ENSG00000256812


Homo sapiens

Features
Gene ID: ENSG00000256812
  
Biological name :CAPNS2
  
Synonyms : calpain small subunit 2 / CAPNS2 / Q96L46
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: 1
Band: q12.2
Gene start: 55566672
Gene end: 55567687
  
Corresponding Affymetrix probe sets: 223832_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000400882
NCBI entrez gene - 84290     See in Manteia.
OMIM - 616767
RefSeq - NM_032330
RefSeq Peptide - NP_115706
swissprot - Q96L46
Ensembl - ENSG00000256812
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 capns1aENSDARG00000035329Danio rerio
 capns1bENSDARG00000013804Danio rerio
 CAPNS2ENSGALG00000045050Gallus gallus
 Capns2ENSMUSG00000078144Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CAPNS1 / P04632 / calpain small subunit 1ENSG0000012624769
GCA / P28676 / grancalcinENSG0000011527125
SRI / P30626 / sorcinENSG0000007514225
PEF1 / Q9UBV8 / penta-EF-hand domain containing 1ENSG0000016251723
PDCD6 / O75340 / programmed cell death 6ENSG0000024991520


Protein motifs (from Interpro)
Interpro ID Name
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0022617 extracellular matrix disassembly TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0004198 calcium-dependent cysteine-type endopeptidase activity IDA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Degradation of the extracellular matrix
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimers disease models


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000014216 CAPN1 / P07384 / calpain 1  / complex
 ENSG00000153113 CAST / P20810 / calpastatin  / reaction / complex
 ENSG00000162909 CAPN2 / P17655 / calpain 2  / complex
 ENSG00000176749 CDK5R1 / Q15078 / cyclin dependent kinase 5 regulatory subunit 1  / reaction






 

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