ENSDARG00000034211


Danio rerio

Features
Gene ID: ENSDARG00000034211
  
Biological name :zgc:92480
  
Synonyms : zgc:92480
  
Possible biological names infered from orthology : calpain 2 / Calpain-2 catalytic subunit / CAPN2 / O08529 / P17655
  
Species: Danio rerio
  
Chr. number: 22
Strand: 1
Band:
Gene start: 26443235
Gene end: 26476078
  
Corresponding Affymetrix probe sets: Dr.10119.1.A1_at (Zebrafish Array)   Dr.1945.1.A1_at (Zebrafish Array)   Dr.1945.2.S1_at (Zebrafish Array)   NM_001003485_at (Zebrafish Genome Array with custom cdf files)   NM_001017807_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000044084
NCBI entrez gene - 550505     See in Manteia.
NCBI entrez gene - 445091     See in Manteia.
RefSeq - NM_001017807
RefSeq - NM_001003485
RefSeq Peptide - NP_001003485
RefSeq Peptide - NP_001017807
swissprot - Q6DFZ8
ZFIN ID - ZDB-GENE-040801-227
Ensembl - ENSDARG00000034211
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CAPN2ENSGALG00000009360Gallus gallus
 CAPN2ENSG00000162909Homo sapiens
 Capn2ENSMUSG00000026509Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
capn2a / calpain 2, (m/II) large subunit a / CAPN2* / P17655* / O08529* / calpain 2* / Calpain-2 catalytic subunit *ENSDARG0000009169969
capn2b / calpain 2, (m/II) large subunit b / CAPN2* / P17655* / O08529* / calpain 2* / Calpain-2 catalytic subunit *ENSDARG0000005559266
capn1b / calpain 1, (mu/I) large subunit b / CAPN11* / Q6J756* / Q9UMQ6* / calpain 11*ENSDARG0000005274864
capn1a / calpain 1, (mu/I) large subunit a / CAPN11* / Q6J756* / Q9UMQ6* / calpain 11*ENSDARG0000005270264
CAPN1 / si:dkeyp-50d11.2 / O35350* / P07384* / calpain 1* / Calpain-1 catalytic subunit *ENSDARG0000005533863
zgc:55262 / CAPN1* / O35350* / P07384* / calpain 1* / Calpain-1 catalytic subunit *ENSDARG0000004519963
capn8 / calpain 8 / A6NHC0*ENSDARG0000005571562
capn9 / calpain 9 / O14815* / Q9D805*ENSDARG0000001234152
capn3a / calpain 3a, (p94) / CAPN3* / P20807* / calpain 3*ENSDARG0000004186451
capn3b / calpain 3b / CAPN3* / P20807* / Q64691* / calpain 3*ENSDARG0000004303546
capn12 / calpain 12 / Q6ZSI9*ENSDARG0000001075838
zgc:136872 / A8MX76* / CAPN14* / CAPN13* / Q3UW68* / Q6MZZ7* / calpain 14* / calpain 13*ENSDARG0000000855336
si:ch211-202f3.3 / A8MX76* / CAPN14* / CAPN13* / Q3UW68* / Q6MZZ7* / calpain 14* / calpain 13*ENSDARG0000005291735
zgc:85932ENSDARG0000009823933
capn5b / calpain 5b / CAPN5* / O08688* / O15484* / calpain 5*ENSDARG0000006974831
capn5a / calpain 5a / CAPN5* / O08688* / O15484* / calpain 5*ENSDARG0000010331730
zgc:162184 / A8MX76* / CAPN14* / CAPN13* / Q3UW68* / Q6MZZ7* / calpain 14* / calpain 13*ENSDARG0000007721729
si:dkey-19b23.13ENSDARG0000006185029
si:ch211-202f3.4 / A8MX76* / CAPN14* / CAPN13* / Q3UW68* / Q6MZZ7* / calpain 14* / calpain 13*ENSDARG0000009172326


Protein motifs (from Interpro)
Interpro ID Name
 IPR000169  Cysteine peptidase, cysteine active site
 IPR001300  Peptidase C2, calpain, catalytic domain
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR018247  EF-Hand 1, calcium-binding site
 IPR022682  Peptidase C2, calpain, large subunit, domain III
 IPR022683  Peptidase C2, calpain, domain III
 IPR022684  Peptidase C2, calpain family
 IPR033883  Calpain subdomain III


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IBA
 biological_processGO:0051493 regulation of cytoskeleton organization IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0004198 calcium-dependent cysteine-type endopeptidase activity IBA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Degradation of the extracellular matrix


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000035329 capns1a / calpain, small subunit 1 a / Q9D7J7* / CAPNS1* / CAPNS2* / P04632* / Q96L46* / calpain small subunit 2* / calpain small subunit 1*  / complex
 ENSDARG00000013804 capns1b / calpain, small subunit 1 b / Q9D7J7* / CAPNS1* / CAPNS2* / P04632* / Q96L46* / calpain small subunit 2* / calpain small subunit 1*  / complex






 

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