ENSDARG00000042723


Danio rerio

Features
Gene ID: ENSDARG00000042723
  
Biological name :gfra2a
  
Synonyms : GDNF family receptor alpha 2a / gfra2a
  
Possible biological names infered from orthology : GDNF family receptor alpha 2 / GFRA2 / O00451 / O08842
  
Species: Danio rerio
  
Chr. number: 8
Strand: -1
Band:
Gene start: 42059495
Gene end: 42238543
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000062696
NCBI entrez gene - 405794     See in Manteia.
RefSeq - NM_001017996
RefSeq Peptide - NP_001017996
swissprot - B0S6A6
ZFIN ID - ZDB-GENE-040630-1
Ensembl - ENSDARG00000042723
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GFRA2ENSGALG00000032856Gallus gallus
 GFRA2ENSG00000168546Homo sapiens
 Gfra2ENSMUSG00000022103Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
gfra2b / GDNF family receptor alpha 2b / GFRA2* / O00451* / O08842* / GDNF family receptor alpha 2*ENSDARG0000004401540
gfra1b / gdnf family receptor alpha 1b / GFRA1* / P56159* / P97785* / GDNF family receptor alpha 1*ENSDARG0000010256438
gfra4b / GDNF family receptor alpha 4b / GFRA4* / Q9GZZ7* / Q9JJT2* / GDNF family receptor alpha 4*ENSDARG0000007458232
gfra4a / GDNF family receptor alpha 4a / GFRA4* / Q9GZZ7* / Q9JJT2* / GDNF family receptor alpha 4*ENSDARG0000005665132
gfra3 / GDNF family receptor alpha 3 / O35118* / O60609*ENSDARG0000008770431
gfra1a / gdnf family receptor alpha 1a / GFRA1* / P56159* / P97785* / GDNF family receptor alpha 1*ENSDARG000000997329


Protein motifs (from Interpro)
Interpro ID Name
 IPR003438  Glial cell line-derived neurotrophic factor receptor
 IPR016017  GDNF/GAS1
 IPR017372  Glial cell line-derived neurotrophic factor receptor, alpha 1/2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0048484 enteric nervous system development IGI
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031225 anchored component of membrane IEA


Pathways (from Reactome)
Pathway description
RAF/MAP kinase cascade
RET signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000038442 plcg1 / phospholipase C, gamma 1 / P19174* / Q62077* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 *  / reaction / complex
 ENSDARG00000105276 grb2a / growth factor receptor-bound protein 2a / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / complex / reaction
 ENSDARG00000045873 frs2a / fibroblast growth factor receptor substrate 2a / FRS2* / Q8C180* / Q8WU20* / fibroblast growth factor receptor substrate 2*  / complex / reaction
 ENSDARG00000035308 grb10b / growth factor receptor-bound protein 10b / GRB10* / Q60760* / Q13322* / growth factor receptor bound protein 10*  / complex / reaction
 ENSDARG00000008107 src / Q1JPZ3 / v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyr...  / complex / reaction
 ENSDARG00000053272 si:dkey-166d12.2 / P47736* / RAP1GAP* / RAP1 GTPase activating protein*  / complex / reaction
 ENSDARG00000073731 dok4 / docking protein 4 / Q8TEW6* / Q99KE3*  / complex / reaction
 ENSDARG00000075437 shc1 / SHC (Src homology 2 domain containing) transforming protein 1 / P98083* / P29353* / SHC adaptor protein 1* / SHC-transforming protein 1 *  / complex / reaction
 ENSDARG00000075456 pik3ca / phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha / P42336* / P42337* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform *  / complex
 ENSDARG00000038524 pik3r1 / phosphoinositide-3-kinase, regulatory subunit 1 (alpha) / P26450* / P27986* / phosphoinositide-3-kinase regulatory subunit 1*  / complex
 ENSDARG00000042723 gfra2a / GDNF family receptor alpha 2a / GFRA2* / O00451* / O08842* / GDNF family receptor alpha 2*  / complex / reaction
 ENSDARG00000078108 dok1a / docking protein 1a / DOK1* / P97465* / Q99704* / docking protein 1*  / reaction / complex
 ENSDARG00000063032 dok6 / docking protein 6 / Q2MHE5* / Q6PKX4*  / reaction / complex
 ENSDARG00000020334 ptpn11a / protein tyrosine phosphatase, non-receptor type 11, a / PTPN11* / P35235* / Q06124* / Tyrosine-protein phosphatase non-receptor type 11 * / protein tyrosine phosphatase, non-recep...  / complex / reaction
 ENSDARG00000087704 gfra3 / GDNF family receptor alpha 3 / O35118* / O60609*  / reaction / complex
 ENSDARG00000074582 gfra4b / GDNF family receptor alpha 4b / GFRA4* / Q9GZZ7* / Q9JJT2* / GDNF family receptor alpha 4*  / reaction / complex
 ENSDARG00000075253 pik3cb / phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta / P42338* / Q8BTI9* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform *  / complex
 ENSDARG00000037353 frs2b / fibroblast growth factor receptor substrate 2b / FRS2* / Q8C180* / Q8WU20* / fibroblast growth factor receptor substrate 2*  / complex / reaction
 ENSDARG00000002013 grb10a / growth factor receptor-bound protein 10a / GRB10* / Q60760* / Q13322* / growth factor receptor bound protein 10*  / complex / reaction
 ENSDARG00000038059 grb2b / growth factor receptor-bound protein 2b / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / complex / reaction
 ENSDARG00000044015 gfra2b / GDNF family receptor alpha 2b / GFRA2* / O00451* / O08842* / GDNF family receptor alpha 2*  / complex / reaction
 ENSDARG00000037018 gab1 / GRB2-associated binding protein 1 / Q13480* / Q9QYY0*  / complex
 ENSDARG00000055305 ret / ret proto-oncogene receptor tyrosine kinase / P07949* / P35546* / ret proto-oncogene* / Proto-onco tyrosine-protein kinase receptor Ret Soluble RET kinase fragment Extracellular cell-...  / reaction / complex
 ENSDARG00000079849 nrtn / neurturin / P97463* / Q99748*  / reaction / complex
 ENSDARG00000039959 gdnfa / glial cell derived neurotrophic factor a / GDNF* / P39905* / P48540* / glial cell derived neurotrophic factor* / Mus musculus glial cell line derived neurotrophic factor (Gdnf), tra...  / reaction / complex
 ENSDARG00000105120 gab2 / GRB2-associated binding protein 2 / GAB4* / Q2WGN9* / Q9UQC2* / GRB2 associated binding protein family member 4*  / complex






 

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