ENSMUSG00000032308


Mus musculus

Features
Gene ID: ENSMUSG00000032308
  
Biological name :Ulk3
  
Synonyms : Q3U3Q1 / Ulk3 / unc-51-like kinase 3
  
Possible biological names infered from orthology : Q6PHR2
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: B
Gene start: 57589452
Gene end: 57596233
  
Corresponding Affymetrix probe sets: 10585732 (MoGene1.0st)   1431112_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000149623
Ensembl peptide - ENSMUSP00000059947
NCBI entrez gene - 71742     See in Manteia.
MGI - MGI:1918992
RefSeq - NM_027895
RefSeq Peptide - NP_082171
swissprot - A0A1L1SRU5
swissprot - Q3U3Q1
Ensembl - ENSMUSG00000032308
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ulk3ENSDARG00000101661Danio rerio
 ULK3ENSGALG00000032215Gallus gallus
 ULK3ENSG00000140474Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ulk1 / unc-51 like kinase 1 / O75385* / unc-51 like autophagy activating kinase 1*ENSMUSG0000002951234
Ulk2 / Q9QY01 / unc-51 like kinase 2 / Q8IYT8* / unc-51 like autophagy activating kinase 2*ENSMUSG0000000479832
Ikbke / Q9R0T8 / Inhibitor of nuclear factor kappa-B kinase subunit epsilon / Q14164*ENSMUSG0000004234921
Tbk1 / Q9WUN2 / TANK-binding kinase 1 / Q9UHD2*ENSMUSG0000002011519
Ikbkb / inhibitor of kappaB kinase beta / O14920* / inhibitor of nuclear factor kappa B kinase subunit beta*ENSMUSG0000003153719
Chuk / conserved helix-loop-helix ubiquitous kinase / O15111*ENSMUSG0000002519918


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR007330  MIT
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR036181  MIT domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0045879 negative regulation of smoothened signaling pathway IEA
 biological_processGO:0045880 positive regulation of smoothened signaling pathway IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 cellular_componentGO:0005737 cytoplasm ISS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity ISO
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Hedgehog on state


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025407 Gli1 / P47806 / Zinc finger protein GLI1 / P08151* / GLI family zinc finger 1*  / reaction
 ENSMUSG00000048402 Gli2 / Q0VGT2 / Zinc finger protein GLI2 / P10070* / GLI family zinc finger 2*  / reaction
 ENSMUSG00000021318 Gli3 / Q61602 / Transcriptional activator GLI3 Transcriptional repressor GLI3R / P10071* / GLI family zinc finger 3*  / reaction
 ENSMUSG00000025231 Sufu / Q9Z0P7 / SUFU negative regulator of hedgehog signaling / Q9UMX1*  / complex






 

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