ENSGALG00000035498


Gallus gallus

Features
Gene ID: ENSGALG00000035498
  
Biological name :INPP5D
  
Synonyms : inositol polyphosphate-5-phosphatase D / INPP5D
  
Possible biological names infered from orthology : Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 / Q92835 / Q9ES52
  
Species: Gallus gallus
  
Chr. number: 9
Strand: 1
Band:
Gene start: 1130716
Gene end: 1154017
  
Corresponding Affymetrix probe sets: GgaAffx.1032.1.S1_s_at (Chicken Array)   GgaAffx.1032.3.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000050964
NCBI entrez gene - 424745     See in Manteia.
RefSeq - XM_015276958
swissprot - A0A1D5PDW6
Ensembl - ENSGALG00000035498
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 inpp5dENSDARG00000074283Danio rerio
 INPP5DENSG00000168918Homo sapiens
 Inpp5dENSMUSG00000026288Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
INPPL1 / inositol polyphosphate phosphatase like 1 / O15357* / Q6P549* / Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 *ENSGALG0000000433633
SYNJ2 / synaptojanin 2 / O15056* / Q9D2G5*ENSGALG0000001372716
SYNJ1 / synaptojanin 1 / O43426*ENSGALG0000003431714
OCRL / OCRL, inositol polyphosphate-5-phosphatase / Q01968* / Q6NVF0* / Inositol polyphosphate 5-phosphatase OCRL-1 *ENSGALG0000000392013
INPP5B / inositol polyphosphate-5-phosphatase B / P32019* / Q8K337* / Type II inositol 1,4,5-trisphosphate 5-phosphatase *ENSGALG0000000160611
INPP5E / inositol polyphosphate-5-phosphatase E / Q9JII1* / Q9NRR6* / 72 kDa inositol polyphosphate 5-phosphatase *ENSGALG0000000196410
INPP5J / inositol polyphosphate-5-phosphatase J / P59644* / Q15735* / Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A *ENSGALG000000232669
INPP5K / inositol polyphosphate 5-phosphatase K / Q8C5L6* / Q9BT40*ENSGALG000000027398


Protein motifs (from Interpro)
Interpro ID Name
 IPR000300  Inositol polyphosphate-related phosphatase
 IPR000980  SH2 domain
 IPR005135  Endonuclease/exonuclease/phosphatase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0008340 determination of adult lifespan IEA
 biological_processGO:0009968 negative regulation of signal transduction IEA
 biological_processGO:0016064 immunoglobulin mediated immune response IEA
 biological_processGO:0030853 negative regulation of granulocyte differentiation IEA
 biological_processGO:0030889 negative regulation of B cell proliferation IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0045409 negative regulation of interleukin-6 biosynthetic process IEA
 biological_processGO:0045579 positive regulation of B cell differentiation IEA
 biological_processGO:0045621 positive regulation of lymphocyte differentiation IEA
 biological_processGO:0045648 positive regulation of erythrocyte differentiation IEA
 biological_processGO:0045656 negative regulation of monocyte differentiation IEA
 biological_processGO:0045659 negative regulation of neutrophil differentiation IEA
 biological_processGO:0045671 negative regulation of osteoclast differentiation IEA
 biological_processGO:0045779 negative regulation of bone resorption IEA
 biological_processGO:0046856 phosphatidylinositol dephosphorylation IEA
 biological_processGO:0050777 negative regulation of immune response IEA
 biological_processGO:0050869 negative regulation of B cell activation IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0004445 inositol-polyphosphate 5-phosphatase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0017124 SH3 domain binding IEA
 molecular_functionGO:0034594 phosphatidylinositol trisphosphate phosphatase activity IEA
 molecular_functionGO:0051425 PTB domain binding IEA


Pathways (from Reactome)
Pathway description
Synthesis of PIPs at the plasma membrane
Synthesis of IP3 and IP4 in the cytosol
Downstream TCR signaling
Interleukin receptor SHC signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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