ENSMUSG00000075705


Mus musculus

Features
Gene ID: ENSMUSG00000075705
  
Biological name :Msrb1
  
Synonyms : Msrb1 / Mus musculus methionine sulfoxide reductase B1 (Msrb1), transcript variant 2, mRNA. / Q9JLC3
  
Possible biological names infered from orthology : methionine sulfoxide reductase B1 / Q9NZV6
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: A3.3
Gene start: 24736642
Gene end: 24742778
  
Corresponding Affymetrix probe sets: 10442596 (MoGene1.0st)   1418888_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099300
Ensembl peptide - ENSMUSP00000110917
NCBI entrez gene - 27361     See in Manteia.
MGI - MGI:1351642
RefSeq - NM_001346668
RefSeq - NM_013759
RefSeq Peptide - NP_001333597
RefSeq Peptide - NP_038787
swissprot - Q9JLC3
Ensembl - ENSMUSG00000075705
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 msrb1aENSDARG00000025436Danio rerio
 msrb1bENSDARG00000045160Danio rerio
 MSRB1ENSGALG00000005414Gallus gallus
 MSRB1ENSG00000198736Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002579  Peptide methionine sulphoxide reductase MrsB
 IPR011057  Mss4-like superfamily
 IPR028427  Peptide methionine sulfoxide reductase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0030041 actin filament polymerization IDA
 biological_processGO:0030091 protein repair IDA
 biological_processGO:0045087 innate immune response IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0015629 actin cytoskeleton IDA
 molecular_functionGO:0003779 actin binding IDA
 molecular_functionGO:0008270 zinc ion binding IDA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor IEA
 molecular_functionGO:0033743 peptide-methionine (R)-S-oxide reductase activity IDA
 molecular_functionGO:0033745 L-methionine-(R)-S-oxide reductase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070191 methionine-R-sulfoxide reductase activity IDA


Pathways (from Reactome)
Pathway description
Protein repair


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Rhotm4.1(RHO*/EGFP)Jhw/Rho+
Genetic Background: B6.129S7-Rhotm4.1(RHO*/EGFP)Jhw

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rhotm4.1(RHO*/EGFP)Jhw/Rho+
Genetic Background: B6.129S7-Rhotm4.1(RHO*/EGFP)Jhw

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rb1tm1Tyj/Rb1tm2Tyj
Genetic Background: chimera involves: 129S2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028367 Txn1 / P10639 / thioredoxin 1 / TXN* / P10599* / thioredoxin*  / reaction






 

1 s.

 
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