ENSMUSG00000015721


Mus musculus

Features
Gene ID: ENSMUSG00000015721
  
Biological name :Nlrp5
  
Synonyms : NACHT, LRR and PYD domains-containing protein 5 / Nlrp5 / Q9R1M5
  
Possible biological names infered from orthology : NLR family pyrin domain containing 5 / P59047
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: A3
Gene start: 23385889
Gene end: 23441922
  
Corresponding Affymetrix probe sets: 10550795 (MoGene1.0st)   1418882_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000104080
Ensembl peptide - ENSMUSP00000015866
Ensembl peptide - ENSMUSP00000083524
Ensembl peptide - ENSMUSP00000118638
Ensembl peptide - ENSMUSP00000122007
NCBI entrez gene - 23968     See in Manteia.
MGI - MGI:1345193
RefSeq - NM_001039143
RefSeq - NM_001305857
RefSeq - NM_011860
RefSeq Peptide - NP_001034232
RefSeq Peptide - NP_001292786
RefSeq Peptide - NP_035990
swissprot - Q9R1M5
Ensembl - ENSMUSG00000015721
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FO704635.1ENSDARG00000105141Danio rerio
 nlrb5ENSDARG00000090699Danio rerio
 si:ch211-66k16.2ENSDARG00000095634Danio rerio
 si:ch211-66k16.28ENSDARG00000088423Danio rerio
 NLRP5ENSG00000171487Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nlrp14 / Q6B966 / NACHT, LRR and PYD domains-containing protein 14 / Q86W24* / NLR family pyrin domain containing 14*ENSMUSG0000001662629
Nlrp3 / Q8R4B8 / NACHT, LRR and PYD domains-containing protein 3 / Q96P20* / NLR family pyrin domain containing 3*ENSMUSG0000003269125
Nlrp4c / Q3TKR3 / NACHT, LRR and PYD domains-containing protein 4C / NLRP4* / Q96MN2* / NLR family pyrin domain containing 4*ENSMUSG0000003469024
Nlrp9b / Q66X22 / NACHT, LRR and PYD domains-containing protein 9B / NLRP9* / Q7RTR0* / NLR family pyrin domain containing 9*ENSMUSG0000006050824
E9Q5R7 / Nlrp12 / NACHT, LRR and PYD domains-containing protein 12 / P59046* / NLR family pyrin domain containing 12*ENSMUSG0000007881724
Nlrp4e / Q66X19 / NACHT, LRR and PYD domains-containing protein 4E / NLRP4* / Q96MN2* / NLR family pyrin domain containing 4*ENSMUSG0000004569323
Nlrp9a / NACHT, LRR and PYD domains-containing protein 9A isoform 3 / NLRP9* / Q7RTR0* / NLR family pyrin domain containing 9*ENSMUSG0000005410223
Nlrp4a / Q8BU40 / NACHT, LRR and PYD domains-containing protein 4A / NLRP4* / Q96MN2* / NLR family pyrin domain containing 4*ENSMUSG0000004060123
Nlrp9c / Q66X01 / NACHT, LRR and PYD domains-containing protein 9C / NLRP9* / Q7RTR0* / NLR family pyrin domain containing 9*ENSMUSG0000004061423
Nlrp4f / NLRP4* / Q96MN2* / NLR family pyrin domain containing 4*ENSMUSG0000003299922
Nlrp2 / NLRP7* / Q8WX94* / Q9NX02* / NLR family pyrin domain containing 7* / NLR family pyrin domain containing 2*ENSMUSG0000003517722
Nlrp1a / Q2LKU9 / NACHT, LRR and PYD domains-containing protein 1a / NLRP1* / Q9C000* / NLR family pyrin domain containing 1*ENSMUSG0000006983021
A1Z198 / Nlrp1b / NACHT, LRR and PYD domains-containing protein 1b allele 2 / NLRP1* / Q9C000* / NLR family pyrin domain containing 1*ENSMUSG0000007039019
Nlrp4b / Q8C6J9 / Mus musculus NLR family, pyrin domain containing 4B (Nlrp4b), transcript variant 2, mRNA. / NLRP4* / Q96MN2* / NLR family pyrin domain containing 4*ENSMUSG0000003408719
Nlrp6 / Q91WS2 / NACHT, LRR and PYD domains-containing protein 6 / P59044* / NLR family pyrin domain containing 6*ENSMUSG0000003874518
Nlrp10 / Q8CCN1 / NACHT, LRR and PYD domains-containing protein 10 / Q86W26* / NLR family pyrin domain containing 10*ENSMUSG0000004970911
Rnh1 / Q91VI7 / Ribonuclease inhibitor / P13489* / ribonuclease/angiogenin inhibitor 1*ENSMUSG0000003865011


Protein motifs (from Interpro)
Interpro ID Name
 IPR001611  Leucine-rich repeat
 IPR007111  NACHT nucleoside triphosphatase
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0007566 embryo implantation IMP
 biological_processGO:0009566 fertilization IMP
 biological_processGO:0009887 animal organ morphogenesis IMP
 biological_processGO:0031647 regulation of protein stability IMP
 biological_processGO:0034613 cellular protein localization IMP
 biological_processGO:0043487 regulation of RNA stability IMP
 biological_processGO:0070997 neuron death ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005938 cell cortex IDA
 cellular_componentGO:0045179 apical cortex IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Sirt1tm1.1Cxd/Sirt1+,Trp53tm1Brd/Trp53+
Genetic Background: either: (involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB/N) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB/N)

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Lipetm1Gam/Lipetm1Gam
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Nlrp5tm1Zbt/Nlrp5tm1Zbt,OoepGt(139A2)Cmhd/OoepGt(139A2)Cmhd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003718 maternal effect "expression of a phenotypic trait in an female animal s offspring that is dependent on the maternal genotype" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lipetm1Gam/Lipetm1Gam
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Nlrp5tm1Zbt/Nlrp5tm1Zbt,OoepGt(139A2)Cmhd/OoepGt(139A2)Cmhd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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