ENSMUSG00000003161


Mus musculus

Features
Gene ID: ENSMUSG00000003161
  
Biological name :Sri
  
Synonyms : Q6P069 / Sorcin / Sri
  
Possible biological names infered from orthology : P30626
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: A1
Gene start: 8046078
Gene end: 8069379
  
Corresponding Affymetrix probe sets: 10519504 (MoGene1.0st)   1423155_at (Mouse Genome 430 2.0 Array)   1450878_at (Mouse Genome 430 2.0 Array)   1453457_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000086165
Ensembl peptide - ENSMUSP00000118221
NCBI entrez gene - 109552     See in Manteia.
MGI - MGI:98419
RefSeq - NM_001080974
RefSeq - NM_025618
RefSeq Peptide - NP_001074443
RefSeq Peptide - NP_079894
swissprot - Q6P069
Ensembl - ENSMUSG00000003161
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sriENSDARG00000058593Danio rerio
 SRIENSGALG00000008985Gallus gallus
 SRIENSG00000075142Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gca / Q8VC88 / Grancalcin / P28676*ENSMUSG0000002689362
Pef1 / Q8BFY6 / Peflin / Q9UBV8* / penta-EF-hand domain containing 1*ENSMUSG0000002877937
Capns1 / calpain small subunit 1 / P04632*ENSMUSG0000000179433
Pdcd6 / P12815 / Programmed cell death protein 6 / O75340* / programmed cell death 6*ENSMUSG0000002157632
Capns2 / Q9D7J7 / Calpain small subunit 2 / Q96L46*ENSMUSG0000007814431


Protein motifs (from Interpro)
Interpro ID Name
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR018247  EF-Hand 1, calcium-binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IBA
 biological_processGO:0006816 calcium ion transport IPI
 biological_processGO:0007507 heart development IEA
 biological_processGO:0010459 negative regulation of heart rate IEA
 biological_processGO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus IMP
 biological_processGO:0042994 cytoplasmic sequestering of transcription factor IMP
 biological_processGO:0051281 positive regulation of release of sequestered calcium ion into cytosol IMP
 biological_processGO:0051924 regulation of calcium ion transport IEA
 biological_processGO:0055118 negative regulation of cardiac muscle contraction IMP
 biological_processGO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity IEA
 biological_processGO:0086004 regulation of cardiac muscle cell contraction IEA
 biological_processGO:1901077 regulation of relaxation of muscle IEA
 biological_processGO:1901841 regulation of high voltage-gated calcium channel activity IEA
 biological_processGO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction IEA
 biological_processGO:2000678 negative regulation of transcription regulatory region DNA binding IMP
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005790 smooth endoplasmic reticulum IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane ISO
 cellular_componentGO:0016529 sarcoplasmic reticulum IEA
 cellular_componentGO:0030018 Z disc IEA
 cellular_componentGO:0030315 T-tubule IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0031982 vesicle IDA
 cellular_componentGO:0033017 sarcoplasmic reticulum membrane IEA
 cellular_componentGO:0042584 chromaffin granule membrane IEA
 cellular_componentGO:0043679 axon terminus IEA
 cellular_componentGO:0044326 dendritic spine neck IEA
 cellular_componentGO:0070062 extracellular exosome IEA
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0004198 calcium-dependent cysteine-type endopeptidase activity IBA
 molecular_functionGO:0005509 calcium ion binding ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0070491 repressing transcription factor binding IPI


Pathways (from Reactome)
Pathway description
Stimuli-sensing channels
Reduction of cytosolic Ca++ levels
Sodium/Calcium exchangers
Ion homeostasis
Ion transport by P-type ATPases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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