ENSG00000075142


Homo sapiens

Features
Gene ID: ENSG00000075142
  
Biological name :SRI
  
Synonyms : P30626 / sorcin / SRI
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: q21.12
Gene start: 88205118
Gene end: 88226993
  
Corresponding Affymetrix probe sets: 208920_at (Human Genome U133 Plus 2.0 Array)   208921_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000415271
Ensembl peptide - ENSP00000378137
Ensembl peptide - ENSP00000418512
Ensembl peptide - ENSP00000391148
Ensembl peptide - ENSP00000397609
Ensembl peptide - ENSP00000265729
NCBI entrez gene - 6717     See in Manteia.
OMIM - 182520
RefSeq - XM_011516528
RefSeq - NM_001256891
RefSeq - NM_001256892
RefSeq - NM_003130
RefSeq - NM_198901
RefSeq Peptide - NP_001243820
RefSeq Peptide - NP_001243821
RefSeq Peptide - NP_003121
RefSeq Peptide - NP_944490
swissprot - C9J0K6
swissprot - E9PG82
swissprot - P30626
swissprot - B4DHQ6
Ensembl - ENSG00000075142
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sriENSDARG00000058593Danio rerio
 SRIENSGALG00000008985Gallus gallus
 SriENSMUSG00000003161Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GCA / P28676 / grancalcinENSG0000011527161
PEF1 / Q9UBV8 / penta-EF-hand domain containing 1ENSG0000016251740
CAPNS1 / P04632 / calpain small subunit 1ENSG0000012624735
PDCD6 / O75340 / programmed cell death 6ENSG0000024991533
CAPNS2 / Q96L46 / calpain small subunit 2ENSG0000025681231


Protein motifs (from Interpro)
Interpro ID Name
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR018247  EF-Hand 1, calcium-binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001508 action potential TAS
 biological_processGO:0006508 proteolysis IBA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0006880 intracellular sequestering of iron ion TAS
 biological_processGO:0006942 regulation of striated muscle contraction TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007507 heart development TAS
 biological_processGO:0007517 muscle organ development TAS
 biological_processGO:0008016 regulation of heart contraction TAS
 biological_processGO:0010459 negative regulation of heart rate IMP
 biological_processGO:0010649 regulation of cell communication by electrical coupling TAS
 biological_processGO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum TAS
 biological_processGO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus IEA
 biological_processGO:0042994 cytoplasmic sequestering of transcription factor IEA
 biological_processGO:0051281 positive regulation of release of sequestered calcium ion into cytosol IEA
 biological_processGO:0051924 regulation of calcium ion transport IMP
 biological_processGO:0055118 negative regulation of cardiac muscle contraction IEA
 biological_processGO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity IDA
 biological_processGO:0086004 regulation of cardiac muscle cell contraction IMP
 biological_processGO:1901077 regulation of relaxation of muscle IMP
 biological_processGO:1901841 regulation of high voltage-gated calcium channel activity IMP
 biological_processGO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction IMP
 biological_processGO:2000678 negative regulation of transcription regulatory region DNA binding IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IDA
 cellular_componentGO:0005790 smooth endoplasmic reticulum IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016529 sarcoplasmic reticulum TAS
 cellular_componentGO:0030018 Z disc IDA
 cellular_componentGO:0030315 T-tubule TAS
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0031982 vesicle IEA
 cellular_componentGO:0033017 sarcoplasmic reticulum membrane IEA
 cellular_componentGO:0042584 chromaffin granule membrane IDA
 cellular_componentGO:0043679 axon terminus IEA
 cellular_componentGO:0044326 dendritic spine neck IEA
 cellular_componentGO:0070062 extracellular exosome IDA
 molecular_functionGO:0002020 protease binding IPI
 molecular_functionGO:0004198 calcium-dependent cysteine-type endopeptidase activity IBA
 molecular_functionGO:0005102 signaling receptor binding TAS
 molecular_functionGO:0005246 calcium channel regulator activity TAS
 molecular_functionGO:0005509 calcium ion binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0044325 ion channel binding TAS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IPI
 molecular_functionGO:0070491 repressing transcription factor binding IEA


Pathways (from Reactome)
Pathway description
Stimuli-sensing channels
Reduction of cytosolic Ca++ levels
Sodium/Calcium exchangers
Ion homeostasis
Ion transport by P-type ATPases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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