ENSMUSG00000025372


Mus musculus

Features
Gene ID: ENSMUSG00000025372
  
Biological name :Baiap2
  
Synonyms : Baiap2 / Brain-specific angiosis inhibitor 1-associated protein 2 / Q8BKX1
  
Possible biological names infered from orthology : BAI1 associated protein 2 / Q9UQB8
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: E2
Gene start: 119942763
Gene end: 120006782
  
Corresponding Affymetrix probe sets: 10383289 (MoGene1.0st)   1425656_a_at (Mouse Genome 430 2.0 Array)   1435128_at (Mouse Genome 430 2.0 Array)   1451027_at (Mouse Genome 430 2.0 Array)   1451028_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000074674
Ensembl peptide - ENSMUSP00000101838
Ensembl peptide - ENSMUSP00000101840
Ensembl peptide - ENSMUSP00000026436
Ensembl peptide - ENSMUSP00000099310
NCBI entrez gene - 108100     See in Manteia.
MGI - MGI:2137336
RefSeq - XM_006531969
RefSeq - NM_001037754
RefSeq - NM_001037755
RefSeq - NM_130862
RefSeq - XM_006531966
RefSeq - XM_006531967
RefSeq - XM_006531968
RefSeq Peptide - NP_001032843
RefSeq Peptide - NP_001032844
RefSeq Peptide - NP_570932
swissprot - Q3UKP6
swissprot - Q8BKX1
swissprot - B1AZ46
Ensembl - ENSMUSG00000025372
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 baiap2aENSDARG00000062799Danio rerio
 BAIAP2ENSGALG00000042538Gallus gallus
 BAIAP2ENSG00000175866Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9DBJ3 / Baiap2l1 / Brain-specific angiosis inhibitor 1-associated protein 2-like protein 1 / Q9UHR4* / BAI1 associated protein 2 like 1*ENSMUSG0000003885938
Q80Y61 / Baiap2l2 / Brain-specific angiosis inhibitor 1-associated protein 2-like protein 2 / Q6UXY1* / BAI1 associated protein 2 like 2*ENSMUSG0000001812626


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR013606  IMD/I-BAR domain
 IPR027267  AH/BAR domain superfamily
 IPR027681  I-BAR domain containing protein IRSp53/IRTKS/Pinkbar
 IPR030128  I-BAR domain containing protein IRSp53
 IPR035594  IRSp53, SH3 domain
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007009 plasma membrane organization IEA
 biological_processGO:0007266 Rho protein signal transduction TAS
 biological_processGO:0007420 brain development IEA
 biological_processGO:0008286 insulin receptor signaling pathway IBA
 biological_processGO:0008360 regulation of cell shape IMP
 biological_processGO:0009617 response to bacterium ISS
 biological_processGO:0010976 positive regulation of neuron projection development IEA
 biological_processGO:0016358 dendrite development IMP
 biological_processGO:0030182 neuron differentiation IEA
 biological_processGO:0030838 positive regulation of actin filament polymerization IBA
 biological_processGO:0032956 regulation of actin cytoskeleton organization IEA
 biological_processGO:0035418 protein localization to synapse IEA
 biological_processGO:0048167 regulation of synaptic plasticity IMP
 biological_processGO:0051017 actin filament bundle assembly IGI
 biological_processGO:0051764 actin crosslink formation IMP
 biological_processGO:0061003 positive regulation of dendritic spine morphogenesis IEA
 biological_processGO:0071364 cellular response to epidermal growth factor stimulus IEA
 biological_processGO:0098609 cell-cell adhesion IEA
 biological_processGO:1905232 cellular response to L-glutamate IEA
 biological_processGO:2000251 positive regulation of actin cytoskeleton reorganization IBA
 biological_processGO:2000463 positive regulation of excitatory postsynaptic potential IEA
 cellular_componentGO:0001726 ruffle IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005791 rough endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005913 cell-cell adherens junction ISO
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0015629 actin cytoskeleton IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030141 secretory granule IEA
 cellular_componentGO:0030175 filopodium IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IDA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0043198 dendritic shaft IEA
 cellular_componentGO:0044306 neuron projection terminus IEA
 cellular_componentGO:0060076 excitatory synapse IEA
 cellular_componentGO:0061845 neuron projection branch point IEA
 cellular_componentGO:0061846 dendritic spine cytoplasm IEA
 cellular_componentGO:0097060 synaptic membrane IEA
 cellular_componentGO:0098793 presynapse IEA
 cellular_componentGO:0098794 postsynapse IEA
 molecular_functionGO:0001221 transcription cofactor binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008093 cytoskeletal adaptor activity IEA
 molecular_functionGO:0030165 PDZ domain binding IEA
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0070064 proline-rich region binding ISO
 molecular_functionGO:0097110 scaffold protein binding IEA
 molecular_functionGO:0098641 cadherin binding involved in cell-cell adhesion ISO


Pathways (from Reactome)
Pathway description
Regulation of actin dynamics for phagocytic cup formation
VEGFA-VEGFR2 Pathway
RHO GTPases Activate WASPs and WAVEs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001458 abnormal object recognition memory "defects in the ability to recognize objects that the animal has previously encountered; recognition is measured by relative amount of time exploring objects, which should decrease upon subsequent or multiple presentations of the same object when presented with novel objects at the same time" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae
Genetic Background: involves: 129S1/Sv * 129S4/SvJae

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae
Genetic Background: involves: 129S1/Sv * 129S4/SvJae

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae
Genetic Background: involves: 129S1/Sv * 129S4/SvJae

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Aspatm1b(EUCOMM)Wtsi/Aspatm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Aspatm1b(EUCOMM)Wtsi/Ieg

 MP:0003008 enhanced long term potentiation "greater than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, J:81922]
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Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae
Genetic Background: involves: 129S1/Sv * 129S4/SvJae

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae
Genetic Background: involves: 129S1/Sv * 129S4/SvJae

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Baiap2l2tm1b(EUCOMM)Hmgu/Baiap2l2tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Baiap2l2tm1b(EUCOMM)Hmgu/Ics

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026842 Abl1 / P00520 / c-abl oncogene 1, non-receptor tyrosine kinase / P00519* / ABL proto-oncogene 1, non-receptor tyrosine kinase*  / reaction
 ENSMUSG00000062825 Actg1 / P63260 / Actin, cytoplasmic 2 Actin, cytoplasmic 2, N-terminally processed / P63261* / actin gamma 1*  / complex / reaction
 ENSMUSG00000063358 Mapk1 / P63085 / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA. / P28482* / mitogen-activated protein kinase 1*  / reaction
 ENSMUSG00000063065 Mapk3 / Q63844 / Mitogen-activated protein kinase 3 / P27361*  / reaction
 ENSMUSG00000001847 Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*  / reaction / complex
 ENSMUSG00000029580 Actb / P60710 / Actin, cytoplasmic 1 Actin, cytoplasmic 1, N-terminally processed / POTEJ* / P60709* / P0CG39* / actin beta* / POTE ankyrin domain family member J*  / reaction / complex






 

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