectin fold
 IPR033989  CD209-like, C-type lectin-like domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002250 adaptive immune response IMP
 biological_processGO:0002292 T cell differentiation involved in immune response IMP
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0038094 Fc-gamma receptor signaling pathway IDA
 biological_processGO:0042742 defense response to bacterium IMP
 biological_processGO:0045087 innate immune response IMP
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0030246 carbohydrate binding IEA
 molecular_functionGO:0034987 immunoglobulin receptor binding IPI


Pathways (from Reactome)
Pathway description
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Tg(MMTV-vHaras)SH1Led/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CD-1 * FVB/N

 MP:0000703 abnormal thymus morphology "anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400]
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Allelic Composition: Ank1M1Btlr/Ank1M1Btlr
Genetic Background: C57BL/6J-Ank1m1Btlr

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ank1M1Btlr/Ank1M1Btlr
Genetic Background: C57BL/6J-Ank1m1Btlr

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Clec4dtm1.1Shoy/Clec4dtm1.1Shoy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001835 abnormal antigen presentation "aberration in the process by which peptide is presented to lymphocytes in a form they can recognize " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ank1M1Btlr/Ank1M1Btlr
Genetic Background: C57BL/6J-Ank1m1Btlr

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Tg(MMTV-vHaras)SH1Led/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CD-1 * FVB/N

Allelic Composition: Clec4dtm1.1Shoy/Clec4dtm1.1Shoy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Tg(MMTV-vHaras)SH1Led/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CD-1 * FVB/N

 MP:0002500 granulomatous inflammation "chronic inflammation resulting from the failure of the acute inflammatory response and persistance of the injurious agent; characterized by a central area of marcophages, often fused into giant cells, and surrounded by T cells " [Pathology:ISBN 0-397-51047-0, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ank1M1Btlr/Ank1M1Btlr
Genetic Background: C57BL/6J-Ank1m1Btlr

 MP:0002723 abnormal immune serum protein physiology "abnormal concentration or function of circulating immune proteins" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Clec4dtm1.1Shoy/Clec4dtm1.1Shoy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Clec4dtm1.1Shoy/Clec4dtm1.1Shoy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Tg(MMTV-vHaras)SH1Led/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CD-1 * FVB/N

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Clec4dtm1.1Shoy/Clec4dtm1.1Shoy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Tg(MMTV-vHaras)SH1Led/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CD-1 * FVB/N

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Tg(MMTV-vHaras)SH1Led/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CD-1 * FVB/N

 MP:0005616 decreased susceptibility to type IV hypersensitivity reaction "less likelihood of or resistance to developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Clec4dtm1.1Shoy/Clec4dtm1.1Shoy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008127 decreased dendritic cell number "reduction in the number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Clec4dtm1.1Shoy/Clec4dtm1.1Shoy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008210 increased mature B cell number "greater number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Tg(MMTV-vHaras)SH1Led/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CD-1 * FVB/N

 MP:0008559 abnormal interferon-gamma secretion "anomaly in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Clec4dtm1.1Shoy/Clec4dtm1.1Shoy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Tg(MMTV-vHaras)SH1Led/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CD-1 * FVB/N

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Clec4dtm1.1Shoy/Clec4dtm1.1Shoy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Tg(MMTV-vHaras)SH1Led/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CD-1 * FVB/N

 MP:0008615 decreased circulating interleukin-17 level "reduction in the amount in the blood of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
Show

Allelic Composition: Clec4dtm1.1Shoy/Clec4dtm1.1Shoy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008660 increased interleukin-10 secretion "increase in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
Show

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Tg(MMTV-vHaras)SH1Led/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CD-1 * FVB/N

 MP:0008680 abnormal interleukin-17 secretion "anomaly in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
Show

Allelic Composition: Clec4dtm1.1Shoy/Clec4dtm1.1Shoy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008681 increased interleukin-17 secretion "increase in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
Show

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Tg(MMTV-vHaras)SH1Led/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CD-1 * FVB/N

 MP:0008705 increased interleukin-6 secretion "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Tg(MMTV-vHaras)SH1Led/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CD-1 * FVB/N

 MP:0008722 abnormal chemokine secretion "anomaly in the production or cellular release of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
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Allelic Composition: Clec4dtm1.1Shoy/Clec4dtm1.1Shoy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Clec4dtm1.1Shoy/Clec4dtm1.1Shoy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009767 decreased sensitivity to xenobiotic induced morbidity/mortality "increase in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Clec4dtm1.1Shoy/Clec4dtm1.1Shoy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009788 increased susceptibility to bacterial infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Tg(MMTV-vHaras)SH1Led/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CD-1 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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