ENSG00000165672


Homo sapiens

Features
Gene ID: ENSG00000165672
  
Biological name :PRDX3
  
Synonyms : P30048 / peroxiredoxin 3 / PRDX3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: -1
Band: q26.11
Gene start: 119167703
Gene end: 119178833
  
Corresponding Affymetrix probe sets: 201619_at (Human Genome U133 Plus 2.0 Array)   209766_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000298510
NCBI entrez gene - 10935     See in Manteia.
OMIM - 604769
RefSeq - NM_006793
RefSeq - NM_001302272
RefSeq Peptide - NP_001289201
RefSeq Peptide - NP_006784
swissprot - P30048
Ensembl - ENSG00000165672
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prdx3ENSDARG00000032102Danio rerio
 PRDX3ENSGALG00000009369Gallus gallus
 Prdx3ENSMUSG00000024997Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PRDX4 / Q13162 / peroxiredoxin 4ENSG0000012313154
PRDX2 / P32119 / peroxiredoxin 2ENSG0000016781550
PRDX1 / Q06830 / peroxiredoxin 1ENSG0000011745049


Protein motifs (from Interpro)
Interpro ID Name
 IPR000866  Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant
 IPR013766  Thioredoxin domain
 IPR019479  Peroxiredoxin, C-terminal
 IPR024706  Peroxiredoxin, AhpC-type
 IPR036249  Thioredoxin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001893 maternal placenta development IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0007005 mitochondrion organization IMP
 biological_processGO:0008284 positive regulation of cell proliferation IDA
 biological_processGO:0018171 peptidyl-cysteine oxidation IDA
 biological_processGO:0030099 myeloid cell differentiation IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0033673 negative regulation of kinase activity IDA
 biological_processGO:0034599 cellular response to oxidative stress IDA
 biological_processGO:0034614 cellular response to reactive oxygen species IMP
 biological_processGO:0042542 response to hydrogen peroxide IDA
 biological_processGO:0042744 hydrogen peroxide catabolic process IDA
 biological_processGO:0043066 negative regulation of apoptotic process IDA
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0045454 cell redox homeostasis IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IDA
 biological_processGO:0051881 regulation of mitochondrial membrane potential IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0098869 cellular oxidant detoxification IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005759 mitochondrial matrix TAS
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0008385 IkappaB kinase complex IPI
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0043209 myelin sheath IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004601 peroxidase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding IPI
 molecular_functionGO:0008379 thioredoxin peroxidase activity IDA
 molecular_functionGO:0008785 alkyl hydroperoxide reductase activity NAS
 molecular_functionGO:0016209 antioxidant activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0019900 kinase binding IPI
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process IMP
 molecular_functionGO:0051920 peroxiredoxin activity IEA


Pathways (from Reactome)
Pathway description
Detoxification of Reactive Oxygen Species


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000165672 PRDX3 / P30048 / peroxiredoxin 3  / complex
 ENSG00000100348 TXN2 / Q99757 / thioredoxin 2  / reaction






 

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