ENSG00000091181


Homo sapiens

Features
Gene ID: ENSG00000091181
  
Biological name :IL5RA
  
Synonyms : IL5RA / interleukin 5 receptor subunit alpha / Q01344
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: p26.2
Gene start: 3066326
Gene end: 3126613
  
Corresponding Affymetrix probe sets: 207902_at (Human Genome U133 Plus 2.0 Array)   210744_s_at (Human Genome U133 Plus 2.0 Array)   211516_at (Human Genome U133 Plus 2.0 Array)   211517_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000391274
Ensembl peptide - ENSP00000390753
Ensembl peptide - ENSP00000392059
Ensembl peptide - ENSP00000412209
Ensembl peptide - ENSP00000400400
Ensembl peptide - ENSP00000398117
Ensembl peptide - ENSP00000256452
Ensembl peptide - ENSP00000309196
Ensembl peptide - ENSP00000373358
Ensembl peptide - ENSP00000388858
NCBI entrez gene - 3568     See in Manteia.
OMIM - 147851
RefSeq - XM_011533678
RefSeq - NM_000564
RefSeq - NM_001243099
RefSeq - NM_175724
RefSeq - NM_175725
RefSeq - NM_175726
RefSeq - NM_175727
RefSeq - NM_175728
RefSeq - XM_011533677
RefSeq Peptide - NP_783851
RefSeq Peptide - NP_783852
RefSeq Peptide - NP_783853
RefSeq Peptide - NP_783854
RefSeq Peptide - NP_783855
RefSeq Peptide - NP_001230028
RefSeq Peptide - NP_000555
swissprot - C9J3K8
swissprot - A0A024R2C8
swissprot - E7ERY4
swissprot - C9J6C4
swissprot - Q01344
Ensembl - ENSG00000091181
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 il13ra2ENSDARG00000039436Danio rerio
 IL5RAENSGALG00000008267Gallus gallus
 Il5raENSMUSG00000005364Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q14627 / IL13RA2 / interleukin 13 receptor subunit alpha 2ENSG0000012349622
P78552 / IL13RA1 / interleukin 13 receptor subunit alpha 1ENSG0000013172419


Protein motifs (from Interpro)
Interpro ID Name
 IPR003532  Short hematopoietin receptor, family 2, conserved site
 IPR003961  Fibronectin type III
 IPR013783  Immunoglobulin-like fold
 IPR015321  Type I cytokine receptor, cytokine-binding domain
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0002437 inflammatory response to antigenic stimulus IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 biological_processGO:0032674 regulation of interleukin-5 production IEA
 biological_processGO:0038043 interleukin-5-mediated signaling pathway IEA
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0071310 cellular response to organic substance IEA
 cellular_componentGO:0005615 extracellular space TAS
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity TAS
 molecular_functionGO:0004896 cytokine receptor activity IEA
 molecular_functionGO:0004914 interleukin-5 receptor activity TAS
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Interleukin-3, Interleukin-5 and GM-CSF signaling
RAF/MAP kinase cascade
Interleukin receptor SHC signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000113525 IL5 / P05113 / interleukin 5  / complex / reaction
 ENSG00000171608 O00329 / PIK3CD / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta  / complex / reaction
 ENSG00000145675 P27986 / PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1  / reaction / complex
 ENSG00000121879 P42336 / PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha  / complex / reaction
 ENSG00000173757 P51692 / STAT5B / signal transducer and activator of transcription 5B  / reaction / complex
 ENSG00000051382 P42338 / PIK3CB / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta  / complex / reaction
 ENSG00000126561 P42229 / STAT5A / signal transducer and activator of transcription 5A  / complex / reaction
 ENSG00000091181 IL5RA / Q01344 / interleukin 5 receptor subunit alpha  / complex
 ENSG00000179295 PTPN11 / Q06124 / protein tyrosine phosphatase, non-receptor type 11  / complex / reaction
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / complex / reaction
 ENSG00000111679 PTPN6 / P29350 / protein tyrosine phosphatase, non-receptor type 6  / complex / reaction
 ENSG00000033327 GAB2 / Q9UQC2 / GRB2 associated binding protein 2  / complex
 ENSG00000100368 CSF2RB / P32927 / colony stimulating factor 2 receptor beta common subunit  / reaction / complex
 ENSG00000072062 P17612 / PRKACA / protein kinase cAMP-activated catalytic subunit alpha  / reaction
 ENSG00000165458 INPPL1 / O15357 / inositol polyphosphate phosphatase like 1  / reaction / complex
 ENSG00000164924 YWHAZ / P63104 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta  / reaction / complex
 ENSG00000168918 INPP5D / Q92835 / inositol polyphosphate-5-phosphatase D  / complex / reaction
 ENSG00000160691 SHC1 / P29353 / SHC adaptor protein 1  / reaction / complex
 ENSG00000096968 JAK2 / O60674 / Janus kinase 2  / reaction / complex
 ENSG00000115904 SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1  / complex / reaction






 

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