ENSMUSG00000090071


Mus musculus

Features
Gene ID: ENSMUSG00000090071
  
Biological name :Cdk5r2
  
Synonyms : Cdk5r2 / Cyclin-dependent kinase 5 activator 2 / O35926
  
Possible biological names infered from orthology : cyclin dependent kinase 5 regulatory subunit 2 / Q13319
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: C4
Gene start: 74854934
Gene end: 74857732
  
Corresponding Affymetrix probe sets: 10347503 (MoGene1.0st)   1450465_at (Mouse Genome 430 2.0 Array)   1450466_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000125322
NCBI entrez gene - 12570     See in Manteia.
MGI - MGI:1330828
RefSeq - NM_009872
RefSeq Peptide - NP_034002
swissprot - O35926
Ensembl - ENSMUSG00000090071
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdk5r2aENSDARG00000071011Danio rerio
 cdk5r2bENSDARG00000078671Danio rerio
 CDK5R2ENSGALG00000025729Gallus gallus
 CDK5R2ENSG00000171450Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cdk5r1 / P61809 / Cyclin-dependent kinase 5 activator 1 Cyclin-dependent kinase 5 activator 1, p35 Cyclin-dependent kinase 5 activator 1, p25 / Q15078* / cyclin dependent kinase 5 regulator...ENSMUSG0000004889545


Protein motifs (from Interpro)
Interpro ID Name
 IPR004944  Cyclin-dependent kinase 5 activator
 IPR036915  Cyclin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001764 neuron migration IGI
 biological_processGO:0021549 cerebellum development IGI
 biological_processGO:0021722 superior olivary nucleus maturation IGI
 biological_processGO:0021766 hippocampus development IGI
 biological_processGO:0021819 layer formation in cerebral cortex IGI
 biological_processGO:0045860 positive regulation of protein kinase activity IGI
 biological_processGO:0045956 positive regulation of calcium ion-dependent exocytosis IDA
 biological_processGO:0071902 positive regulation of protein serine/threonine kinase activity IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016533 protein kinase 5 complex IEA
 molecular_functionGO:0008092 cytoskeletal protein binding TAS
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0016534 cyclin-dependent protein kinase 5 activator activity TAS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000746 weakness "state of being infirm or less strong than littermates" [J:45400]
Show

Allelic Composition: Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129S6/SvEvTac

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht,Cdk5r2tm1Lht/Cdk5r2tm1Lht
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000792 abnormal cortical marginal zone morphology 
Show

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht,Cdk5r2tm1Lht/Cdk5r2tm1Lht
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1+,Cdk5r2tm1Lht/Cdk5r2tm1Lht
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000812 abnormal dentate gyrus morphology "absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
Show

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht,Cdk5r2tm1Lht/Cdk5r2tm1Lht
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000813 abnormal hippocampal laminar structure "malformed or missing layers of the laminar structure of the hippocampus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
Show

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht,Cdk5r2tm1Lht/Cdk5r2tm1Lht
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1+,Cdk5r2tm1Lht/Cdk5r2tm1Lht
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht,Cdk5r2tm1Lht/Cdk5r2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1+,Cdk5r2tm1Lht/Cdk5r2tm1Lht
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht,Cdk5r2tm1Lht/Cdk5r2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000852 small cerebellum "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]
Show

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht,Cdk5r2tm1Lht/Cdk5r2tm1Lht
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1+,Cdk5r2tm1Lht/Cdk5r2tm1Lht
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht,Cdk5r2tm1Lht/Cdk5r2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000853 absent cerebellar foliation "missing small branches of the cerebellar lobules" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
Show

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht,Cdk5r2tm1Lht/Cdk5r2tm1Lht
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000854 abnormal cerebellum development "malformed or incomplete differentiation of the part of the metencephalon that lies dorsal to the pons and medulla behind the brain stem and controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129S6/SvEvTac

 MP:0000872 abnormal external granule cell layer "malformation of the transient layer of the cerebellar cortex which is composed of the dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht,Cdk5r2tm1Lht/Cdk5r2tm1Lht
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000937 abnormal motor neuron morphology "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of motor impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129S6/SvEvTac

 MP:0001491 unresponsive to tactile stimuli "absence of reflex action normally induced by touch or pain" [J:43515, J:47439]
Show

Allelic Composition: Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129S6/SvEvTac

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129S6/SvEvTac

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1+,Cdk5r2tm1Lht/Cdk5r2tm1Lht
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129S6/SvEvTac

 MP:0002739 abnormal olfactory bulb development "abnormality in the progression of the formation of the olfactory bulb" [J:65380, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht,Cdk5r2tm1Lht/Cdk5r2tm1Lht
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002883 chromatolysis "the dissolution of the granules of chromophil substance in a nerve cell body that may occur in injured cells or axons" [dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht,Cdk5r2tm1Lht/Cdk5r2tm1Lht
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008439 abnormal cortical plate morphology "any strucutral anomaly of the outer neural tube region in which post-mitotic neuroblasts migrate along radial glia to form the adult cortical layers" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:1812236]
Show

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht,Cdk5r2tm1Lht/Cdk5r2tm1Lht
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008441 thin cortical plate "reduced thickness of the outer neural tube region in which post-mitotic neuroblasts migrate along radial glia to form the adult cortical layers" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:1812236]
Show

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht,Cdk5r2tm1Lht/Cdk5r2tm1Lht
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1+,Cdk5r2tm1Lht/Cdk5r2tm1Lht
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009718 absent Purkinje cell layer "there is no evidence of the cell layer that lies just underneath the molecular layer of the cerebellar cortex, normally containing the neuronal cell bodies of the Purkinje cells arranged side by side in a single layer, and candelabrum interneurons vertically oriented between the Purkinje cells" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht,Cdk5r2tm1Lht/Cdk5r2tm1Lht
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht,Cdk5r2tm1Lht/Cdk5r2tm1Lht
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1+,Cdk5r2tm1Lht/Cdk5r2tm1Lht
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht,Cdk5r2tm1Lht/Cdk5r2tm1Lht
Genetic Background: involves: 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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