ENSGALG00000004336


Gallus gallus

Features
Gene ID: ENSGALG00000004336
  
Biological name :INPPL1
  
Synonyms : inositol polyphosphate phosphatase like 1 / INPPL1
  
Possible biological names infered from orthology : O15357 / Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 / Q6P549
  
Species: Gallus gallus
  
Chr. number: 4
Strand: -1
Band:
Gene start: 1242567
Gene end: 1251009
  
Corresponding Affymetrix probe sets: GgaAffx.2633.1.S1_at (Chicken Array)   GgaAffx.2701.1.S1_at (Chicken Array)   GgaAffx.994.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000006906
NCBI entrez gene - 428692     See in Manteia.
RefSeq - XM_015278346
swissprot - F1NW40
Ensembl - ENSGALG00000004336
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 inppl1bENSDARG00000001442Danio rerio
 INPPL1ENSG00000165458Homo sapiens
 Inppl1ENSMUSG00000032737Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
INPP5D / inositol polyphosphate-5-phosphatase D / Q92835* / Q9ES52* / Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 *ENSGALG0000003549834
SYNJ2 / synaptojanin 2 / O15056* / Q9D2G5*ENSGALG0000001372714
SYNJ1 / synaptojanin 1 / O43426*ENSGALG0000003431714
INPP5B / inositol polyphosphate-5-phosphatase B / P32019* / Q8K337* / Type II inositol 1,4,5-trisphosphate 5-phosphatase *ENSGALG0000000160613
OCRL / OCRL, inositol polyphosphate-5-phosphatase / Q01968* / Q6NVF0* / Inositol polyphosphate 5-phosphatase OCRL-1 *ENSGALG0000000392013
INPP5E / inositol polyphosphate-5-phosphatase E / Q9JII1* / Q9NRR6* / 72 kDa inositol polyphosphate 5-phosphatase *ENSGALG0000000196410
INPP5K / inositol polyphosphate 5-phosphatase K / Q8C5L6* / Q9BT40*ENSGALG000000027399
INPP5J / inositol polyphosphate-5-phosphatase J / P59644* / Q15735* / Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A *ENSGALG000000232669


Protein motifs (from Interpro)
Interpro ID Name
 IPR000300  Inositol polyphosphate-related phosphatase
 IPR000980  SH2 domain
 IPR005135  Endonuclease/exonuclease/phosphatase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001958 endochondral ossification IEA
 biological_processGO:0006006 glucose metabolic process IEA
 biological_processGO:0006661 phosphatidylinositol biosynthetic process IEA
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0007015 actin filament organization IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0009791 post-embryonic development IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0032868 response to insulin IEA
 biological_processGO:0044255 cellular lipid metabolic process IEA
 biological_processGO:0046856 phosphatidylinositol dephosphorylation IEA
 biological_processGO:0097178 ruffle assembly IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042169 SH2 domain binding IEA


Pathways (from Reactome)
Pathway description
Synthesis of PIPs at the plasma membrane
Synthesis of IP3 and IP4 in the cytosol
Interleukin receptor SHC signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000004336 INPPL1 / inositol polyphosphate phosphatase like 1 / O15357* / Q6P549* / Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 *  / complex / reaction
 ENSGALG00000019147 IL3RA* / P26951* / P26952* / P15509* / Q00941* / CSF2RA* / interleukin 3 receptor subunit alpha* / colony stimulating factor 2 receptor alpha subunit* / Granulocyte-macrophage colony-stimul...  / reaction / complex
 ENSGALG00000015027 JAK2 / Janus kinase 2 / O60674*  / complex / reaction
 ENSGALG00000016693 CSF2RA / IL3RA* / P15509* / Q00941* / P26951* / P26952* / interleukin 3 receptor subunit alpha* / colony stimulating factor 2 receptor alpha subunit* / Granulocyte-macrophage colony-stimula...  / complex / reaction
 ENSGALG00000008267 IL5RA / interleukin 5 receptor subunit alpha / P21183* / Q01344*  / reaction / complex
 ENSGALG00000039775 SHC1 / SHC adaptor protein 1 / P29353* / P98083* / SHC-transforming protein 1 *  / complex / reaction






 

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