ENSMUSG00000021576


Mus musculus

Features
Gene ID: ENSMUSG00000021576
  
Biological name :Pdcd6
  
Synonyms : P12815 / Pdcd6 / Programmed cell death protein 6
  
Possible biological names infered from orthology : O75340 / programmed cell death 6
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: C1
Gene start: 74303509
Gene end: 74317580
  
Corresponding Affymetrix probe sets: 10410617 (MoGene1.0st)   1416027_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022060
Ensembl peptide - ENSMUSP00000152458
NCBI entrez gene - 18570     See in Manteia.
MGI - MGI:109283
RefSeq - XM_006517156
RefSeq - NM_011051
RefSeq Peptide - NP_035181
swissprot - P12815
Ensembl - ENSMUSG00000021576
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pdcd6ENSDARG00000005220Danio rerio
 PDCD6ENSGALG00000013400Gallus gallus
 PDCD6ENSG00000249915Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pef1 / Q8BFY6 / Peflin / Q9UBV8* / penta-EF-hand domain containing 1*ENSMUSG0000002877940
Sri / Q6P069 / Sorcin / P30626*ENSMUSG0000000316134
Gca / Q8VC88 / Grancalcin / P28676*ENSMUSG0000002689333
Capns2 / Q9D7J7 / Calpain small subunit 2 / Q96L46*ENSMUSG0000007814425
Capns1 / calpain small subunit 1 / P04632*ENSMUSG0000000179424


Protein motifs (from Interpro)
Interpro ID Name
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR018247  EF-Hand 1, calcium-binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001938 positive regulation of endothelial cell proliferation ISS
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006886 intracellular protein transport ISO
 biological_processGO:0006888 ER to Golgi vesicle-mediated transport ISS
 biological_processGO:0006915 apoptotic process IDA
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
 biological_processGO:0010595 positive regulation of endothelial cell migration ISS
 biological_processGO:0014029 neural crest formation ISO
 biological_processGO:0014032 neural crest cell development ISS
 biological_processGO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway ISS
 biological_processGO:0032007 negative regulation of TOR signaling ISO
 biological_processGO:0034605 cellular response to heat ISS
 biological_processGO:0036324 vascular endothelial growth factor receptor-2 signaling pathway ISO
 biological_processGO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
 biological_processGO:0045766 positive regulation of angiogenesis ISS
 biological_processGO:0048208 COPII vesicle coating ISO
 biological_processGO:0051592 response to calcium ion IDA
 biological_processGO:0051898 negative regulation of protein kinase B signaling ISS
 biological_processGO:1902527 positive regulation of protein monoubiquitination ISO
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0012507 ER to Golgi transport vesicle membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030127 COPII vesicle coat ISS
 cellular_componentGO:0031410 cytoplasmic vesicle ISO
 cellular_componentGO:0031463 Cul3-RING ubiquitin ligase complex ISO
 cellular_componentGO:0070971 endoplasmic reticulum exit site ISS
 molecular_functionGO:0000287 magnesium ion binding IDA
 molecular_functionGO:0004198 calcium-dependent cysteine-type endopeptidase activity IBA
 molecular_functionGO:0005509 calcium ion binding ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0043495 protein membrane anchor ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046983 protein dimerization activity ISO
 molecular_functionGO:0048306 calcium-dependent protein binding IPI
 molecular_functionGO:0060090 molecular adaptor activity ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gata1tm6Sho/Y
Genetic Background: involves: 129S1/Sv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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