ENSDARG00000103683


Danio rerio

Features
Gene ID: ENSDARG00000103683
  
Biological name :inpp5b
  
Synonyms : inositol polyphosphate-5-phosphatase B / inpp5b
  
Possible biological names infered from orthology : P32019 / Q8K337 / Type II inositol 1,4,5-trisphosphate 5-phosphatase
  
Species: Danio rerio
  
Chr. number: 16
Strand: 1
Band:
Gene start: 4078240
Gene end: 4131804
  
Corresponding Affymetrix probe sets: Dr.15136.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000136834
Ensembl peptide - ENSDARP00000140577
NCBI entrez gene - 563543     See in Manteia.
swissprot - A0A0R4IMT3
swissprot - A0A0R4IVI6
ZFIN ID - ZDB-GENE-110411-228
Ensembl - ENSDARG00000103683
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 INPP5BENSGALG00000001606Gallus gallus
 INPP5BENSG00000204084Homo sapiens
 Inpp5bENSMUSG00000028894Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ocrl / oculocerebrorenal syndrome of Lowe / Q01968* / Q6NVF0* / OCRL, inositol polyphosphate-5-phosphatase* / Inositol polyphosphate 5-phosphatase OCRL-1 *ENSDARG0000007810643
synj1 / synaptojanin 1 / O43426*ENSDARG0000002501121
inppl1b / inositol polyphosphate phosphatase-like 1bENSDARG0000000144216
inpp5ja / inositol polyphosphate-5-phosphatase Ja / INPP5J* / P59644* / Q15735* / inositol polyphosphate-5-phosphatase J* / Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A *ENSDARG0000007854214
inppl1a / inositol polyphosphate phosphatase-like 1a / INPPL1* / O15357* / Q6P549* / inositol polyphosphate phosphatase like 1* / Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 *ENSDARG0000010422214
inpp5jb / inositol polyphosphate-5-phosphatase Jb / INPP5J* / P59644* / Q15735* / inositol polyphosphate-5-phosphatase J* / Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A *ENSDARG0000009335914
inpp5d / inositol polyphosphate-5-phosphatase D / Q92835* / Q9ES52* / Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 *ENSDARG0000007428314
inpp5ka / inositol polyphosphate-5-phosphatase Ka / INPP5K* / Q9BT40* / Q8C5L6* / inositol polyphosphate-5-phosphatase K*ENSDARG0000009956313
inpp5e / inositol polyphosphate-5-phosphatase E / Q9JII1* / Q9NRR6* / 72 kDa inositol polyphosphate 5-phosphatase *ENSDARG0000010392613
inpp5kb / inositol polyphosphate-5-phosphatase Kb / INPP5K* / Q9BT40* / Q8C5L6* / inositol polyphosphate-5-phosphatase K*ENSDARG0000007861812


Protein motifs (from Interpro)
Interpro ID Name
 IPR000198  Rho GTPase-activating protein domain
 IPR000300  Inositol polyphosphate-related phosphatase
 IPR005135  Endonuclease/exonuclease/phosphatase
 IPR008936  Rho GTPase activation protein
 IPR013783  Immunoglobulin-like fold
 IPR031896  INPP5B, PH domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0032402 melanosome transport IMP
 biological_processGO:0039023 pronephric duct morphogenesis IMP
 biological_processGO:0046856 phosphatidylinositol dephosphorylation IEA
 biological_processGO:0060271 cilium assembly IMP
 biological_processGO:0070121 Kupffer"s vesicle development IMP
 biological_processGO:0071871 response to epinephrine IMP
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0052745 inositol phosphate phosphatase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of IP2, IP, and Ins in the cytosol
Synthesis of IP3 and IP4 in the cytosol
Rho GTPase cycle


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000001 Kupffer s vesicle Kupffers vesicle decreased size , abnormal
Kupffers vesicle cilium decreased length , abnormal
Kupffers vesicle cilium decreased amount , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
Show

 ZFA:0000150 pronephric duct pronephric duct cilium morphology , abnormal
pronephric duct cilium decreased length , abnormal
Show

 ZFA:0001094 whole organism whole organism dead , abnormal
whole organism anterior-posterior axis asymmetrical , abnormal
Show

 ZFA:0001117 post-vent region post-vent region kinked , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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