ENSDARG00000098497


Danio rerio

Features
Gene ID: ENSDARG00000098497
  
Biological name :hrasa
  
Synonyms : hrasa / v-Ha-ras Harvey rat sarcoma viral oncogene homolog a
  
Possible biological names infered from orthology : GTPase HRas GTPase HRas, N-terminally processed / HRAS / HRas proto-oncogene, GTPase / P01112 / Q61411
  
Species: Danio rerio
  
Chr. number: 25
Strand: -1
Band:
Gene start: 25395590
Gene end: 25434479
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000142010
NCBI entrez gene - 550286     See in Manteia.
RefSeq - NM_001017623
RefSeq Peptide - NP_001017623
swissprot - F1QNG4
ZFIN ID - ZDB-GENE-050417-95
Ensembl - ENSDARG00000098497
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 H-RASENSGALG00000034526Gallus gallus
 H-RASENSGALG00000029260Gallus gallus
 HRASENSG00000174775Homo sapiens
 HrasENSMUSG00000025499Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
hrasb / -Ha-ras Harvey rat sarcoma viral oncogene homolog b / HRAS* / P01112* / Q61411* / HRas proto-oncogene, GTPase* / GTPase HRas GTPase HRas, N-terminally processed*ENSDARG0000000565197
nras / NRAS proto-oncogene, GTPase / P01111* / neuroblastoma ras oncogene*ENSDARG0000003822587
kras / v-Ki-ras2 Kirsten rat sarcoma viral oncogene homologENSDARG0000001084485
zgc:55558ENSDARG0000001316183
rras2 / RAS related 2 / P62070* / P62071* / Ras-related protein R-Ras2 *ENSDARG0000003625255
MRAS / si:ch73-116o1.2 / O08989* / O14807* / muscle and microspikes RAS* / muscle RAS oncogene homolog*ENSDARG0000007528553
rras / RAS related / P10301* / P10833* / related RAS viral (r-ras) oncogene*ENSDARG0000000655353
mras / muscle RAS oncogene homolog / O08989* / O14807* / muscle and microspikes RAS*ENSDARG0000006286552
ralab / v-ral simian leukemia viral oncogene homolog Ab (ras related) / RALA* / P63321* / P11233* / RAS like proto-oncogene A* / Ras-related protein Ral-A *ENSDARG0000001625349
ralaa / v-ral simian leukemia viral oncogene homolog Aa (ras related) / RALA* / P63321* / P11233* / RAS like proto-oncogene A* / Ras-related protein Ral-A *ENSDARG0000004546349
ralba / v-ral simian leukemia viral oncogene homolog Ba (ras related) / RALB* / Q9JIW9* / P11234* / RAS like proto-oncogene B* / Ras-related protein Ral-B *ENSDARG0000004077847
RERG / si:cabz01085950.1 / Q96A58* / RAS like estrogen regulated growth inhibitor*ENSDARG0000010463235
zgc:110699ENSDARG0000001747433
Q7SZ59 / rasl12 / RAS-like, family 12 / Q9NYN1*ENSDARG0000000270131
rergla / RERG/RAS-like a / RERGL* / Q9H628* / RERG like* / RERG/RAS-like*ENSDARG0000001939630
zgc:64022ENSDARG0000007070529
si:dkeyp-59c12.1ENSDARG0000003811229
rem1 / RAS (RAD and GEM)-like GTP-binding 1 / O75628* / O35929* / GTP-binding protein REM 1 * / RRAD and GEM like GTPase 1*ENSDARG0000002054429
rrad / Ras-related associated with diabetes / P55042* / RRAD, Ras related glycolysis inhibitor and calcium channel regulator*ENSDARG0000005201129
gem / GTP binding protein overexpressed in skeletal muscle / P55040* / P55041* / GTP-binding protein GEM *ENSDARG0000002911228


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR020849  Small GTPase superfamily, Ras-type
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005525 GTP binding IEA


Pathways (from Reactome)
Pathway description
Activation of RAS in B cells
SHC1 events in ERBB4 signaling
Signaling by SCF-KIT
p38MAPK events
GRB2 events in EGFR signaling
SHC1 events in EGFR signaling
Downstream signal transduction
GRB2 events in ERBB2 signaling
Tie2 Signaling
EGFR Transactivation by Gastrin
DAP12 signaling
FCERI mediated MAPK activation
NCAM signaling for neurite out-growth
EPHB-mediated forward signaling
Ras activation upon Ca2+ influx through NMDA receptor
VEGFR2 mediated cell proliferation
CD209 (DC-SIGN) signaling
SHC-mediated cascade:FGFR1
FRS-mediated FGFR1 signaling
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
SHC-mediated cascade:FGFR3
FRS-mediated FGFR3 signaling
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
Regulation of RAS by GAPs
RAF activation
RAF/MAP kinase cascade
MAP2K and MAPK activation
Negative regulation of MAPK pathway
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
MET activates RAS signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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