ENSMUSG00000026893


Mus musculus

Features
Gene ID: ENSMUSG00000026893
  
Biological name :Gca
  
Synonyms : Gca / Grancalcin / Q8VC88
  
Possible biological names infered from orthology : P28676
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: C1.3
Gene start: 62664285
Gene end: 62694109
  
Corresponding Affymetrix probe sets: 10472350 (MoGene1.0st)   1424698_s_at (Mouse Genome 430 2.0 Array)   1451451_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028257
NCBI entrez gene - 227960     See in Manteia.
MGI - MGI:1918521
RefSeq - NM_145523
RefSeq Peptide - NP_663498
swissprot - Q8VC88
Ensembl - ENSMUSG00000026893
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zgc:92027ENSDARG00000020187Danio rerio
 GCAENSG00000115271Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sri / Q6P069 / Sorcin / P30626*ENSMUSG0000000316156
Pef1 / Q8BFY6 / Peflin / Q9UBV8* / penta-EF-hand domain containing 1*ENSMUSG0000002877933
Capns1 / calpain small subunit 1 / P04632*ENSMUSG0000000179432
Capns2 / Q9D7J7 / Calpain small subunit 2 / Q96L46*ENSMUSG0000007814430
Pdcd6 / P12815 / Programmed cell death protein 6 / O75340* / programmed cell death 6*ENSMUSG0000002157629


Protein motifs (from Interpro)
Interpro ID Name
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR018247  EF-Hand 1, calcium-binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0004198 calcium-dependent cysteine-type endopeptidase activity IBA
 molecular_functionGO:0005509 calcium ion binding ISS
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0008734 decreased susceptibility to endotoxin shock "less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Rb1tm1Jyjw/Rb1tm1Jyjw
Genetic Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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