ENSG00000168546


Homo sapiens

Features
Gene ID: ENSG00000168546
  
Biological name :GFRA2
  
Synonyms : GDNF family receptor alpha 2 / GFRA2 / O00451
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: -1
Band: p21.3
Gene start: 21690403
Gene end: 21812357
  
Corresponding Affymetrix probe sets: 205721_at (Human Genome U133 Plus 2.0 Array)   205722_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000429206
Ensembl peptide - ENSP00000430622
Ensembl peptide - ENSP00000429979
Ensembl peptide - ENSP00000429445
Ensembl peptide - ENSP00000306654
Ensembl peptide - ENSP00000428518
Ensembl peptide - ENSP00000428721
NCBI entrez gene - 2675     See in Manteia.
OMIM - 601956
RefSeq - XM_011544484
RefSeq - NM_001165038
RefSeq - NM_001165039
RefSeq - NM_001495
RefSeq - XM_006716327
RefSeq Peptide - NP_001158511
RefSeq Peptide - NP_001486
RefSeq Peptide - NP_001158510
swissprot - O00451
swissprot - E5RGR6
swissprot - E5RJ44
swissprot - J3KNF0
Ensembl - ENSG00000168546
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gfra2aENSDARG00000042723Danio rerio
 gfra2bENSDARG00000044015Danio rerio
 GFRA2ENSGALG00000032856Gallus gallus
 Gfra2ENSMUSG00000022103Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GFRA1 / P56159 / GDNF family receptor alpha 1ENSG0000015189248
GFRA3 / O60609 / GDNF family receptor alpha 3ENSG0000014601328
GFRA4 / Q9GZZ7 / GDNF family receptor alpha 4ENSG0000012586121


Protein motifs (from Interpro)
Interpro ID Name
 IPR003438  Glial cell line-derived neurotrophic factor receptor
 IPR003504  Glial cell line-derived neurotrophic factor receptor alpha 2
 IPR016017  GDNF/GAS1
 IPR017372  Glial cell line-derived neurotrophic factor receptor, alpha 1/2
 IPR037193  GDNF receptor alpha


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway TAS
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007411 axon guidance TAS
 biological_processGO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein IEA
 biological_processGO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0019898 extrinsic component of membrane TAS
 cellular_componentGO:0031225 anchored component of membrane IEA
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0016167 glial cell-derived neurotrophic factor receptor activity TAS


Pathways (from Reactome)
Pathway description
NCAM1 interactions
RAF/MAP kinase cascade
RET signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000124181 PLCG1 / P19174 / phospholipase C gamma 1  / reaction / complex
 ENSG00000125650 PSPN / O60542 / persephin  / complex / reaction
 ENSG00000109458 GAB1 / Q13480 / GRB2 associated binding protein 1  / complex
 ENSG00000141738 GRB7 / Q14451 / growth factor receptor bound protein 7  / reaction / complex
 ENSG00000115904 SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1  / complex / reaction
 ENSG00000117407 ARTN / Q5T4W7 / artemin  / reaction / complex
 ENSG00000171608 O00329 / PIK3CD / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta  / complex
 ENSG00000197122 SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase  / complex / reaction
 ENSG00000125861 GFRA4 / Q9GZZ7 / GDNF family receptor alpha 4  / reaction / complex
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / reaction / complex
 ENSG00000165731 RET / P07949 / ret proto-oncogene  / reaction / complex
 ENSG00000146013 GFRA3 / O60609 / GDNF family receptor alpha 3  / reaction / complex
 ENSG00000179295 PTPN11 / Q06124 / protein tyrosine phosphatase, non-receptor type 11  / reaction / complex
 ENSG00000171119 NRTN / Q99748 / neurturin  / complex / reaction
 ENSG00000121879 P42336 / PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha  / complex
 ENSG00000168546 GFRA2 / O00451 / GDNF family receptor alpha 2  / reaction / complex
 ENSG00000145675 P27986 / PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1  / complex
 ENSG00000168621 GDNF / P39905 / glial cell derived neurotrophic factor  / reaction / complex
 ENSG00000033327 GAB2 / Q9UQC2 / GRB2 associated binding protein 2  / complex
 ENSG00000076864 P47736 / RAP1GAP / RAP1 GTPase activating protein  / reaction / complex
 ENSG00000166225 FRS2 / Q8WU20 / fibroblast growth factor receptor substrate 2  / complex / reaction
 ENSG00000051382 P42338 / PIK3CB / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta  / complex
 ENSG00000106070 GRB10 / Q13322 / growth factor receptor bound protein 10  / reaction / complex
 ENSG00000151892 GFRA1 / P56159 / GDNF family receptor alpha 1  / reaction / complex
 ENSG00000160691 SHC1 / P29353 / SHC adaptor protein 1  / reaction / complex






 

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