ENSDARG00000103926


Danio rerio

Features
Gene ID: ENSDARG00000103926
  
Biological name :inpp5e
  
Synonyms : inositol polyphosphate-5-phosphatase E / inpp5e
  
Possible biological names infered from orthology : 72 kDa inositol polyphosphate 5-phosphatase / Q9JII1 / Q9NRR6
  
Species: Danio rerio
  
Chr. number: 5
Strand: -1
Band:
Gene start: 65065968
Gene end: 65082107
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000135950
Ensembl peptide - ENSDARP00000137223
NCBI entrez gene - 606579     See in Manteia.
RefSeq - NM_001102619
RefSeq Peptide - NP_001096089
swissprot - A0A0R4ISZ8
swissprot - A0A0R4INV4
ZFIN ID - ZDB-GENE-050809-23
Ensembl - ENSDARG00000103926
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 INPP5EENSGALG00000001964Gallus gallus
 INPP5EENSG00000148384Homo sapiens
 Inpp5eENSMUSG00000026925Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
synj1 / synaptojanin 1 / O43426*ENSDARG0000002501122
inpp5b / inositol polyphosphate-5-phosphatase B / P32019* / Q8K337* / Type II inositol 1,4,5-trisphosphate 5-phosphatase *ENSDARG0000010368320
inppl1a / inositol polyphosphate phosphatase-like 1a / INPPL1* / O15357* / Q6P549* / inositol polyphosphate phosphatase like 1* / Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 *ENSDARG0000010422219
inpp5d / inositol polyphosphate-5-phosphatase D / Q92835* / Q9ES52* / Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 *ENSDARG0000007428319
inppl1b / inositol polyphosphate phosphatase-like 1bENSDARG0000000144219
ocrl / oculocerebrorenal syndrome of Lowe / Q01968* / Q6NVF0* / OCRL, inositol polyphosphate-5-phosphatase* / Inositol polyphosphate 5-phosphatase OCRL-1 *ENSDARG0000007810619
inpp5jb / inositol polyphosphate-5-phosphatase Jb / INPP5J* / P59644* / Q15735* / inositol polyphosphate-5-phosphatase J* / Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A *ENSDARG0000009335917
inpp5kb / inositol polyphosphate-5-phosphatase Kb / INPP5K* / Q9BT40* / Q8C5L6* / inositol polyphosphate-5-phosphatase K*ENSDARG0000007861816
inpp5ka / inositol polyphosphate-5-phosphatase Ka / INPP5K* / Q9BT40* / Q8C5L6* / inositol polyphosphate-5-phosphatase K*ENSDARG0000009956316
inpp5ja / inositol polyphosphate-5-phosphatase Ja / INPP5J* / P59644* / Q15735* / inositol polyphosphate-5-phosphatase J* / Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A *ENSDARG0000007854215


Protein motifs (from Interpro)
Interpro ID Name
 IPR000300  Inositol polyphosphate-related phosphatase
 IPR005135  Endonuclease/exonuclease/phosphatase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0032402 melanosome transport IMP
 biological_processGO:0035850 epithelial cell differentiation involved in kidney development IMP
 biological_processGO:0046856 phosphatidylinositol dephosphorylation IEA
 biological_processGO:0060041 retina development in camera-type eye IMP
 biological_processGO:0060271 cilium assembly IMP
 biological_processGO:1902017 regulation of cilium assembly IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of PIPs at the Golgi membrane
ARL13B-mediated ciliary trafficking of INPP5E


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000001 Kupffer s vesicle Kupffers vesicle cilium decreased length , abnormal
Kupffers vesicle cilium decreased amount , abnormal
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 ZFA:0000150 pronephric duct pronephric duct cilium decreased length , abnormal
pronephric duct filamentous actin mislocalised , abnormal
pronephric duct establishment of epithelial cell apical/basal polarity decreased process quality , abnormal
pronephric duct actin filament bundle distribution decreased process quality , abnormal
pronephric duct has number of pronephric duct motile cilium, ameliorated
pronephric duct has fewer parts of type pronephric duct motile cilium, abnormal
pronephric duct 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate mislocalised , abnormal
pronephric duct 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate mislocalised , abnormal
pronephric duct apical plasma membrane absent , abnormal
pronephric duct apical plasma membrane mislocalised , abnormal
pronephric duct ciliary basal body mislocalised , abnormal
pronephric duct cilium assembly occurrence , ameliorated
pronephric duct cilium assembly decreased occurrence , abnormal
pronephric duct ciliary basal body-plasma membrane docking decreased process quality , abnormal
pronephric duct cystic , abnormal
pronephric duct ciliary basal body absent , abnormal
pronephric duct 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate position , ameliorated
pronephric duct apical plasma membrane amount , ameliorated
pronephric duct apical plasma membrane decreased amount , abnormal
pronephric duct establishment of epithelial cell apical/basal polarity process quality , ameliorated
pronephric duct inositol phosphate-mediated signaling process quality , ameliorated
pronephric duct inositol phosphate-mediated signaling decreased process quality , abnormal
pronephric duct 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate position , ameliorated
pronephric duct apical plasma membrane position , ameliorated
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 ZFA:0000151 pronephros pronephros renal filtration rate , ameliorated
pronephros renal filtration decreased rate , abnormal
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 ZFA:0001117 post-vent region post-vent region curved dorsal , abnormal
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 ZFA:0001557 pronephric glomerulus pronephric glomerulus morphology , ameliorated
pronephric glomerulus cystic , abnormal
pronephric glomerulus cystic , exacerbated
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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