ENSMUSG00000030148


Mus musculus

Features
Gene ID: ENSMUSG00000030148
  
Biological name :Clec4a2
  
Synonyms : Clec4a2 / C-type lectin domain family 4 member A / Q9QZ15
  
Possible biological names infered from orthology : CLEC4A / Q9UMR7
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: F2
Gene start: 123106428
Gene end: 123143999
  
Corresponding Affymetrix probe sets: 10541587 (MoGene1.0st)   1422013_at (Mouse Genome 430 2.0 Array)   1425406_at (Mouse Genome 430 2.0 Array)   1425407_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000032248
Ensembl peptide - ENSMUSP00000123973
Ensembl peptide - ENSMUSP00000124532
Ensembl peptide - ENSMUSP00000124615
Ensembl peptide - ENSMUSP00000045781
NCBI entrez gene - 26888     See in Manteia.
MGI - MGI:1349412
RefSeq - XM_011241364
RefSeq - NM_001170332
RefSeq - NM_001170333
RefSeq - NM_011999
RefSeq Peptide - NP_036129
RefSeq Peptide - NP_001163803
RefSeq Peptide - NP_001163804
swissprot - E0CY25
swissprot - E0CYQ6
swissprot - Q923C7
swissprot - Q9QZ15
Ensembl - ENSMUSG00000030148
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 illr1ENSDARG00000059254Danio rerio
 illr2ENSDARG00000094882Danio rerio
 illr3ENSDARG00000018327Danio rerio
 illr4ENSDARG00000008075Danio rerio
 si:ch211-133n4.11ENSDARG00000094796Danio rerio
 si:ch211-133n4.12ENSDARG00000092749Danio rerio
 si:ch211-133n4.7ENSDARG00000095424Danio rerio
 si:ch211-232p21.6ENSDARG00000089377Danio rerio
 si:ch73-86n18.1ENSDARG00000056379Danio rerio
 CLEC4AENSG00000111729Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Clec4a4 / C-type lectin domain family 4, member a4 / CLEC4A* / Q9UMR7* / C-type lectin domain family 4 member A*ENSMUSG0000005963963
Clec4b1 / C-type lectin domain family 4, member b1 / CLEC4A* / Q9UMR7* / C-type lectin domain family 4 member A*ENSMUSG0000003014751
Clec4a3 / C-type lectin domain family 4, member a3 / CLEC4A* / Q9UMR7* / C-type lectin domain family 4 member A*ENSMUSG0000004383249
Clec4a1 / C-type lectin domain family 4, member a1 / CLEC4A* / Q9UMR7* / C-type lectin domain family 4 member A*ENSMUSG0000004903744
Clec4b2 / C-type lectin domain family 4, member b2 / CLEC4A* / Q9UMR7* / C-type lectin domain family 4 member A*ENSMUSG0000006776737
Clec4n / Q9JKF4 / C-type lectin domain family 6 member A / Q6EIG7* / CLEC6A* / C-type lectin domain containing 6A*ENSMUSG0000002334930
Clec4d / Q9Z2H6 / C-type lectin domain family 4 member D / Q8WXI8*ENSMUSG0000003014422


Protein motifs (from Interpro)
Interpro ID Name
 IPR001304  C-type lectin-like
 IPR016186  C-type lectin-like/link domain superfamily
 IPR016187  C-type lectin fold
 IPR018378  C-type lectin, conserved site
 IPR033989  CD209-like, C-type lectin-like domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0045087 innate immune response IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0030246 carbohydrate binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000685 abnormal immune system morphology "morphological anomalies in the organs or cells associated with the development and formation of lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Scml2em2Shnk/Scml2em2Shnk
Genetic Background: C57BL/6J-Scml2em2Shnk

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Pou5f1-cre/ERT2)#Ysa/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0001154 seminiferous tubule degeneration "a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs" [J:50844]
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Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Pou5f1-cre/ERT2)#Ysa/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Scml2em2Shnk/Scml2em2Shnk
Genetic Background: C57BL/6J-Scml2em2Shnk

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Pou5f1-cre/ERT2)#Ysa/0
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Clec4a2tm1Yiw/Clec4a2tm1Yiw
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001870 salivary gland inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the salivary gland" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Clec4a2tm1Yiw/Clec4a2tm1Yiw
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002493 increased IgG "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Clec4a2tm1Yiw/Clec4a2tm1Yiw
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002933 joint inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the joints" [RGD:Rat Genome Database submission]
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Allelic Composition: Clec4a2tm1Yiw/Clec4a2tm1Yiw
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003724 susceptibility to induced arthritis "more likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Clec4a2tm1Yiw/Clec4a2tm1Yiw
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003725 increased autoantibody level "elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Clec4a2tm1Yiw/Clec4a2tm1Yiw
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004794 increased anti-nuclear antigen antibody level "elevated level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Clec4a2tm1Yiw/Clec4a2tm1Yiw
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005154 increased B cell proliferation "greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Pou5f1-cre/ERT2)#Ysa/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0006431 abnormal fibrocartilage morphology "any structural anomaly of the nonvascular, resilient, flexible connective tissue containing thick bundles of collagenous fibers; found primarily in intervertebral disks" [ISBN:0-8036-0655-9 "Taber s Cyclopedic Medical Dictionary", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Clec4a2tm1Yiw/Clec4a2tm1Yiw
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008082 increased single-positive T cell number "greater number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Clec4a2tm1Yiw/Clec4a2tm1Yiw
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008126 increased dendritic cell number "greater number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Clec4a2tm1Yiw/Clec4a2tm1Yiw
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Clec4a2tm1Yiw/Clec4a2tm1Yiw
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Pou5f1-cre/ERT2)#Ysa/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0008501 increased IgG2b level "greater than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Pou5f1-cre/ERT2)#Ysa/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0008502 increased IgG3 level "greater than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Pou5f1-cre/ERT2)#Ysa/0
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Clec4a2tm1Yiw/Clec4a2tm1Yiw
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008588 abnormal circulating interleukin level "anomaly in the amount in the blood of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
Show

Allelic Composition: Clec4a2tm1Yiw/Clec4a2tm1Yiw
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008593 increased circulating interleukin-10 level "increase in the amount in the blood of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
Show

Allelic Composition: Clec4a2tm1Yiw/Clec4a2tm1Yiw
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008602 increased circulating interleukin-4 level "increase in the amount in the blood of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
Show

Allelic Composition: Clec4a2tm1Yiw/Clec4a2tm1Yiw
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008614 increased circulating interleukin-17 level "increase in the amount in the blood of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
Show

Allelic Composition: Clec4a2tm1Yiw/Clec4a2tm1Yiw
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008620 increased circulating interleukin-23 level "increase in the amount in the blood of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells" [MESH:D12.644.276.374.465.759]
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Allelic Composition: Clec4a2tm1Yiw/Clec4a2tm1Yiw
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0013942 enthesitis "inflammation of the entheses, the sites where tendons or ligaments insert into the bone; the entheses are any point of attachment of skeletal muscles to the bone, where recurring stress or inflammatory autoimmune disease can cause inflammation or occasionally fibrosis and calcification" [https://en.wikipedia.org/wiki/Enthesitis]
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Allelic Composition: Clec4a2tm1Yiw/Clec4a2tm1Yiw
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0020039 increased bone ossification "increase in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: Clec4a2tm1Yiw/Clec4a2tm1Yiw
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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