ENSG00000140474


Homo sapiens

Features
Gene ID: ENSG00000140474
  
Biological name :ULK3
  
Synonyms : Q6PHR2 / ULK3 / unc-51 like kinase 3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: -1
Band: q24.1
Gene start: 74836116
Gene end: 74843346
  
Corresponding Affymetrix probe sets: 225067_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000486917
Ensembl peptide - ENSP00000457853
Ensembl peptide - ENSP00000457983
Ensembl peptide - ENSP00000400312
Ensembl peptide - ENSP00000454583
Ensembl peptide - ENSP00000455199
Ensembl peptide - ENSP00000455395
Ensembl peptide - ENSP00000456051
Ensembl peptide - ENSP00000456296
Ensembl peptide - ENSP00000456510
Ensembl peptide - ENSP00000457061
Ensembl peptide - ENSP00000457305
NCBI entrez gene - 25989     See in Manteia.
OMIM - 613472
RefSeq - XM_017022072
RefSeq - NM_001099436
RefSeq - NM_001284364
RefSeq - NM_001284365
RefSeq - XM_005254289
RefSeq - XM_017022068
RefSeq - XM_017022069
RefSeq - XM_017022070
RefSeq - XM_017022071
RefSeq Peptide - NP_001271293
RefSeq Peptide - NP_001271294
RefSeq Peptide - NP_001092906
swissprot - H3BS27
swissprot - H3BT78
swissprot - H3BTS3
swissprot - H3BV76
swissprot - H3BMW8
swissprot - Q6PHR2
swissprot - H3BP85
swissprot - H3BPN6
Ensembl - ENSG00000140474
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ulk3ENSDARG00000101661Danio rerio
 ULK3ENSGALG00000032215Gallus gallus
 Ulk3ENSMUSG00000032308Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ULK1 / O75385 / unc-51 like autophagy activating kinase 1ENSG0000017716935
ULK2 / Q8IYT8 / unc-51 like autophagy activating kinase 2ENSG0000008329032
IKBKE / Q14164 / inhibitor of nuclear factor kappa B kinase subunit epsilonENSG0000026352820
IKBKB / O14920 / inhibitor of nuclear factor kappa B kinase subunit betaENSG0000010436520
TBK1 / Q9UHD2 / TANK binding kinase 1ENSG0000018373519
CHUK / O15111 / conserved helix-loop-helix ubiquitous kinaseENSG0000021334118


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR007330  MIT
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR036181  MIT domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006914 autophagy TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0045879 negative regulation of smoothened signaling pathway IDA
 biological_processGO:0045880 positive regulation of smoothened signaling pathway IDA
 biological_processGO:0046777 protein autophosphorylation IDA
 biological_processGO:0090398 cellular senescence TAS
 cellular_componentGO:0000407 phagophore assembly site TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0097542 ciliary tip TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Hedgehog on state


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000107882 SUFU / Q9UMX1 / SUFU negative regulator of hedgehog signaling  / complex
 ENSG00000074047 GLI2 / P10070 / GLI family zinc finger 2  / reaction
 ENSG00000111087 GLI1 / P08151 / GLI family zinc finger 1  / reaction
 ENSG00000106571 GLI3 / P10071 / GLI family zinc finger 3  / reaction






 

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