ENSG00000164400


Homo sapiens

Features
Gene ID: ENSG00000164400
  
Biological name :CSF2
  
Synonyms : colony stimulating factor 2 / CSF2 / P04141
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: q31.1
Gene start: 132073790
Gene end: 132076170
  
Corresponding Affymetrix probe sets: 210228_at (Human Genome U133 Plus 2.0 Array)   210229_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000296871
NCBI entrez gene - 1437     See in Manteia.
OMIM - 138960
RefSeq - NM_000758
RefSeq Peptide - NP_000749
swissprot - P04141
Ensembl - ENSG00000164400
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Csf2ENSMUSG00000018916Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000773  Granulocyte-macrophage colony-stimulating factor
 IPR009079  Four-helical cytokine-like, core


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0001821 histamine secretion IEA
 biological_processGO:0001892 embryonic placenta development IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0010744 positive regulation of macrophage derived foam cell differentiation IDA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0030223 neutrophil differentiation IEA
 biological_processGO:0030224 monocyte differentiation IEA
 biological_processGO:0032747 positive regulation of interleukin-23 production IDA
 biological_processGO:0034021 response to silicon dioxide IEA
 biological_processGO:0034405 response to fluid shear stress IEA
 biological_processGO:0042045 epithelial fluid transport IEA
 biological_processGO:0042116 macrophage activation IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IDA
 biological_processGO:0043011 myeloid dendritic cell differentiation IEA
 biological_processGO:0045187 regulation of circadian sleep/wake cycle, sleep IEA
 biological_processGO:0045637 regulation of myeloid cell differentiation TAS
 biological_processGO:0045740 positive regulation of DNA replication IDA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045918 negative regulation of cytolysis IDA
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071803 positive regulation of podosome assembly IDA
 biological_processGO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus IDA
 biological_processGO:0097028 dendritic cell differentiation IDA
 biological_processGO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 molecular_functionGO:0004713 protein tyrosine kinase activity TAS
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005129 granulocyte macrophage colony-stimulating factor receptor binding TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity IEA


Pathways (from Reactome)
Pathway description
Interleukin-3, Interleukin-5 and GM-CSF signaling
RAF/MAP kinase cascade
Interleukin-10 signaling
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells
Interleukin receptor SHC signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100368 CSF2RB / P32927 / colony stimulating factor 2 receptor beta common subunit  / complex / reaction
 ENSG00000121879 P42336 / PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha  / reaction / complex
 ENSG00000198223 CSF2RA / P15509 / colony stimulating factor 2 receptor alpha subunit  / reaction / complex
 ENSG00000145675 P27986 / PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1  / complex / reaction
 ENSG00000051382 P42338 / PIK3CB / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta  / reaction / complex
 ENSG00000179295 PTPN11 / Q06124 / protein tyrosine phosphatase, non-receptor type 11  / complex / reaction
 ENSG00000164400 CSF2 / P04141 / colony stimulating factor 2  / complex
 ENSG00000173757 P51692 / STAT5B / signal transducer and activator of transcription 5B  / reaction / complex
 ENSG00000171608 O00329 / PIK3CD / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta  / reaction / complex
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / reaction / complex
 ENSG00000096968 JAK2 / O60674 / Janus kinase 2  / complex / reaction
 ENSG00000126561 P42229 / STAT5A / signal transducer and activator of transcription 5A  / complex / reaction
 ENSG00000033327 GAB2 / Q9UQC2 / GRB2 associated binding protein 2  / complex
 ENSG00000111679 PTPN6 / P29350 / protein tyrosine phosphatase, non-receptor type 6  / complex / reaction
 ENSG00000072062 P17612 / PRKACA / protein kinase cAMP-activated catalytic subunit alpha  / reaction
 ENSG00000165458 INPPL1 / O15357 / inositol polyphosphate phosphatase like 1  / complex / reaction
 ENSG00000164924 YWHAZ / P63104 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta  / complex / reaction
 ENSG00000168918 INPP5D / Q92835 / inositol polyphosphate-5-phosphatase D  / reaction / complex
 ENSG00000160691 SHC1 / P29353 / SHC adaptor protein 1  / complex / reaction
 ENSG00000115904 SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1  / reaction / complex






 

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