ENSMUSG00000075704


Mus musculus

Features
Gene ID: ENSMUSG00000075704
  
Biological name :Txnrd2
  
Synonyms : thioredoxin reductase 2 / Txnrd2
  
Possible biological names infered from orthology : Q9NNW7
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: A3
Gene start: 18426384
Gene end: 18479073
  
Corresponding Affymetrix probe sets: 10434191 (MoGene1.0st)   1429971_at (Mouse Genome 430 2.0 Array)   1429972_s_at (Mouse Genome 430 2.0 Array)   1449097_at (Mouse Genome 430 2.0 Array)   1451936_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000136373
Ensembl peptide - ENSMUSP00000146311
Ensembl peptide - ENSMUSP00000146174
Ensembl peptide - ENSMUSP00000146143
Ensembl peptide - ENSMUSP00000146096
Ensembl peptide - ENSMUSP00000146030
Ensembl peptide - ENSMUSP00000145926
Ensembl peptide - ENSMUSP00000145730
Ensembl peptide - ENSMUSP00000136402
Ensembl peptide - ENSMUSP00000111267
Ensembl peptide - ENSMUSP00000111268
Ensembl peptide - ENSMUSP00000111269
NCBI entrez gene - 26462     See in Manteia.
MGI - MGI:1347023
RefSeq - NM_001353143
RefSeq - NM_013711
RefSeq Peptide - NP_001340072
RefSeq Peptide - NP_038739
swissprot - A0A0U1RPC6
swissprot - A0A0M3HEQ0
swissprot - A0A0M3HEP9
swissprot - J3QMN4
swissprot - J3QMQ8
swissprot - D3Z0K8
swissprot - Q9D8I4
swissprot - A0A0U1RQA4
swissprot - A0A0U1RPY5
swissprot - A0A0U1RPV8
swissprot - A0A0U1RPS1
Ensembl - ENSMUSG00000075704
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 txnrd2.1ENSDARG00000094470Danio rerio
 txnrd2.2ENSDARG00000075923Danio rerio
 TXNRD2ENSGALG00000001988Gallus gallus
 Q9NNW7ENSG00000184470Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Txnrd3 / thioredoxin reductase 3 / Q86VQ6*ENSMUSG0000000081153
Q9JMH6 / Txnrd1 / thioredoxin reductase 1 / Q16881*ENSMUSG0000002025052
Gsr / P47791 / Glutathione reductase, mitochondrial / P00390* / glutathione-disulfide reductase*ENSMUSG0000003158435


Protein motifs (from Interpro)
Interpro ID Name
 IPR001100  Pyridine nucleotide-disulphide oxidoreductase, class I
 IPR004099  Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
 IPR006338  Thioredoxin/glutathione reductase selenoprotein
 IPR012999  Pyridine nucleotide-disulphide oxidoreductase, class I, active site
 IPR016156  FAD/NAD-linked reductase, dimerisation domain superfamily
 IPR023753  FAD/NAD(P)-binding domain
 IPR036188  FAD/NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0022900 electron transport chain IEA
 biological_processGO:0045454 cell redox homeostasis IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0098869 cellular oxidant detoxification IEA
 cellular_componentGO:0005623 cell IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0004791 thioredoxin-disulfide reductase activity IEA
 molecular_functionGO:0009055 electron transfer activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor IEA
 molecular_functionGO:0050660 flavin adenine dinucleotide binding IEA


Pathways (from Reactome)
Pathway description
Detoxification of Reactive Oxygen Species


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000233 abnormal blood flow velocity "anomalous rate of flow of the blood through vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Txnrd2tm1Marc/Txnrd2tm1.1Marc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Txnrd2tm1Marc/Txnrd2tm1.1Marc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000277 abnormal heart shape "malformation of the form or the patterning of the heart" [J:18048]
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Allelic Composition: Acvr1ctm1Cfi/Acvr1ctm1Cfi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Txnrd2tm1Marc/Txnrd2tm1.1Marc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Txnrd2tm1Marc/Txnrd2tm1.1Marc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Txnrd2tm1.1Marc/Txnrd2tm1.1Marc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000295 poorly developed ventricular trabeculae "retarded differentation of the supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [J:29971]
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Allelic Composition: Txnrd2tm1.1Marc/Txnrd2tm1.1Marc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Txnrd2tm1Marc/Txnrd2tm1.1Marc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Txnrd2tm1Marc/Txnrd2tm1.1Marc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Acvr1ctm1Cfi/Acvr1ctm1Cfi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Txnrd2tm1Marc/Txnrd2tm1.1Marc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdh23v/Cdh23v
Genetic Background: involves: fanciers stocks

 MP:0003140 dilated atria "an expansion in the volume of one or both of the upper chambers of the heart" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Txnrd2tm1Marc/Txnrd2tm1.1Marc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Txnrd2tm1Marc/Txnrd2tm1.1Marc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010019 liver vascular congestion "obstruction of the normal flux of blood within the blood vessel network of the liver" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Txnrd2tm1Marc/Txnrd2tm1.1Marc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010725 thin interventricular septum "decreased thickness of the wall between the two lower chambers of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Txnrd2tm1.1Marc/Txnrd2tm1.1Marc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Txnrd2tm1Marc/Txnrd2tm1.1Marc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Txnrd2tm1.1Marc/Txnrd2tm1.1Marc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011395 decreased fetal cardiomyocyte proliferation "reduced ability of the differentiating cardiac muscle cell population to undergo expansion by cell division" [MGI:csmith]
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Allelic Composition: Txnrd2tm1.1Marc/Txnrd2tm1.1Marc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
Show

Allelic Composition: Txnrd2tm1.1Marc/Txnrd2tm1.1Marc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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