ENSG00000204084


Homo sapiens

Features
Gene ID: ENSG00000204084
  
Biological name :INPP5B
  
Synonyms : inositol polyphosphate-5-phosphatase B / INPP5B / P32019
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: p34.3
Gene start: 37860697
Gene end: 37947057
  
Corresponding Affymetrix probe sets: 1563565_at (Human Genome U133 Plus 2.0 Array)   213643_s_at (Human Genome U133 Plus 2.0 Array)   213804_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000362117
Ensembl peptide - ENSP00000362115
Ensembl peptide - ENSP00000362118
Ensembl peptide - ENSP00000397748
Ensembl peptide - ENSP00000362112
Ensembl peptide - ENSP00000362114
NCBI entrez gene - 3633     See in Manteia.
OMIM - 147264
RefSeq - XM_017001209
RefSeq - XM_011541392
RefSeq - XM_011541393
RefSeq - XM_017001206
RefSeq - XM_017001207
RefSeq - XM_017001208
RefSeq - NM_001297434
RefSeq - NM_005540
RefSeq - XM_006710621
RefSeq Peptide - NP_001284363
RefSeq Peptide - NP_005531
swissprot - E7ESY0
swissprot - P32019
swissprot - B1ARF3
Ensembl - ENSG00000204084
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 inpp5bENSDARG00000103683Danio rerio
 INPP5BENSGALG00000001606Gallus gallus
 Inpp5bENSMUSG00000028894Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
OCRL / Q01968 / OCRL, inositol polyphosphate-5-phosphataseENSG0000012212645
SYNJ1 / O43426 / synaptojanin 1ENSG0000015908224
SYNJ2 / O15056 / synaptojanin 2ENSG0000007826922
INPP5J / Q15735 / inositol polyphosphate-5-phosphatase JENSG0000018513318
INPPL1 / O15357 / inositol polyphosphate phosphatase like 1ENSG0000016545818
INPP5D / Q92835 / inositol polyphosphate-5-phosphatase DENSG0000016891816
INPP5E / Q9NRR6 / inositol polyphosphate-5-phosphatase EENSG0000014838413
INPP5K / Q9BT40 / inositol polyphosphate-5-phosphatase KENSG0000013237612
Q96GF1 / RNF185 / ring finger protein 185ENSG000001389424


Protein motifs (from Interpro)
Interpro ID Name
 IPR000198  Rho GTPase-activating protein domain
 IPR000300  Inositol polyphosphate-related phosphatase
 IPR005135  Endonuclease/exonuclease/phosphatase
 IPR008936  Rho GTPase activation protein
 IPR013783  Immunoglobulin-like fold
 IPR031896  INPP5B, PH domain
 IPR036691  Endonuclease/exonuclease/phosphatase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0030317 flagellated sperm motility IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0043647 inositol phosphate metabolic process TAS
 biological_processGO:0046856 phosphatidylinositol dephosphorylation IEA
 biological_processGO:0051056 regulation of small GTPase mediated signal transduction TAS
 biological_processGO:0070613 regulation of protein processing IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005793 endoplasmic reticulum-Golgi intermediate compartment IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030670 phagocytic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031901 early endosome membrane IEA
 molecular_functionGO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity IEA
 molecular_functionGO:0005096 GTPase activator activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity IDA
 molecular_functionGO:0052659 inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity TAS
 molecular_functionGO:0052745 inositol phosphate phosphatase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of IP2, IP, and Ins in the cytosol
Synthesis of IP3 and IP4 in the cytosol
Rho GTPase cycle


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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