ENSG00000249915


Homo sapiens

Features
Gene ID: ENSG00000249915
  
Biological name :PDCD6
  
Synonyms : O75340 / PDCD6 / programmed cell death 6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: p15.33
Gene start: 271621
Gene end: 353856
  
Corresponding Affymetrix probe sets: 1568763_s_at (Human Genome U133 Plus 2.0 Array)   203415_at (Human Genome U133 Plus 2.0 Array)   222152_at (Human Genome U133 Plus 2.0 Array)   222380_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000424201
Ensembl peptide - ENSP00000485941
Ensembl peptide - ENSP00000485024
Ensembl peptide - ENSP00000482332
Ensembl peptide - ENSP00000426003
Ensembl peptide - ENSP00000425370
Ensembl peptide - ENSP00000264933
Ensembl peptide - ENSP00000422085
Ensembl peptide - ENSP00000422691
Ensembl peptide - ENSP00000423815
NCBI entrez gene - 10016     See in Manteia.
OMIM - 601057
RefSeq - NM_013232
RefSeq - NM_001267556
RefSeq - NM_001267557
RefSeq - NM_001267558
RefSeq - NM_001267559
RefSeq Peptide - NP_001254485
RefSeq Peptide - NP_001254487
RefSeq Peptide - NP_001254488
RefSeq Peptide - NP_037364
RefSeq Peptide - NP_001254486
swissprot - Q86W51
swissprot - D6RA21
swissprot - A0A087WZ38
swissprot - A0A024QZ42
swissprot - H0Y9X3
swissprot - O75340
swissprot - E7EPW6
Ensembl - ENSG00000249915
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pdcd6ENSDARG00000005220Danio rerio
 PDCD6ENSGALG00000013400Gallus gallus
 Pdcd6ENSMUSG00000021576Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PEF1 / Q9UBV8 / penta-EF-hand domain containing 1ENSG0000016251743
SRI / P30626 / sorcinENSG0000007514234
GCA / P28676 / grancalcinENSG0000011527131
CAPNS2 / Q96L46 / calpain small subunit 2ENSG0000025681226
CAPNS1 / P04632 / calpain small subunit 1ENSG0000012624725


Protein motifs (from Interpro)
Interpro ID Name
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR018247  EF-Hand 1, calcium-binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IDA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006886 intracellular protein transport IDA
 biological_processGO:0006888 ER to Golgi vesicle-mediated transport IMP
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0010595 positive regulation of endothelial cell migration IDA
 biological_processGO:0014029 neural crest formation IMP
 biological_processGO:0014032 neural crest cell development IMP
 biological_processGO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway IDA
 biological_processGO:0032007 negative regulation of TOR signaling IDA
 biological_processGO:0034605 cellular response to heat IDA
 biological_processGO:0036324 vascular endothelial growth factor receptor-2 signaling pathway IDA
 biological_processGO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
 biological_processGO:0045766 positive regulation of angiogenesis IDA
 biological_processGO:0048208 COPII vesicle coating IMP
 biological_processGO:0051592 response to calcium ion ISS
 biological_processGO:0051898 negative regulation of protein kinase B signaling IDA
 biological_processGO:0097190 apoptotic signaling pathway TAS
 biological_processGO:1902527 positive regulation of protein monoubiquitination IMP
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0012507 ER to Golgi transport vesicle membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030127 COPII vesicle coat IDA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031463 Cul3-RING ubiquitin ligase complex IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0070971 endoplasmic reticulum exit site IMP
 molecular_functionGO:0000287 magnesium ion binding ISS
 molecular_functionGO:0004198 calcium-dependent cysteine-type endopeptidase activity IBA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0043495 protein membrane anchor IMP
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046983 protein dimerization activity IPI
 molecular_functionGO:0048306 calcium-dependent protein binding IPI
 molecular_functionGO:0060090 molecular adaptor activity IMP


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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