ENSMUSG00000001173


Mus musculus

Features
Gene ID: ENSMUSG00000001173
  
Biological name :Ocrl
  
Synonyms : Inositol polyphosphate 5-phosphatase OCRL-1 / Ocrl / Q6NVF0
  
Possible biological names infered from orthology : OCRL, inositol polyphosphate-5-phosphatase / Q01968
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: A5
Gene start: 47912387
Gene end: 47965868
  
Corresponding Affymetrix probe sets: 10599435 (MoGene1.0st)   1438284_at (Mouse Genome 430 2.0 Array)   1438396_at (Mouse Genome 430 2.0 Array)   1457313_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000001202
Ensembl peptide - ENSMUSP00000110665
Ensembl peptide - ENSMUSP00000110672
Ensembl peptide - ENSMUSP00000122084
NCBI entrez gene - 320634     See in Manteia.
MGI - MGI:109589
RefSeq - XM_011251008
RefSeq - XM_017318524
RefSeq - NM_177215
RefSeq Peptide - NP_796189
swissprot - Q6NVF0
swissprot - F7CAV3
swissprot - Q7TPR1
Ensembl - ENSMUSG00000001173
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ocrlENSDARG00000078106Danio rerio
 OCRLENSGALG00000003920Gallus gallus
 OCRLENSG00000122126Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Inpp5b / Q8K337 / Type II inositol 1,4,5-trisphosphate 5-phosphatase / P32019* / inositol polyphosphate-5-phosphatase B*ENSMUSG0000002889445
Synj2 / Q9D2G5 / Synaptojanin-2 / O15056*ENSMUSG0000002380524
Synj1 / synaptojanin 1 / O43426*ENSMUSG0000002297322
Inpp5j / P59644 / Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A / Q15735* / inositol polyphosphate-5-phosphatase J*ENSMUSG0000003457019
Inppl1 / Q6P549 / Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 / O15357* / inositol polyphosphate phosphatase like 1*ENSMUSG0000003273717
Inpp5d / Q9ES52 / Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 / Q92835* / inositol polyphosphate-5-phosphatase D*ENSMUSG0000002628817
Inpp5k / Q8C5L6 / inositol polyphosphate 5-phosphatase K / Q9BT40*ENSMUSG0000000612713
Inpp5e / Q9JII1 / 72 kDa inositol polyphosphate 5-phosphatase / Q9NRR6* / inositol polyphosphate-5-phosphatase E*ENSMUSG0000002692513


Protein motifs (from Interpro)
Interpro ID Name
 IPR000198  Rho GTPase-activating protein domain
 IPR000300  Inositol polyphosphate-related phosphatase
 IPR005135  Endonuclease/exonuclease/phosphatase
 IPR008936  Rho GTPase activation protein
 IPR013783  Immunoglobulin-like fold
 IPR031995  Inositol polyphosphate 5-phosphatase, clathrin binding domain
 IPR036691  Endonuclease/exonuclease/phosphatase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IGI
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0030030 cell projection organization IEA
 biological_processGO:0043087 regulation of GTPase activity ISO
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0046856 phosphatidylinositol dephosphorylation IDA
 biological_processGO:0060271 cilium assembly ISO
 cellular_componentGO:0001750 photoreceptor outer segment IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome ISO
 cellular_componentGO:0005794 Golgi apparatus ISS
 cellular_componentGO:0005802 trans-Golgi network ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005905 clathrin-coated pit IEA
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030136 clathrin-coated vesicle ISO
 cellular_componentGO:0030670 phagocytic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031901 early endosome membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity IDA
 molecular_functionGO:0005096 GTPase activator activity ISO
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0048365 Rac GTPase binding ISO
 molecular_functionGO:0052745 inositol phosphate phosphatase activity ISO


Pathways (from Reactome)
Pathway description
Synthesis of PIPs at the plasma membrane
Synthesis of PIPs at the Golgi membrane
Synthesis of IP2, IP, and Ins in the cytosol
Synthesis of IP3 and IP4 in the cytosol
Rho GTPase cycle
Golgi Associated Vesicle Biogenesis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Acetm9Keb/Acetm9Keb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Inpp5btm1Nbm/Inpp5btm1Nbm,Ocrltm1Nbm/Y,Tg(INPP5B)CNbm/0
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * FVB/N

Allelic Composition: Inpp5btm1Nbm/Inpp5btm1Nbm,Ocrltm1Nbm/Ocrltm1Nbm,Tg(INPP5B)CNbm/Tg(INPP5B)CNbm
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * FVB/N

Allelic Composition: Inpp5btm1Nbm/Inpp5btm1Nbm,Ocrltm1Nbm/Y,Tg(INPP5B)CNbm/Tg(INPP5B)CNbm
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * FVB/N

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Acetm9Keb/Acetm9Keb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Inpp5btm1Nbm/Inpp5btm1Nbm,Ocrltm1Nbm/Y,Tg(INPP5B)CNbm/0
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * FVB/N

Allelic Composition: Inpp5btm1Nbm/Inpp5btm1Nbm,Ocrltm1Nbm/Ocrltm1Nbm,Tg(INPP5B)CNbm/Tg(INPP5B)CNbm
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * FVB/N

Allelic Composition: Inpp5btm1Nbm/Inpp5btm1Nbm,Ocrltm1Nbm/Y,Tg(INPP5B)CNbm/Tg(INPP5B)CNbm
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * FVB/N

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Acetm9Keb/Acetm9Keb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Inpp5btm1Nbm/Inpp5btm1Nbm,Ocrltm1Nbm/Y,Tg(INPP5B)CNbm/0
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * FVB/N

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fn1tm2Feb/Fn1tm2Feb
Genetic Background: involves: 129X1/SvJ

 MP:0003311 aminoaciduria "excretion of amino acids in the urine, especially in excessive amounts" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:66560]
Show

Allelic Composition: Acetm9Keb/Acetm9Keb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Inpp5btm1Nbm/Inpp5btm1Nbm,Ocrltm1Nbm/Y,Tg(INPP5B)CNbm/0
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * FVB/N

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Acetm9Keb/Acetm9Keb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Inpp5btm1Nbm/Inpp5btm1Nbm,Ocrltm1Nbm/Y,Tg(INPP5B)CNbm/0
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * FVB/N

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Ntrk2tm1Rohr/Ntrk2tm1Rohr
Genetic Background: involves: ICR

 MP:0011555 increased urine microglobulin level "greater than the normal amount of any globulin (or any fragment of a globulin) of low molecular weight in the urine" [MGI:anna]
Show

Allelic Composition: Acetm9Keb/Acetm9Keb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Inpp5btm1Nbm/Inpp5btm1Nbm,Ocrltm1Nbm/Y,Tg(INPP5B)CNbm/0
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000033335 Dnm2 / P39054 / Mus musculus dynamin 2 (Dnm2), transcript variant 5, mRNA. / P50570* / dynamin 2*  / complex / reaction






 

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