ENSG00000168918


Homo sapiens

Features
Gene ID: ENSG00000168918
  
Biological name :INPP5D
  
Synonyms : inositol polyphosphate-5-phosphatase D / INPP5D / Q92835
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q37.1
Gene start: 233059967
Gene end: 233207903
  
Corresponding Affymetrix probe sets: 1568943_at (Human Genome U133 Plus 2.0 Array)   203331_s_at (Human Genome U133 Plus 2.0 Array)   203332_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000397421
Ensembl peptide - ENSP00000414835
Ensembl peptide - ENSP00000473280
Ensembl peptide - ENSP00000352575
Ensembl peptide - ENSP00000405338
NCBI entrez gene - 3635     See in Manteia.
OMIM - 601582
RefSeq - XM_017004004
RefSeq - NM_001017915
RefSeq - NM_005541
RefSeq Peptide - NP_001017915
RefSeq Peptide - NP_005532
swissprot - H0Y5Q9
swissprot - Q92835
swissprot - H7C403
swissprot - R4GMN8
Ensembl - ENSG00000168918
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 inpp5dENSDARG00000074283Danio rerio
 INPP5DENSGALG00000035498Gallus gallus
 Inpp5dENSMUSG00000026288Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
INPPL1 / O15357 / inositol polyphosphate phosphatase like 1ENSG0000016545840
SYNJ1 / O43426 / synaptojanin 1ENSG0000015908218
SYNJ2 / O15056 / synaptojanin 2ENSG0000007826917
OCRL / Q01968 / OCRL, inositol polyphosphate-5-phosphataseENSG0000012212613
INPP5B / P32019 / inositol polyphosphate-5-phosphatase BENSG0000020408413
INPP5J / Q15735 / inositol polyphosphate-5-phosphatase JENSG0000018513312
INPP5E / Q9NRR6 / inositol polyphosphate-5-phosphatase EENSG0000014838411
INPP5K / Q9BT40 / inositol polyphosphate-5-phosphatase KENSG000001323768
Q96GF1 / RNF185 / ring finger protein 185ENSG000001389423


Protein motifs (from Interpro)
Interpro ID Name
 IPR000300  Inositol polyphosphate-related phosphatase
 IPR000980  SH2 domain
 IPR005135  Endonuclease/exonuclease/phosphatase
 IPR036691  Endonuclease/exonuclease/phosphatase superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006661 phosphatidylinositol biosynthetic process TAS
 biological_processGO:0006796 phosphate-containing compound metabolic process TAS
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0008340 determination of adult lifespan IEA
 biological_processGO:0009968 negative regulation of signal transduction IEA
 biological_processGO:0016064 immunoglobulin mediated immune response IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0030853 negative regulation of granulocyte differentiation IEA
 biological_processGO:0030889 negative regulation of B cell proliferation IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043647 inositol phosphate metabolic process TAS
 biological_processGO:0045409 negative regulation of interleukin-6 biosynthetic process IEA
 biological_processGO:0045579 positive regulation of B cell differentiation IEA
 biological_processGO:0045621 positive regulation of lymphocyte differentiation IEA
 biological_processGO:0045648 positive regulation of erythrocyte differentiation IEA
 biological_processGO:0045656 negative regulation of monocyte differentiation IEA
 biological_processGO:0045659 negative regulation of neutrophil differentiation IEA
 biological_processGO:0045671 negative regulation of osteoclast differentiation IEA
 biological_processGO:0045779 negative regulation of bone resorption IEA
 biological_processGO:0046856 phosphatidylinositol dephosphorylation IEA
 biological_processGO:0050777 negative regulation of immune response IEA
 biological_processGO:0050852 T cell receptor signaling pathway TAS
 biological_processGO:0050869 negative regulation of B cell activation IEA
 biological_processGO:0050900 leukocyte migration TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0045121 membrane raft IEA
 molecular_functionGO:0004445 inositol-polyphosphate 5-phosphatase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity TAS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0017124 SH3 domain binding IEA
 molecular_functionGO:0034485 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity TAS
 molecular_functionGO:0034594 phosphatidylinositol trisphosphate phosphatase activity IEA
 molecular_functionGO:0051425 PTB domain binding IEA
 molecular_functionGO:0052659 inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity TAS


Pathways (from Reactome)
Pathway description
Synthesis of PIPs at the plasma membrane
Synthesis of IP3 and IP4 in the cytosol
Downstream TCR signaling
PECAM1 interactions
Interleukin receptor SHC signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000165458 INPPL1 / O15357 / inositol polyphosphate phosphatase like 1  / reaction / complex
 ENSG00000164400 CSF2 / P04141 / colony stimulating factor 2  / complex / reaction
 ENSG00000185291 IL3RA / P26951 / interleukin 3 receptor subunit alpha  / complex / reaction
 ENSG00000164399 IL3 / P08700 / interleukin 3  / complex / reaction
 ENSG00000100368 CSF2RB / P32927 / colony stimulating factor 2 receptor beta common subunit  / complex / reaction
 ENSG00000091181 IL5RA / Q01344 / interleukin 5 receptor subunit alpha  / reaction / complex
 ENSG00000160691 SHC1 / P29353 / SHC adaptor protein 1  / complex / reaction
 ENSG00000168918 INPP5D / Q92835 / inositol polyphosphate-5-phosphatase D  / complex / reaction
 ENSG00000096968 JAK2 / O60674 / Janus kinase 2  / complex / reaction
 ENSG00000113525 IL5 / P05113 / interleukin 5  / complex / reaction
 ENSG00000198223 CSF2RA / P15509 / colony stimulating factor 2 receptor alpha subunit  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr