ENSG00000185133


Homo sapiens

Features
Gene ID: ENSG00000185133
  
Biological name :INPP5J
  
Synonyms : inositol polyphosphate-5-phosphatase J / INPP5J / Q15735
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 22
Strand: 1
Band: q12.2
Gene start: 31122731
Gene end: 31134696
  
Corresponding Affymetrix probe sets: 213651_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000384540
Ensembl peptide - ENSP00000479645
Ensembl peptide - ENSP00000406570
Ensembl peptide - ENSP00000401124
Ensembl peptide - ENSP00000392924
Ensembl peptide - ENSP00000385343
Ensembl peptide - ENSP00000385264
Ensembl peptide - ENSP00000384596
Ensembl peptide - ENSP00000333262
Ensembl peptide - ENSP00000383150
Ensembl peptide - ENSP00000384534
NCBI entrez gene - 27124     See in Manteia.
OMIM - 606481
RefSeq - XM_017028773
RefSeq - NM_001002837
RefSeq - NM_001284285
RefSeq - NM_001284286
RefSeq - NM_001284287
RefSeq - NM_001284288
RefSeq - NM_001284289
RefSeq - XM_011530143
RefSeq - XM_017028771
RefSeq - XM_017028772
RefSeq Peptide - NP_001271214
RefSeq Peptide - NP_001002837
RefSeq Peptide - NP_001271215
RefSeq Peptide - NP_001271216
RefSeq Peptide - NP_001271217
RefSeq Peptide - NP_001271218
swissprot - C9J0H5
swissprot - B4DF95
swissprot - C9K0M5
swissprot - B5MCL8
swissprot - B5MBZ3
swissprot - Q15735
swissprot - A0A087WVS7
Ensembl - ENSG00000185133
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 inpp5jaENSDARG00000078542Danio rerio
 inpp5jbENSDARG00000093359Danio rerio
 INPP5JENSGALG00000023266Gallus gallus
 Inpp5jENSMUSG00000034570Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SYNJ1 / O43426 / synaptojanin 1ENSG0000015908221
INPP5K / Q9BT40 / inositol polyphosphate-5-phosphatase KENSG0000013237620
SYNJ2 / O15056 / synaptojanin 2ENSG0000007826919
INPP5B / P32019 / inositol polyphosphate-5-phosphatase BENSG0000020408417
OCRL / Q01968 / OCRL, inositol polyphosphate-5-phosphataseENSG0000012212617
INPP5D / Q92835 / inositol polyphosphate-5-phosphatase DENSG0000016891815
INPPL1 / O15357 / inositol polyphosphate phosphatase like 1ENSG0000016545813
INPP5E / Q9NRR6 / inositol polyphosphate-5-phosphatase EENSG0000014838412
Q96GF1 / RNF185 / ring finger protein 185ENSG000001389423


Protein motifs (from Interpro)
Interpro ID Name
 IPR000300  Inositol polyphosphate-related phosphatase
 IPR005135  Endonuclease/exonuclease/phosphatase
 IPR036691  Endonuclease/exonuclease/phosphatase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006661 phosphatidylinositol biosynthetic process TAS
 biological_processGO:0010977 negative regulation of neuron projection development IEA
 biological_processGO:0031115 negative regulation of microtubule polymerization IEA
 biological_processGO:0033137 negative regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0043647 inositol phosphate metabolic process TAS
 biological_processGO:0046856 phosphatidylinositol dephosphorylation IEA
 cellular_componentGO:0001726 ruffle IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0043198 dendritic shaft IEA
 molecular_functionGO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity TAS
 molecular_functionGO:0004445 inositol-polyphosphate 5-phosphatase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0017124 SH3 domain binding IEA
 molecular_functionGO:0034485 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity TAS
 molecular_functionGO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity IEA
 molecular_functionGO:0052659 inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of PIPs at the plasma membrane
Synthesis of IP2, IP, and Ins in the cytosol
Synthesis of IP3 and IP4 in the cytosol


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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