ENSG00000265972


Homo sapiens

Features
Gene ID: ENSG00000265972
  
Biological name :TXNIP
  
Synonyms : Q9H3M7 / thioredoxin interacting protein / TXNIP
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q21.1
Gene start: 145992435
Gene end: 145996600
  
Corresponding Affymetrix probe sets: 201008_s_at (Human Genome U133 Plus 2.0 Array)   201009_s_at (Human Genome U133 Plus 2.0 Array)   201010_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000462521
Ensembl peptide - ENSP00000396322
NCBI entrez gene - 10628     See in Manteia.
OMIM - 606599
RefSeq - XM_017000085
RefSeq - NM_001313972
RefSeq - NM_006472
RefSeq Peptide - NP_001300901
RefSeq Peptide - NP_006463
swissprot - Q9H3M7
swissprot - A0A024R4B7
Ensembl - ENSG00000265972
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 txnipaENSDARG00000036107Danio rerio
 txnipbENSDARG00000070000Danio rerio
 TxnipENSMUSG00000038393Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ARRDC4 / Q8NCT1 / arrestin domain containing 4ENSG0000014045044
ARRDC3 / Q96B67 / arrestin domain containing 3ENSG0000011336942
ARRDC2 / Q8TBH0 / arrestin domain containing 2ENSG0000010564338
ARRDC1 / Q8N5I2 / arrestin domain containing 1ENSG0000019707021


Protein motifs (from Interpro)
Interpro ID Name
 IPR011021  Arrestin-like, N-terminal
 IPR011022  Arrestin C-terminal-like domain
 IPR014756  Immunoglobulin E-set


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006606 protein import into nucleus IEA
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0009749 response to glucose IEA
 biological_processGO:0030216 keratinocyte differentiation IDA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0032570 response to progesterone IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042542 response to hydrogen peroxide IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043086 negative regulation of catalytic activity IEA
 biological_processGO:0048008 platelet-derived growth factor receptor signaling pathway IEA
 biological_processGO:0051592 response to calcium ion IEA
 biological_processGO:0051782 negative regulation of cell division IDA
 biological_processGO:0071228 cellular response to tumor cell IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005758 mitochondrial intermembrane space IEA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0004857 enzyme inhibitor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI


Pathways (from Reactome)
Pathway description
The NLRP3 inflammasome


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000162711 NLRP3 / Q96P20 / NLR family pyrin domain containing 3  / reaction / complex
 ENSG00000136810 TXN / P10599 / thioredoxin  / complex / reaction






 

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