ENSMUSG00000023805


Mus musculus

Features
Gene ID: ENSMUSG00000023805
  
Biological name :Synj2
  
Synonyms : Q9D2G5 / Synaptojanin-2 / Synj2
  
Possible biological names infered from orthology : O15056
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: A1
Gene start: 5941280
Gene end: 6044290
  
Corresponding Affymetrix probe sets: 10441456 (MoGene1.0st)   1425217_a_at (Mouse Genome 430 2.0 Array)   1427652_x_at (Mouse Genome 430 2.0 Array)   1427685_a_at (Mouse Genome 430 2.0 Array)   1431697_at (Mouse Genome 430 2.0 Array)   1431828_a_at (Mouse Genome 430 2.0 Array)   1452344_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000111456
Ensembl peptide - ENSMUSP00000111455
Ensembl peptide - ENSMUSP00000111457
Ensembl peptide - ENSMUSP00000138449
Ensembl peptide - ENSMUSP00000122381
Ensembl peptide - ENSMUSP00000122316
Ensembl peptide - ENSMUSP00000120006
Ensembl peptide - ENSMUSP00000115371
Ensembl peptide - ENSMUSP00000060382
Ensembl peptide - ENSMUSP00000079164
Ensembl peptide - ENSMUSP00000111450
Ensembl peptide - ENSMUSP00000111451
Ensembl peptide - ENSMUSP00000111452
Ensembl peptide - ENSMUSP00000111453
Ensembl peptide - ENSMUSP00000111454
NCBI entrez gene - 20975     See in Manteia.
MGI - MGI:1201671
RefSeq - XM_017317373
RefSeq - NM_001113351
RefSeq - NM_001113352
RefSeq - NM_001113353
RefSeq - NM_001290698
RefSeq - NM_011523
RefSeq - XM_006523202
RefSeq - XM_006523203
RefSeq - XM_006523204
RefSeq - XM_006523205
RefSeq - XM_006523206
RefSeq - XM_006523208
RefSeq - XM_006523212
RefSeq - XM_017317372
RefSeq Peptide - NP_001106824
RefSeq Peptide - NP_001277627
RefSeq Peptide - NP_035653
RefSeq Peptide - NP_001106822
RefSeq Peptide - NP_001106823
swissprot - D3YZB3
swissprot - F6U4I6
swissprot - F7BI35
swissprot - F8WHD8
swissprot - D3YZB2
swissprot - Q9D2G5
swissprot - D3YWM9
swissprot - S4R207
swissprot - E9Q4P5
swissprot - D3Z6E7
swissprot - D3YZB5
swissprot - D3YZB4
Ensembl - ENSMUSG00000023805
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SYNJ2ENSGALG00000013727Gallus gallus
 SYNJ2ENSG00000078269Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Synj1 / synaptojanin 1 / O43426*ENSMUSG0000002297344
Ocrl / Q6NVF0 / Inositol polyphosphate 5-phosphatase OCRL-1 / Q01968* / OCRL, inositol polyphosphate-5-phosphatase*ENSMUSG0000000117315
Inpp5b / Q8K337 / Type II inositol 1,4,5-trisphosphate 5-phosphatase / P32019* / inositol polyphosphate-5-phosphatase B*ENSMUSG0000002889414
Inpp5d / Q9ES52 / Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 / Q92835* / inositol polyphosphate-5-phosphatase D*ENSMUSG0000002628813
Inpp5j / P59644 / Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A / Q15735* / inositol polyphosphate-5-phosphatase J*ENSMUSG0000003457013
Inppl1 / Q6P549 / Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 / O15357* / inositol polyphosphate phosphatase like 1*ENSMUSG0000003273713
Inpp5e / Q9JII1 / 72 kDa inositol polyphosphate 5-phosphatase / Q9NRR6* / inositol polyphosphate-5-phosphatase E*ENSMUSG000000269259
Inpp5k / Q8C5L6 / inositol polyphosphate 5-phosphatase K / Q9BT40*ENSMUSG000000061277


Protein motifs (from Interpro)
Interpro ID Name
 IPR000300  Inositol polyphosphate-related phosphatase
 IPR000504  RNA recognition motif domain
 IPR002013  SAC domain
 IPR005135  Endonuclease/exonuclease/phosphatase
 IPR015047  Domain of unknown function DUF1866
 IPR034973  Synaptojanin-2, RNA recognition motif
 IPR034974  Synaptojanin-2
 IPR035979  RNA-binding domain superfamily
 IPR036691  Endonuclease/exonuclease/phosphatase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0046856 phosphatidylinositol dephosphorylation IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0045121 membrane raft IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity IDA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0034595 phosphatidylinositol phosphate 5-phosphatase activity IEA
 molecular_functionGO:0042578 phosphoric ester hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of PIPs at the plasma membrane
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000043 organ of Corti degeneration "a retrogressive impairment of function or destruction of the highly specialized epithelium in the floor of the ductus cochlearis" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Col1a1tm5(tetO-GFP/RNAi:Cdkn2a)Slowe/Col1a1+,Gt(ROSA)26Sortm1(Luc)Kael/Gt(ROSA)26Sortm1(rtTA*M2)Jae,Krastm4Tyj/Kras+,Tg(Scgb1a1-rtTA)1Jaw/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Smoc1tm1a(EUCOMM)Wtsi/Smoc1+
Genetic Background: C57BL/6N-Smoc1tm1a(EUCOMM)Wtsi/H

 MP:0002857 cochlear ganglion degeneration "loss of neural cell bodies in the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Col1a1tm5(tetO-GFP/RNAi:Cdkn2a)Slowe/Col1a1+,Gt(ROSA)26Sortm1(Luc)Kael/Gt(ROSA)26Sortm1(rtTA*M2)Jae,Krastm4Tyj/Kras+,Tg(Scgb1a1-rtTA)1Jaw/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0004362 cochlear hair cell degeneration "degeneration or loss of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Col1a1tm5(tetO-GFP/RNAi:Cdkn2a)Slowe/Col1a1+,Gt(ROSA)26Sortm1(Luc)Kael/Gt(ROSA)26Sortm1(rtTA*M2)Jae,Krastm4Tyj/Kras+,Tg(Scgb1a1-rtTA)1Jaw/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0004398 cochlear inner hair cell degeneration "degeneration or loss of the single row of flask-shaped inner hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Col1a1tm5(tetO-GFP/RNAi:Cdkn2a)Slowe/Col1a1+,Gt(ROSA)26Sortm1(Luc)Kael/Gt(ROSA)26Sortm1(rtTA*M2)Jae,Krastm4Tyj/Kras+,Tg(Scgb1a1-rtTA)1Jaw/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0004404 cochlear outer hair cell degeneration "degeneration or loss of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Col1a1tm5(tetO-GFP/RNAi:Cdkn2a)Slowe/Col1a1+,Gt(ROSA)26Sortm1(Luc)Kael/Gt(ROSA)26Sortm1(rtTA*M2)Jae,Krastm4Tyj/Kras+,Tg(Scgb1a1-rtTA)1Jaw/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0004528 fused outer hair cell stereocilia "coalescence of the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on cochlear outer hair cells, often resulting in giant stereocilia" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Col1a1tm5(tetO-GFP/RNAi:Cdkn2a)Slowe/Col1a1+,Gt(ROSA)26Sortm1(Luc)Kael/Gt(ROSA)26Sortm1(rtTA*M2)Jae,Krastm4Tyj/Kras+,Tg(Scgb1a1-rtTA)1Jaw/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0004533 fused inner hair cell stereocilia "coalescence of the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on cochlear inner hair cells, often resulting in giant stereocilia" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Col1a1tm5(tetO-GFP/RNAi:Cdkn2a)Slowe/Col1a1+,Gt(ROSA)26Sortm1(Luc)Kael/Gt(ROSA)26Sortm1(rtTA*M2)Jae,Krastm4Tyj/Kras+,Tg(Scgb1a1-rtTA)1Jaw/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0004740 sensorineural hearing loss "a form of progressive hearing loss due to a lesion of the auditory division of cranial nerve VIII or the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Col1a1tm5(tetO-GFP/RNAi:Cdkn2a)Slowe/Col1a1+,Gt(ROSA)26Sortm1(Luc)Kael/Gt(ROSA)26Sortm1(rtTA*M2)Jae,Krastm4Tyj/Kras+,Tg(Scgb1a1-rtTA)1Jaw/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0006325 impaired hearing "reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Col1a1tm5(tetO-GFP/RNAi:Cdkn2a)Slowe/Col1a1+,Gt(ROSA)26Sortm1(Luc)Kael/Gt(ROSA)26Sortm1(rtTA*M2)Jae,Krastm4Tyj/Kras+,Tg(Scgb1a1-rtTA)1Jaw/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Synj2mozart/Synj2mozart
Genetic Background: involves: C57BL/6 * CBA/H

Allelic Composition: Synj2mozart/Synj2mozart
Genetic Background: involves: BALB/c * C57BL/6

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Col1a1tm5(tetO-GFP/RNAi:Cdkn2a)Slowe/Col1a1+,Gt(ROSA)26Sortm1(Luc)Kael/Gt(ROSA)26Sortm1(rtTA*M2)Jae,Krastm4Tyj/Kras+,Tg(Scgb1a1-rtTA)1Jaw/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Synj2mozart/Synj2mozart
Genetic Background: involves: C57BL/6 * CBA/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000033335 Dnm2 / P39054 / Mus musculus dynamin 2 (Dnm2), transcript variant 5, mRNA. / P50570* / dynamin 2*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr