ENSG00000115271


Homo sapiens

Features
Gene ID: ENSG00000115271
  
Biological name :GCA
  
Synonyms : GCA / grancalcin / P28676
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q24.2
Gene start: 162318840
Gene end: 162371595
  
Corresponding Affymetrix probe sets: 203765_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000394842
Ensembl peptide - ENSP00000393218
Ensembl peptide - ENSP00000403805
Ensembl peptide - ENSP00000412899
Ensembl peptide - ENSP00000408620
Ensembl peptide - ENSP00000233612
NCBI entrez gene - 25801     See in Manteia.
OMIM - 607030
RefSeq - XM_017003769
RefSeq - XM_006712401
RefSeq - XM_011510926
RefSeq - XM_011510927
RefSeq - XM_011510928
RefSeq - XM_017003764
RefSeq - XM_017003765
RefSeq - XM_017003766
RefSeq - XM_017003767
RefSeq - XM_017003768
RefSeq - NM_012198
RefSeq - XM_005246446
RefSeq - XM_006712398
RefSeq - XM_006712400
RefSeq Peptide - NP_001317200
RefSeq Peptide - NP_036330
RefSeq Peptide - NP_001317199
swissprot - H7C2Z6
swissprot - C9JIZ3
swissprot - C9JWQ8
swissprot - P28676
swissprot - C9JV47
swissprot - H7BXD5
Ensembl - ENSG00000115271
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zgc:92027ENSDARG00000020187Danio rerio
 GcaENSMUSG00000026893Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SRI / P30626 / sorcinENSG0000007514256
PEF1 / Q9UBV8 / penta-EF-hand domain containing 1ENSG0000016251735
CAPNS1 / P04632 / calpain small subunit 1ENSG0000012624732
CAPNS2 / Q96L46 / calpain small subunit 2ENSG0000025681229
PDCD6 / O75340 / programmed cell death 6ENSG0000024991527


Protein motifs (from Interpro)
Interpro ID Name
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR018247  EF-Hand 1, calcium-binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IBA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0061025 membrane fusion TAS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0035578 azurophil granule lumen TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004198 calcium-dependent cysteine-type endopeptidase activity IBA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IPI


Pathways (from Reactome)
Pathway description
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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