ENSG00000078269


Homo sapiens

Features
Gene ID: ENSG00000078269
  
Biological name :SYNJ2
  
Synonyms : O15056 / synaptojanin 2 / SYNJ2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: q25.3
Gene start: 157981887
Gene end: 158099176
  
Corresponding Affymetrix probe sets: 1555009_a_at (Human Genome U133 Plus 2.0 Array)   210612_s_at (Human Genome U133 Plus 2.0 Array)   212828_at (Human Genome U133 Plus 2.0 Array)   216180_s_at (Human Genome U133 Plus 2.0 Array)   216181_at (Human Genome U133 Plus 2.0 Array)   216182_at (Human Genome U133 Plus 2.0 Array)   240257_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000436657
Ensembl peptide - ENSP00000411202
Ensembl peptide - ENSP00000492369
Ensembl peptide - ENSP00000492532
Ensembl peptide - ENSP00000347792
Ensembl peptide - ENSP00000356080
Ensembl peptide - ENSP00000356089
NCBI entrez gene - 8871     See in Manteia.
OMIM - 609410
RefSeq - XM_017011406
RefSeq - XM_005267200
RefSeq - XM_006715592
RefSeq - XM_011536224
RefSeq - XM_011536225
RefSeq - XM_011536226
RefSeq - XM_011536227
RefSeq - XM_011536228
RefSeq - XM_011536230
RefSeq - NM_001178088
RefSeq - NM_003898
RefSeq - XM_005267198
RefSeq - XM_005267199
RefSeq Peptide - NP_003889
RefSeq Peptide - NP_001171559
swissprot - H7BY56
swissprot - Q5TA15
swissprot - A0A1W2PR85
swissprot - E7ER60
swissprot - O15056
swissprot - H0YEV8
Ensembl - ENSG00000078269
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SYNJ2ENSGALG00000013727Gallus gallus
 Synj2ENSMUSG00000023805Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SYNJ1 / O43426 / synaptojanin 1ENSG0000015908243
OCRL / Q01968 / OCRL, inositol polyphosphate-5-phosphataseENSG0000012212614
INPP5D / Q92835 / inositol polyphosphate-5-phosphatase DENSG0000016891814
INPP5B / P32019 / inositol polyphosphate-5-phosphatase BENSG0000020408414
INPP5J / Q15735 / inositol polyphosphate-5-phosphatase JENSG0000018513313
INPPL1 / O15357 / inositol polyphosphate phosphatase like 1ENSG0000016545813
INPP5E / Q9NRR6 / inositol polyphosphate-5-phosphatase EENSG0000014838410
INPP5K / Q9BT40 / inositol polyphosphate-5-phosphatase KENSG000001323767
Q96GF1 / RNF185 / ring finger protein 185ENSG000001389423


Protein motifs (from Interpro)
Interpro ID Name
 IPR000300  Inositol polyphosphate-related phosphatase
 IPR000504  RNA recognition motif domain
 IPR002013  SAC domain
 IPR005135  Endonuclease/exonuclease/phosphatase
 IPR015047  Domain of unknown function DUF1866
 IPR034973  Synaptojanin-2, RNA recognition motif
 IPR034974  Synaptojanin-2
 IPR035979  RNA-binding domain superfamily
 IPR036691  Endonuclease/exonuclease/phosphatase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006661 phosphatidylinositol biosynthetic process TAS
 biological_processGO:0036092 phosphatidylinositol-3-phosphate biosynthetic process IEA
 biological_processGO:0046856 phosphatidylinositol dephosphorylation IEA
 biological_processGO:0061024 membrane organization TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0045121 membrane raft IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0004438 phosphatidylinositol-3-phosphatase activity TAS
 molecular_functionGO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0034595 phosphatidylinositol phosphate 5-phosphatase activity IEA
 molecular_functionGO:0034596 phosphatidylinositol phosphate 4-phosphatase activity TAS
 molecular_functionGO:0042578 phosphoric ester hydrolase activity IEA
 molecular_functionGO:0043813 phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity TAS
 molecular_functionGO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity TAS


Pathways (from Reactome)
Pathway description
Synthesis of PIPs at the plasma membrane
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000079805 DNM2 / P50570 / dynamin 2  / complex / reaction






 

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